2. Membrane Transporter/Ion Channel
  3. Proton Pump
  4. PF 03716556

PF 03716556 is a potent, selective, competitive and reversible acid pump (H+,K+-ATPase) antagonist with pIC50s of 6.026, 6.038 and 6.009 for porcine, canine, and human recombinant gastric H+,K+-ATPase, respectively. PF 03716556 is inactive against other receptors, ion channels, and enzymes. PF 03716556 has the potential for gastroesophageal reflux disease research.

商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
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PF 03716556

PF 03716556 構造式

CAS 番号 : 928774-43-0

容量 価格（税別） 在庫状況 数量
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
 USD 75 在庫あり
Solution
10 mM * 1 mL in DMSO USD 75 在庫あり
Solid
5 mg $69 在庫あり
10 mg $108 在庫あり
25 mg $216 在庫あり
50 mg $408 在庫あり
100 mg $768 在庫あり
200 mg   お問い合わせ  
500 mg   お問い合わせ  

* アイテムを追加する前、数量をご選択ください

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Other Forms of PF 03716556:

PF 03716556 関連抗体

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製品説明

PF 03716556 is a potent, selective, competitive and reversible acid pump (H+,K+-ATPase) antagonist with pIC50s of 6.026, 6.038 and 6.009 for porcine, canine, and human recombinant gastric H+,K+-ATPase, respectively. PF 03716556 is inactive against other receptors, ion channels, and enzymes. PF 03716556 has the potential for gastroesophageal reflux disease research[1].

IC50 & Target

pIC50: 6.026 (Porcine gastric H+,K+-ATPase), 6.038 (Canine gastric H+,K+-ATPase) and 6.009 (Recombinant gastric H+,K+-ATPase)[1]
体外実験

In porcine ion-tight membrane vesicles, PF 03716556 inhibits H+,K+-ATPase activity in a concentration-dependent manner, with a pIC50 value of 7.095 at pH 7.4[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

PF 03716556 関連抗体
体内実験

PF 03716556 (1-10 mg/kg; intraduodenal administration; once; male Sprague-Dawley rats) treatment inhibits gastric acid secretion in a dose-dependent manner in rats[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male Sprague-Dawley rats (250 -300 g) treated with Pentagastrin[1]
Dosage: 1 mg/kg, 3 mg/kg, 10 mg/kg
Administration: Intraduodenal administration; once
Result: Inhibited gastric acid secretion in a dose-dependent manner.
分子量

394.47

分子式

C22H26N4O3
CAS 番号
Appearance

Solid

Color

White to yellow

SMILES

CC1=CN2C=C(C=C(C2=N1)N[C@H]3C4=C(C=CC=C4OCC3)C)C(N(CCO)C)=O
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
溶剤 & 溶解度
体外: 

DMSO : 23 mg/mL (58.31 mM; Need ultrasonic and warming; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.5350 mL 12.6752 mL 25.3505 mL
5 mM 0.5070 mL 2.5350 mL 5.0701 mL
10 mM 0.2535 mL 1.2675 mL 2.5350 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

一般には略語で表示されます：C1V1 = C2V2

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In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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純度とドキュメンテーション
参考文献

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.5350 mL 12.6752 mL 25.3505 mL 63.3762 mL
5 mM 0.5070 mL 2.5350 mL 5.0701 mL 12.6752 mL
10 mM 0.2535 mL 1.2675 mL 2.5350 mL 6.3376 mL
15 mM 0.1690 mL 0.8450 mL 1.6900 mL 4.2251 mL
20 mM 0.1268 mL 0.6338 mL 1.2675 mL 3.1688 mL
25 mM 0.1014 mL 0.5070 mL 1.0140 mL 2.5350 mL
30 mM 0.0845 mL 0.4225 mL 0.8450 mL 2.1125 mL
40 mM 0.0634 mL 0.3169 mL 0.6338 mL 1.5844 mL
50 mM 0.0507 mL 0.2535 mL 0.5070 mL 1.2675 mL
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PF 03716556 Related Classifications

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

質量   濃度   体積   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

一般には略語で表示されます：C1V1 = C2V2

濃度 （開始） × 体積 （開始） = 濃度 （終了） × 体積 （終了）
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PF 03716556928774-43-0PF03716556PF-03716556Proton PumpAcidpumpH+,K+-ATPasesecretiongastroesophagealrefluxInhibitorinhibitorinhibit

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製品名:
PF 03716556
製品番号:
HY-13100
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