1. GPCR/G Protein
    Neuronal Signaling
  2. 5-HT Receptor
  3. RU 24969 hemisuccinate

RU 24969 hemisuccinate 

Cat. No.: HY-16688B
Handling Instructions

RU 24969 hemisuccinate is a preferential 5-HT1B agonist, with a Ki of 0.38 nM, but also displays appreciable affinity for the 5-HT1A receptor (Ki=2.5 nM), and has low affinity for other receptor sites in the brain. RU 24969 hemisuccinate could decrease fluid consumption and increase forward locomotion.

For research use only. We do not sell to patients.

RU 24969 hemisuccinate Chemical Structure

RU 24969 hemisuccinate Chemical Structure

CAS No. : 66611-27-6

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Description

RU 24969 hemisuccinate is a preferential 5-HT1B agonist, with a Ki of 0.38 nM, but also displays appreciable affinity for the 5-HT1A receptor (Ki=2.5 nM), and has low affinity for other receptor sites in the brain. RU 24969 hemisuccinate could decrease fluid consumption and increase forward locomotion[1].

IC50 & Target[1]

5-HT1B Receptor

0.38 nM (Ki)

5-HT1A Receptor

2.5 nM (Ki)

In Vitro

RU 24969 (10 μM) reduces K+-stimulated release of [3H]-5-HT from ratfrontalcortex slices in vitro[2].

In Vivo

RU 24969 (0.03-3.0 mg/kg; s.c.) dose-dependently decreases water consumption in water deprived rats[1].
RU 24969 (0.3-3.0 mg/kg; s.c.) dose-dependently increases forward locomotion[1].

Animal Model: Male Sprague-Dawley rats[1]
Dosage: 0.03, 0.3, 1.0, 3.0 mg/kg
Administration: A single s.c.
Result: Decreased water consumption significantly at dose of 0.3, 1.0, and 3.0 mg/kg.
Molecular Weight

287.34

Formula

C₁₄H₁₆N₂O.₁/₂C₄H₆O₄

CAS No.

66611-27-6

SMILES

O=C(O)CCC(O)=O.COC1=CC=C2C(C(C3=CCNCC3)=CN2)=C1.[1/2]

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

RU 24969 hemisuccinate5-HT ReceptorSerotonin Receptor5-hydroxytryptamine Receptor5-HT1B5-HT1AfluidlocomotionInhibitorinhibitorinhibit

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RU 24969 hemisuccinate
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HY-16688B
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