2. GPCR/G Protein Neuronal Signaling
  3. 5-HT Receptor
  4. RU 24969 hemisuccinate

RU 24969 hemisuccinate is a preferential 5-HT1B agonist, with a Ki of 0.38 nM, but also displays appreciable affinity for the 5-HT1A receptor (Ki=2.5 nM), and has low affinity for other receptor sites in the brain. RU 24969 hemisuccinate could decrease fluid consumption and increase forward locomotion.

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RU 24969 hemisuccinate Chemical Structure

RU 24969 hemisuccinate Chemical Structure

CAS No. : 66611-27-6

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RU 24969 hemisuccinate Related Antibodies

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Description

RU 24969 hemisuccinate is a preferential 5-HT1B agonist, with a Ki of 0.38 nM, but also displays appreciable affinity for the 5-HT1A receptor (Ki=2.5 nM), and has low affinity for other receptor sites in the brain. RU 24969 hemisuccinate could decrease fluid consumption and increase forward locomotion[1].

IC50 & Target[1]

5-HT1B Receptor

0.38 nM (Ki)

5-HT1A Receptor

2.5 nM (Ki)

In Vitro

RU 24969 (10 μM) reduces K+-stimulated release of [3H]-5-HT from ratfrontalcortex slices in vitro[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

RU 24969 hemisuccinate Related Antibodies
In Vivo

RU 24969 (0.03-3.0 mg/kg; s.c.) dose-dependently decreases water consumption in water deprived rats[1].
RU 24969 (0.3-3.0 mg/kg; s.c.) dose-dependently increases forward locomotion[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male Sprague-Dawley rats[1]
Dosage: 0.03, 0.3, 1.0, 3.0 mg/kg
Administration: A single s.c.
Result: Decreased water consumption significantly at dose of 0.3, 1.0, and 3.0 mg/kg.
Molecular Weight

287.34

Formula

C14H16N2O.1/2C4H6O4
CAS No.
SMILES

O=C(O)CCC(O)=O.COC1=CC=C2C(C(C3=CCNCC3)=CN2)=C1.[1/2]
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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RU 24969 hemisuccinate Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

RU 24969 hemisuccinate66611-27-65-HT ReceptorSerotonin Receptor5-hydroxytryptamine Receptor5-HT1B5-HT1AfluidlocomotionInhibitorinhibitorinhibit

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