1. GPCR/G Protein
    Neuronal Signaling
  2. 5-HT Receptor
  3. RU 24969

RU 24969 

Cat. No.: HY-16688 Purity: 99.97%
Handling Instructions

RU 24969 is a preferential 5-HT1B agonist, with a Ki of 0.38 nM, but also displays appreciable affinity for the 5-HT1A receptor (Ki=2.5 nM), and has low affinity for other receptor sites in the brain. RU 24969 could decrease fluid consumption and increase forward locomotion.

For research use only. We do not sell to patients.

RU 24969 Chemical Structure

RU 24969 Chemical Structure

CAS No. : 66611-26-5

Size Price Stock Quantity
Free Sample (0.5-1 mg)   Apply Now  
Solution
10 mM * 1 mL in DMSO USD 79 In-stock
Estimated Time of Arrival: December 31
Solid + Solvent
10 mM * 1 mL
ready for reconstitution
USD 79 In-stock
Estimated Time of Arrival: December 31
Solid
5 mg USD 72 In-stock
Estimated Time of Arrival: December 31
10 mg USD 102 In-stock
Estimated Time of Arrival: December 31
50 mg USD 360 In-stock
Estimated Time of Arrival: December 31
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Customer Review

Based on 1 publication(s) in Google Scholar

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Description

RU 24969 is a preferential 5-HT1B agonist, with a Ki of 0.38 nM, but also displays appreciable affinity for the 5-HT1A receptor (Ki=2.5 nM), and has low affinity for other receptor sites in the brain. RU 24969 could decrease fluid consumption and increase forward locomotion[1].

IC50 & Target[1]

5-HT1B Receptor

0.38 nM (Ki)

5-HT1A Receptor

2.5 nM (Ki)

In Vitro

RU 24969 (10 μM) reduces K+-stimulated release of [3H]-5-HT from ratfrontalcortex slices in vitro[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

RU 24969 (0.03-3.0 mg/kg; s.c.) dose-dependently decreases water consumption in water deprived rats[1].
RU 24969 (0.3-3.0 mg/kg; s.c.) dose-dependently increases forward locomotion[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male Sprague-Dawley rats[1]
Dosage: 0.03, 0.3, 1.0, 3.0 mg/kg
Administration: A single s.c.
Result: Decreased water consumption significantly at dose of 0.3, 1.0, and 3.0 mg/kg.
Molecular Weight

228.29

Formula

C₁₄H₁₆N₂O

CAS No.
SMILES

COC1=CC=C2C(C(C3=CCNCC3)=CN2)=C1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : ≥ 30 mg/mL (131.41 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 4.3804 mL 21.9020 mL 43.8039 mL
5 mM 0.8761 mL 4.3804 mL 8.7608 mL
10 mM 0.4380 mL 2.1902 mL 4.3804 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (10.95 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.5 mg/mL (10.95 mM); Clear solution

*All of the co-solvents are provided by MCE.
References

Purity: 99.97%

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This equation is commonly abbreviated as: C1V1 = C2V2

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× = ×
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Keywords:

RU 24969RU24969RU-249695-HT ReceptorSerotonin Receptor5-hydroxytryptamine Receptor5-HT1B5-HT1AfluidlocomotionInhibitorinhibitorinhibit

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Product Name:
RU 24969
Cat. No.:
HY-16688
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