1. GPCR/G Protein Neuronal Signaling
  2. 5-HT Receptor
  3. RU 24969

RU 24969 

Cat. No.: HY-16688 Purity: 99.97%
COA Handling Instructions

RU 24969 is a preferential 5-HT1B agonist, with a Ki of 0.38 nM, but also displays appreciable affinity for the 5-HT1A receptor (Ki=2.5 nM), and has low affinity for other receptor sites in the brain. RU 24969 could decrease fluid consumption and increase forward locomotion.

For research use only. We do not sell to patients.

RU 24969 Chemical Structure

RU 24969 Chemical Structure

CAS No. : 66611-26-5

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Solid + Solvent
10 mM * 1 mL in DMSO
ready for reconstitution
USD 79 In-stock
Solution
10 mM * 1 mL in DMSO USD 79 In-stock
Solid
5 mg USD 72 In-stock
10 mg USD 102 In-stock
50 mg USD 360 In-stock
100 mg USD 550 In-stock
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Customer Review

Based on 1 publication(s) in Google Scholar

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Top Publications Citing Use of Products

1 Publications Citing Use of MCE RU 24969

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  • References

  • Customer Review

Description

RU 24969 is a preferential 5-HT1B agonist, with a Ki of 0.38 nM, but also displays appreciable affinity for the 5-HT1A receptor (Ki=2.5 nM), and has low affinity for other receptor sites in the brain. RU 24969 could decrease fluid consumption and increase forward locomotion[1].

IC50 & Target[1]

5-HT1B Receptor

0.38 nM (Ki)

5-HT1A Receptor

2.5 nM (Ki)

In Vitro

RU 24969 (10 μM) reduces K+-stimulated release of [3H]-5-HT from ratfrontalcortex slices in vitro[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

RU 24969 (0.03-3.0 mg/kg; s.c.) dose-dependently decreases water consumption in water deprived rats[1].
RU 24969 (0.3-3.0 mg/kg; s.c.) dose-dependently increases forward locomotion[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male Sprague-Dawley rats[1]
Dosage: 0.03, 0.3, 1.0, 3.0 mg/kg
Administration: A single s.c.
Result: Decreased water consumption significantly at dose of 0.3, 1.0, and 3.0 mg/kg.
Molecular Weight

228.29

Formula

C14H16N2O

CAS No.
Appearance

Solid

Color

Light yellow to yellow

SMILES

COC1=CC=C2C(C(C3=CCNCC3)=CN2)=C1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 2 years
-20°C 1 year
Solvent & Solubility
In Vitro: 

DMSO : ≥ 30 mg/mL (131.41 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 4.3804 mL 21.9020 mL 43.8039 mL
5 mM 0.8761 mL 4.3804 mL 8.7608 mL
10 mM 0.4380 mL 2.1902 mL 4.3804 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% Saline

    Solubility: ≥ 2.5 mg/mL (10.95 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in Saline)

    Solubility: ≥ 2.5 mg/mL (10.95 mM); Clear solution

*All of the co-solvents are available by MedChemExpress (MCE).
Purity & Documentation

Purity: 99.97%

References
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RU 24969 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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This equation is commonly abbreviated as: C1V1 = C2V2

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Product Name:
RU 24969
Cat. No.:
HY-16688
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