1. Apoptosis
  2. Apoptosis
  3. Sappanchalcone

Sappanchalcone 

Cat. No.: HY-59001
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Sappanchalcone, a flavonoid isolated from Caesalpinia sappan L., induces caspase-dependent and AIF-dependent apoptosis in human colon cancer cells.

For research use only. We do not sell to patients.

Sappanchalcone Chemical Structure

Sappanchalcone Chemical Structure

CAS No. : 94344-54-4

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Description

Sappanchalcone, a flavonoid isolated from Caesalpinia sappan L., induces caspase-dependent and AIF-dependent apoptosis in human colon cancer cells[1].

In Vitro

Sappanchalcone has a statistically significant effect on HCT116 cells than on SW480 cells (IC50= 37.33 μM and 54.23 μM, respectively). Sappanchalcone reduces MMP with a significant increase in ROS levels in human colon cancer cells. Sappanchalcone triggered phosphorylation of p53, which is involved in the activation of caspases and increased expression of Bax in HCT116 cells[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

286.28

Formula

C₁₆H₁₄O₅

CAS No.
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Sappanchalcone
Cat. No.:
HY-59001
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