1. Protein Tyrosine Kinase/RTK
  2. Insulin Receptor

NT157 (Synonyms: Tyrphostin NT157)

Cat. No.: HY-100037 Purity: 99.19%
Data Sheet SDS Handling Instructions

NT157is a selective inhibitor of IRS-1/2, IC50 values at sub-micromolar doses (ranging from 0.3 to 0.8 μM) .

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NT157 Chemical Structure

NT157 Chemical Structure

CAS No. : 1384426-12-3

Size Price Stock Quantity
10 mM * 1 mL in DMSO $190 In-stock
2 mg $110 In-stock
5 mg $210 In-stock
10 mg $310 In-stock
25 mg $600 In-stock
50 mg $950 In-stock
100 mg   Get quote  
200 mg   Get quote  

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  • Biological Activity

  • Protocol

  • Technical Information

  • Purity & Documentation

  • References

Description

NT157is a selective inhibitor of IRS-1/2, IC50 values at sub-micromolar doses (ranging from 0.3 to 0.8 μM) . IC50 value: 0.3 to 0.8 μM [1] Target: Insulin receptor in vitro: NT157 significantly affects the cells' migratory ability, as confirmed by a wound-healing assay. NT157 induces cytostatic effects, as evidenced by G2/M cell cycle arrest, and does not affect apoptosis. NT157, a novel small-molecule that specifically targets IRS protein, in OS cells. NT157 is a small-molecule inhibitor that induces Ser-phosphorylation and consequently the degradation of IRS-1 and IRS-2. NT157 efficiently affects migration ability of MG-63 and U-2OS OS cells. NT157 treatment induces cell cycle arrest and inhibits IGF system signaling. [1] The density of LNCaP cells grown in FBS was decreased approximately 20% at 1 μM, approximately 70% at 2 μM, and >90% at 5 μM (IC50, 1.4 μM). Growth of LNCaP cells is suppressed >60% when cultured in CSS but still exhibited significant density at 2 μM and maximal decreased density at 5 μM. The density of FBS-cultured PC3 cells was similarly decreased by NT157 treatment (40% at 2 μM and > 70% at 5 μM; IC50, 2.5 μM). [2] in vivo: NT157 suppresses growth of LNCaP xenografts following castration. NT157 treatment affects IGF1R and IRS targets in xenografts and significantly delays castration-resistant progression of LNCaP androgen-responsive xenografts when combined with castration. NT157 potentiates docetaxel activity in PC3 xenografts.[2]

References
Preparing Stock Solutions
Concentration Volume Mass 1 mg 5 mg 10 mg
1 mM 2.4257 mL 12.1283 mL 24.2565 mL
5 mM 0.4851 mL 2.4257 mL 4.8513 mL
10 mM 0.2426 mL 1.2128 mL 2.4257 mL
Please refer to the solubility information to select the appropriate solvent.
References
Molecular Weight

412.26

Formula

C₁₆H₁₄BrNO₅S

CAS No.

1384426-12-3

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Shipping

Room temperature in continental US; may vary elsewhere

Solvent & Solubility

DMSO: ≥ 30 mg/mL

* "<1 mg/mL" means slightly soluble or insoluble. "≥" means soluble, but saturation unknown.

Purity: 99.19%

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Product Name:
NT157
Cat. No.:
HY-100037
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