1. Natural Products
  2. Plants
  3. Leguminosae
  4. Caesalpinia sappan L.

Caesalpinia sappan L.

Caesalpinia sappan L. (17):

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-113556
    Sappanone A 102067-84-5 98.42%
    Sappanone A is a homoisoflavanone which exhibits anti-inflammatory effects via modulation of Nrf2 and NF-κB. Sappanone can attenuate allergic airway inflammation in Ovalbumin-induced asthma.
    Sappanone A
  • HY-N0116
    Hematoxylin 517-28-2 98.02%
    Hematoxylin (Natural Black 1), a naturally occurring flavonoid compound derived from Caesalpinia sappan Linn.. Hematoxylin is a nuclear stain in histology and is also a potent Aβ42 fibrillogenesis inhibitor with an IC50 of 1.6 μM.
  • HY-N0072
    Brazilin 474-07-7 99.26%
    Brazilin is a red dye precursor obtained from the heartwood of several species of tropical hardwoods. Brazilin inhibits the cells proliferation, promotes apoptosis, and induces autophagy through the AMPK/mTOR pathway. Brazilin shows chondroprotective and anti-inflammatory activities.
  • HY-113573
    Protosappanin A 102036-28-2 99.98%
    Protosappanin A (PTA), an immunosuppressive ingredient and major biphenyl compound isolated from Caesalpinia sappan L, suppresses JAK2/STAT3-dependent inflammation pathway through down-regulating the phosphorylation of JAK2 and STAT3.
    Protosappanin A
  • HY-N0800
    Protosappanin B 102036-29-3 99.46%
    Protosappanin B is a phenolic compound extracted from Caesalpinia sappan. Anti-cancer activity. Protosappanin B induces apoptosis and causes G1 cell cycle arrest in human bladder cancer cells.
    Protosappanin B
  • HY-N10108
    Protosappanin A dimethyl acetal 868405-37-2
    Protosappanin A dimethyl acetal is a homoisoflavonoid. Protosappanin A dimethyl acetal can be isolated from Caesalpinia sappan. Protosappanin A dimethyl acetal is also a competive inhibitor with significant xanthine oxidase inhibitory activity (IC50=50.7 μM).
    Protosappanin A dimethyl acetal
  • HY-N10069
    Bonducellin 83162-84-9
    Bonducellin is a a homoisoflavonoid, which can be isolated from Caesalpinia digyna roots. Bonducellin is a potent inhibitor of efflux pump (EP), while EP induces resistance in mycobacteria and serves as a target of anti-TB (tuberculosis) agents. Bonducellin reduces MIC of EtBr by 8-fold against M. smegmatis (MIC=62.5 mg/L).
  • HY-N1745A
    3-Deoxysappanchalcone 112408-67-0 99.26%
    3-Deoxysappanchalcone is a naturally-occurring chalcone compound isolated from Caesalpinia sappan L.
  • HY-N9315
    Episappanol 111254-18-3 98.57%
    Episappanol is a natural compound isolated from Caesalpinia sappan heartwood with anti-inflammatory activity. Episappanol significantly inhibits the IL-6 and TNF-α secretion.
  • HY-59001
    Sappanchalcone 94344-54-4 99.62%
    Sappanchalcone, a flavonoid isolated from Caesalpinia sappan L., induces caspase-dependent and AIF-dependent apoptosis in human colon cancer cells.
  • HY-N10424
    Brazilein 600-76-0
    Brazilein is an important immunosuppressive component isolated from Caesalpinia sappan L. Brazilein induces apoptosis in mice spleen lymphocytes.
  • HY-N1818
    Deoxysappanone B 113122-54-6
    Deoxysappanone B (3-Deoxysappanone B) is a homoisoflavone compound isolated from Caesalpinia sappan L (Lignum Sappan). Deoxysappanone B has anti-neuroinflammatory and neuroprotective effects and inhibits the production of neuroinflammatory mediators by blocking the IκB kinase (IKK)-NF-κB and p38/ERK MAPK pathways. Deoxysappanone B can be used in disease studies of neuritis and inflammation-related neurological damage.
    Deoxysappanone B
  • HY-N2735
    7,3',4'-Trihydroxy-3-benzyl-2H-chromene 1111897-60-9
    7,3',4'-Trihydroxy-3-benzyl-2H-chromene is an reversible noncompetitive neuraminidase (NA) inhibitor. 7,3',4'-Trihydroxy-3-benzyl-2H-chromene can be isolated from the dried heartwood of Caesalpinia sappan L. 7,3',4'-Trihydroxy-3-benzyl-2H-chromene has potent NAs inhibitory activities with IC50 values of 34.6 µM [H1N1], 39.5 µM [H3N2], and 50.5µM [H9N2], respectively. 7,3',4'-Trihydroxy-3-benzyl-2H-chromene can be used for the research of influenza virus.
  • HY-N4299
    Caesappanin C 1913319-59-1
    Caesappanin C, a biphenyl dimer from the ethanolic extract of the heartwood of Indonesian Caesalpinia sappan L., shows strong proliferation stimulating activity against the primary osteoblastic cells in vitro. Caesappanin C has the potential to stimulate bone formation and regeneration.
    Caesappanin C
  • HY-N9316
    3'-Deoxy-4-O-methylsappanol 112408-68-1
    3'-Deoxy-4-O-methylsappanol shows cytotoxicity against melanoma HMV II cell (IC50=50.4 μM) and has significant anti-melanogenic activities (EC50=72 μM).
  • HY-N9539
    Phanginin A 1011528-58-7
    Phanginin A is a potent and orally active SIK1 (salt-induced kinase 1) activator. Phanginin A inhibited gluconeogenesis. Phanginin A increases the expression of p-SIK1 and decreases the expression of p-CREB. Phanginin A reduces blood glucose levels and improves glucose tolerance and dyslipidemia. Phanginin A has the potential for the research of type 2 diabetes.
    Phanginin A
  • HY-N2640
    4-O-Methylsappanol 104778-16-7
    4-O-Methylsappanol is a natural isoflavonoid with antifungal activities. 4-O-Methylsappanol shows activity against Beauveria bassiana. 4-O-Methylsappanol (EC50 of 4.6 μM) strongly suppresses Melanin (Melanin) synthesis in HMV-II cells.