1. Metabolic Enzyme/Protease
  2. Angiotensin-converting Enzyme (ACE)
  3. Pivalopril

Pivalopril (Synonyms: Pivopril; RHC 3659(S))

Cat. No.: HY-U00041
Handling Instructions

Pivalopril is a new orally active angiotensin converting enzyme (ACE) inhibitor.

For research use only. We do not sell to patients.

Pivalopril Chemical Structure

Pivalopril Chemical Structure

CAS No. : 81045-50-3

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Description

Pivalopril is a new orally active angiotensin converting enzyme (ACE) inhibitor.

IC50 & Target

ACE[1]

In Vivo

Pivalopril is a new compound with a hindered sulfur group that has been compared to Captopril for oral angiotensin-converting enzyme (ACE) inhibition in rats and dogs and antihypertensive activity in rats. In separate groups of conscious normotensive rats, Pivalopril (0.03-1.0 mg/kg, orally [p.o.]) produces a dose-related antagonism of angiotensin I (AngI)-induced pressor effects. The ED50 for Pivalopril and Captopril is 0.1 mg/kg. In conscious normotensive dogs, Pivalopril (incremental doses of 0.01-1.0 mg/kg, p.o.) produces a dose-related antagonism of AngI pressor effects. The ED50 is 0.17 mg/kg for Pivalopril and 0.06 mg/kg for Captopril. At equieffective doses the two compounds have similar durations of action. In sodium-deficient, conscious spontaneously hypertensive rats (SHR), Pivalopril (1-100 mg/kg, p.o.) produces a dose-related reduction in mean arterial pressure. The potency and duration are similar to those of Captopril. In the sodium-replete SHR, 5 days of oral dosing with Pivalopril (100 mg/kg per day) decreases mean arterial pressure more effectively than Captopril (100 mg/kg per day). It is concluded that Pivalopril is a potent, orally effective ACE inhibitor and antihypertensive agent[2].

Molecular Weight

329.45

Formula

C₁₆H₂₇NO₄S

CAS No.

81045-50-3

SMILES

O=C(O)CN(C1CCCC1)C([[email protected]](C)CSC(C(C)(C)C)=O)=O

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Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

PivaloprilPivopril RHC 3659(S)Angiotensin-converting Enzyme (ACE)Inhibitorinhibitorinhibit

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