RU 24969 hemisuccinate
Based on 3 publication(s) in Google Scholar
RU 24969 hemisuccinate is a preferential 5-HT1B agonist, with a Ki of 0.38 nM, but also displays appreciable affinity for the 5-HT1A receptor (Ki=2.5 nM), and has low affinity for other receptor sites in the brain. RU 24969 hemisuccinate could decrease fluid consumption and increase forward locomotion.
For research use only. We do not sell to patients.
- CAS No.: 66611-27-6
- Formula: C14H16N2O.1/2C4H6O4
- Molecular Weight:287.34
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Publications Citing Use of MedChemExpress (MCE) RU 24969 hemisuccinate
MoreAll 5-HT Receptor Isoforms
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Biological Activity
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5-HT1B Receptor 0.38 nM (Ki) |
5-HT1A Receptor 2.5 nM (Ki) |
RU 24969 (10 μM) reduces K+-stimulated release of [3H]-5-HT from ratfrontalcortex slices in vitro[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
RU 24969 (0.3-3.0 mg/kg; s.c.) dose-dependently increases forward locomotion[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Male Sprague-Dawley rats[1]
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Dosage:0.03, 0.3, 1.0, 3.0 mg/kg
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Administration:A single s.c.
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Result:Decreased water consumption significantly at dose of 0.3, 1.0, and 3.0 mg/kg.
Chemical Information
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CAS No. 66611-27-6
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Molecular Weight 287.34
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Formula C14H16N2O.1/2C4H6O4
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SMILES
O=C(O)CCC(O)=O.COC1=CC=C2C(C(C3=CCNCC3)=CN2)=C1.[1/2]
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Publications (3)
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Journal Impact Factor
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Most Recent
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Behav Brain Funct
Distinct behavioral traits and associated brain regions in mouse models for obsessive-compulsive disorder. [Abstract]2021 May 18;17(1):4. PMID: 34006308 -
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Purity & Documentation
References
[1]. Aronsen D, et, al. RU 24969-produced adipsia and hyperlocomotion: differential role of 5HT 1A and 5HT 1B receptor mechanisms. Pharmacol Biochem Behav. 2014 Sep; 124: 1-4. [Content Brief]
[2]. Brazell MP, et, al. The 5-HT1 receptor agonist RU-24969 decreases 5-hydroxytryptamine (5-HT) release and metabolism in the rat frontal cortex in vitro and in vivo. Br J Pharmacol. 1985 Sep; 86(1): 209-16. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
RU 24969 hemisuccinate Related Classifications
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