2. GPCR/G Protein Neuronal Signaling
  3. Orexin Receptor (OX Receptor)
  4. Orexin A (human, rat, mouse)

Orexin A (human, rat, mouse)  (Synonyms: Hypocretin-1 (human, rat, mouse))

Cat. No.: HY-106224 Pureté: 97.53%
COA
SDS
Instruction de manipulation Technical Support

Orexin A (human, rat, mouse) (Hypocretin-1 (human, rat, mouse)), a 33 amino acid excitatory neuropeptide, orchestrates diverse central and peripheral processes. Orexin A (human, rat, mouse) binds and activates two types of G protein-coupled receptors, the orexin-1 receptor (OX1R) and the orexin-2 receptor (OX2R). Orexin A (human, rat, mouse) has a role in the regulation of feeding behavior. Orexin A (human, rat, mouse) is an effective anti-nociceptive and anti-hyperalgesic agent in mice and rats.

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Synthèse de peptides personnalisée

CAS No. : 205640-90-0

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Based on 11 publication(s) in Google Scholar

Other Forms of Orexin A (human, rat, mouse):

Orexin A (human, rat, mouse) Related Antibodies

Top Publications Citing Use of Products

    Orexin A (human, rat, mouse) purchased from MedChemExpress. Usage Cited in: CNS Neurosci Ther. 2024 Nov;30(11):e70096.  [Abstract]

    Orexin A (human, rat, mouse) treatment attenuates hippocampal neuronal damage after CLP. Intranasal administration of 250 μg/kg of Orexin A (human, rat, mouse) drug, 2.5 μL per nostril, and 5.0 μL per mouse was used in this experiment. TUNEL staining showing neuronal apoptosis and quantification of TUNEL (green) with DAPI (blue) in the CA1 area of the hippocampus 7 days after CLP.

    Orexin A (human, rat, mouse) purchased from MedChemExpress. Usage Cited in: Research (Wash D C). 2024 May 31:7:0384.  [Abstract]

    Schematic illustration of the effect of different concentrations of Orexin A (human, rat, mouse) on inflammatory factors expression in BV2. In addition, the mRNA expression of TNF-α, IL-6, IL-1β, and inducible nitric oxide synthase (iNOS) in different groups.

    Orexin A (human, rat, mouse) purchased from MedChemExpress. Usage Cited in: J Neuroinflammation. 2024 May 17;21(1):131.  [Abstract]

    Treatment with 250 µg/kg Orexin A (human, rat, mouse) increases 7-day survival. Orexin A (human, rat, mouse) was administered at 250 µg/kg, 30 min after CLP induction, in a volume of 2.5 µl per nostril (5.0 µl per mouse).

    Orexin A (human, rat, mouse) purchased from MedChemExpress. Usage Cited in: J Neuroinflammation. 2024 May 17;21(1):131.  [Abstract]

    Treatment with 250 µg/kg Orexin A (human, rat, mouse) ameliorates cognitive and affective deficits in CLP-induced sepsis. Time in the central zone and distance of activity in the open field. Orexin A (human, rat, mouse) was administered at 250 µg/kg, 30 min after CLP induction, in a volume of 2.5 µl per nostril (5.0 µl per mouse).

    Orexin A (human, rat, mouse) purchased from MedChemExpress. Usage Cited in: J Neuroinflammation. 2024 May 17;21(1):131.  [Abstract]

    Orexin A (human, rat, mouse) reduces inflammation by decreasing Rras expression and impeding activation of the RAS/MAPK pathway.

    Voir tous les produits spécifiques à Isoform Orexin Receptor (OX Receptor):

    Voir toutes les isoformes
    OX2 Receptor OX1 Receptor

    • Activité biologique

    • Pureté et documentation

    • Références

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    Description

    Orexin A (human, rat, mouse) (Hypocretin-1 (human, rat, mouse)), a 33 amino acid excitatory neuropeptide, orchestrates diverse central and peripheral processes. Orexin A (human, rat, mouse) binds and activates two types of G protein-coupled receptors, the orexin-1 receptor (OX1R) and the orexin-2 receptor (OX2R). Orexin A (human, rat, mouse) has a role in the regulation of feeding behavior. Orexin A (human, rat, mouse) is an effective anti-nociceptive and anti-hyperalgesic agent in mice and rats[1][2].

    IC50 & Target

    OX1 Receptor

     

    OX2 Receptor

     

    In Vitro

    Orexin A (human, rat, mouse) has high affinity for OX1R and OX2R, with 38 nM IC50 and 34 nM EC50 values in the the [Ca2﹢]i transient assay[1].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    Orexin A (human, rat, mouse) Related Antibodies
    In Vivo

    Orexin A (human, rat, mouse) (3-30 mg/kg; i.v.; 5 min pre-test) significantly increases the latency to response at 10 and 30 mg/kg i.v. when given 5 min pre-test from 24.8±2.0 s in vehicle-treated mice to 35.0±3.7 s and 45.7±4.5 s, respectively[2].
    Orexin A (human, rat, mouse) (3, 10 and 30 mg/kg; i.v.) was given immediately before phenylp-quinone (PPQ) and increases the latency to the first PPQ-induced constriction from 357.4±35.2 s in vehicle-treated mice to 500.3±31.2 s at 10 mg/kg and 594.5±5.5 s at 30 mg/kg[2].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    Animal Model: Female mice (mouse carrageenan-induced thermal hyperalgesia test)[2]
    Dosage: 3, 10 and 30 mg/kg
    Administration: i.v.; 5 min pre-test
    Result: Significantly increased the latency to response at 10 and 30 mg/kg.
    Masse moléculaire

    3561.10

    Formule

    C152H243N47O44S4
    CAS No.
    Appearance

    Solid

    Color

    White to off-white

    Sequence

    {Glp}-Pro-Leu-Pro-Asp-Cys-Cys-Arg-Gln-Lys-Thr-Cys-Ser-Cys-Arg-Leu-Tyr-Glu-Leu-Leu-His-Gly-Ala-Gly-Asn-His-Ala-Ala-Gly-Ile-Leu-Thr-Leu-NH2 (Disulfide bridge: Cys6-Cys12, Cys7-Cys14)
    Sequence Shortening

    {Glp}-PLPDCCRQKTCSCRLYELLHGAGNHAAGILTL-NH2 (Disulfide bridge: Cys6-Cys12, Cys7-Cys14)
    Livraison

    Room temperature in continental US; may vary elsewhere.
    Stockage

    Sealed storage, away from moisture

    Powder -80°C 2 years
    -20°C 1 year

    *In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

    Solvant et solubilité
    In Vitro: 

    DMSO : 100 mg/mL (28.08 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 0.2808 mL 1.4041 mL 2.8081 mL
    5 mM 0.0562 mL 0.2808 mL 0.5616 mL
    View the Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

    • Calculateur de molarité

    • Calculateur de dilution

    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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    Volume
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    Molecular Weight *

    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    This equation is commonly abbreviated as: C1V1 = C2V2

    Concentration (start)

    C1

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    Volume (start)

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    Concentration (final)

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    In Vivo Dissolution Calculator
    Please enter the basic information of animal experiments:

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    Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
    Calculation results:
    Working solution concentration: mg/mL
    Pureté et documentation

    Purity: 99.93%

    SDS (252 KB)

    COA (271 KB) LCMS (93 KB) Elemental Analysis Report (129 KB)

    Instruction de manipulation (2659 KB)
    Références

    Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

    Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
    DMSO 1 mM 0.2808 mL 1.4041 mL 2.8081 mL 7.0203 mL
    5 mM 0.0562 mL 0.2808 mL 0.5616 mL 1.4041 mL
    10 mM 0.0281 mL 0.1404 mL 0.2808 mL 0.7020 mL
    15 mM 0.0187 mL 0.0936 mL 0.1872 mL 0.4680 mL
    20 mM 0.0140 mL 0.0702 mL 0.1404 mL 0.3510 mL
    25 mM 0.0112 mL 0.0562 mL 0.1123 mL 0.2808 mL
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    Orexin A (human, rat, mouse) Related Classifications

    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    Orexin A (human, rat, mouse)205640-90-0Hypocretin-1 (human, rat, mouse)Orexin Receptor (OX Receptor)Hypocretin ReceptorHCRT ReceptoraffinityG-protein-coupledreceptorfeedingbehaviornociceptiveanti-hyperalgesicInhibitorinhibitorinhibit

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