RU 24969 succinate

Name: RU 24969 succinate
Brand: MedChemExpress
SKU: HY-16688A
Rating: 4.5 (1 reviews)

Cat. No.: HY-16688A Purity: 99.58%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

RU 24969 succinate is a 5-HT receptor agonist with K_i values of 0.38 and 2.5 nM for 5-HT_1B and 5-HT_1A, respectively. RU 24969 decreases fluid consumption and increases forward locomotion. RU 24969 succinate can be used for the research of neurological disease.

For research use only. We do not sell to patients.

RU 24969 succinate Chemical Structure

CAS No. : 107008-28-6

Size	Price	Stock	Quantity
Free Sample (0.1 - 0.5 mg)		Apply Now
5 mg	USD 72	In-stock	Estimated Time of Arrival: December 31
10 mg	USD 102	In-stock	Estimated Time of Arrival: December 31
50 mg	USD 360	In-stock	Estimated Time of Arrival: December 31
100 mg	USD 550	In-stock	Estimated Time of Arrival: December 31
200 mg		Get quote
500 mg		Get quote

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Customer Review

Based on 1 publication(s) in Google Scholar

Other Forms of RU 24969 succinate:

RU 24969 In-stock

1 Publications Citing Use of MCE RU 24969 succinate

•Behav Brain Funct. 2021 May 18;17(1):4. [Abstract]

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Biological Activity
Purity & Documentation
Customer Review

Description

IC₅₀ & Target

Ki: 0.38 nM (5-HT1B), 2.5 nM (5-HT1A)^[3]

In Vitro

RU 24969 succinate (30 nM-1 μM) dose-dependently inhibits K⁺ evoked efflux of tritium and shows a pD₂ value of 7.45 for the maximum effect at 1 μM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

RU 24969 succinate (1 and 3 mg/kg; s.c., once) potentiates addictive agent-induced effects^[2].
RU 24969 succinate (0.03-3.0 mg/kg; s.c., once) dose-dependently decreases water consumption in water deprived rats^[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Male Wistar rats with cocaine injection^[2]
Dosage:	1 and 3 mg/kg
Administration:	Subcutaneous injection; 1 and 3 mg/kg, once
Result:	Increased cocaine-induced elevation of nucleus accumbens (NAcc) dopamine DA levels and reduction of ventral tegmental area (VTA) GABA levels.

Molecular Weight

346.38

Formula

C₁₈H₂₂N₂O₅

CAS No.

107008-28-6

Appearance

Solid

Color

Light yellow to yellow

SMILES

O=C(O)CCC(O)=O.COC1=CC=C2C(C(C3=CCNCC3)=CN2)=C1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 120 mg/mL (346.44 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.8870 mL	14.4350 mL	28.8700 mL
5 mM	0.5774 mL	2.8870 mL	5.7740 mL
10 mM	0.2887 mL	1.4435 mL	2.8870 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 99.58%

Select Batch:

Data Sheet (278 KB) SDS (251 KB)

COA (253 KB) HNMR (420 KB) LCMS (94 KB)

Handling Instructions (2659 KB)

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	2.8870 mL	14.4350 mL	28.8700 mL	72.1751 mL
	5 mM	0.5774 mL	2.8870 mL	5.7740 mL	14.4350 mL
	10 mM	0.2887 mL	1.4435 mL	2.8870 mL	7.2175 mL
	15 mM	0.1925 mL	0.9623 mL	1.9247 mL	4.8117 mL
	20 mM	0.1444 mL	0.7218 mL	1.4435 mL	3.6088 mL
	25 mM	0.1155 mL	0.5774 mL	1.1548 mL	2.8870 mL
	30 mM	0.0962 mL	0.4812 mL	0.9623 mL	2.4058 mL
	40 mM	0.0722 mL	0.3609 mL	0.7218 mL	1.8044 mL
	50 mM	0.0577 mL	0.2887 mL	0.5774 mL	1.4435 mL
	60 mM	0.0481 mL	0.2406 mL	0.4812 mL	1.2029 mL
	80 mM	0.0361 mL	0.1804 mL	0.3609 mL	0.9022 mL
	100 mM	0.0289 mL	0.1444 mL	0.2887 mL	0.7218 mL

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

RU 24969107008-28-6RU24969RU-24969Inhibitorinhibitorinhibit

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RU 24969 succinate

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