1. Epigenetics
    Stem Cell/Wnt
    JAK/STAT Signaling
  2. JAK
    STAT
  3. Protosappanin A

Protosappanin A (Synonyms: PTA)

Cat. No.: HY-113573 Purity: 98.88%
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Protosappanin A (PTA), an immunosuppressive ingredient and major biphenyl compound isolated from Caesalpinia sappan L, suppresses JAK2/STAT3-dependent inflammation pathway through down-regulating the phosphorylation of JAK2 and STAT3.

For research use only. We do not sell to patients.

Protosappanin A Chemical Structure

Protosappanin A Chemical Structure

CAS No. : 102036-28-2

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Description

Protosappanin A (PTA), an immunosuppressive ingredient and major biphenyl compound isolated from Caesalpinia sappan L, suppresses JAK2/STAT3-dependent inflammation pathway through down-regulating the phosphorylation of JAK2 and STAT3[1].

IC50 & Target[1]

JAK2

 

STAT3

 

In Vitro

Protosappanin A (PTA: 12.5, 25, 50 μM, 24 hours) significantly inhibits the production of TNF-α and IL-1β in LPS-activated BV2 microglia. And the mRNA expressions of IL-6, IL-1β, and MCP-1 are reduced by PTA in a dose-dependent manner in BV2 microglial cell line[1].
Protosappanin A (PTA: 12.5, 25, 50 μM, 24 hours) suppresses JAK2/STAT3-dependent inflammation pathway through down-regulating the phosphorylation of JAK2 and STAT3, as well as STAT3 nuclear translocation against LPS treatment[1].
Protosappanin A (PTA: 12.5, 25, 50 μM, 24 hours) shows obvious effect on disturbing the interaction of transmembrane protein CD14 with Toll-like receptor-4, resulting in the inhibition of NF-κB-dependent oxidative and nitrative stress in LPS-induced BV2 microglia[2].

Western Blot Analysis[1]

Cell Line: Murine BV2 microglial cell line.
Concentration: 12.5, 25, 50 μM.
Incubation Time: 24 hours.
Result: Inhibits the releases of NO, TNF-α and IL-1β in LPS-induced BV2 cells.
Attenuated IL-6, IL-1β and MCP-1 gene expressions in the LPS-induced BV2 cells.
Suppressed JAK2/STAT3 pathway activation in the LPS-induced BV2 cells.
Clinical Trial
Molecular Weight

272.25

Formula

C₁₅H₁₂O₅

CAS No.

102036-28-2

SMILES

O=C1CC2=CC(O)=C(O)C=C2C3=CC=C(O)C=C3OC1

Shipping

Room temperature in continental US; may vary elsewhere

Storage

4°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

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Protosappanin A
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