2. Endocrinology

Endocrinology (内分泌学)

Endocrinology

関連製品

PDF 21.44 MB

Found in most species of the animal kingdom, the endocrine system consists of glands that secrete hormones, and receptors that detect and react to the hormones. In response to environmental stimuli, the endocrine system secretes hormones and uses them as chemical messengers to orchestrate physiological, developmental and reproductive changes that affect the entire body for a long period of time. In order to maintain the proper functioning of the body through its entire life cycle, the endocrine system utilizes a complex feedback mechanism to fine-tune the balance of hormones in the bloodstream. Even a slight disruption to endocrine system’s function can throw off the delicate balance of hormones in the human body and lead to an endocrine disorder, or endocrine disease, such as diabetes, adrenal insufficiency, hyper- or hypothyroidism, and polycystic ovary syndrome (PCOS).

製品番号 製品名 CAS 番号 純度 構造式
  • HY-P3221
    [Leu3]-Oxytocin 4294-11-5 99.88%
    [Leu3]-Oxytocin, an oxytocin analogue, is derived by structural variation in sequence position 3 replaced by leucine (Leu).
    [Leu3]-Oxytocin
  • HY-P4675
    LHRH free acid 35263-73-1 99.68%
    LHRH (free acid), the luteinizing hormone-releasing hormone, is a neuropeptide hypothalamic. LHRH regulates reproduction. LHRH can be used for the research of cancer.
    LHRH free acid
  • HY-100238
    Antihistamine-1 1186430-60-3 99.08%
    Antihistamine-1 is a H1-antihistamine (Ki=6.9 nM) with acceptable blood-brain barrier penetration and also an inhibitor of CYP2D6 and hERG channel with IC50s of 5.4 and 0.8 μM, respectively.
    Antihistamine-1
  • HY-100635
    Diacetolol 22568-64-5
    Diacetolol is an active metabolite of the beta-adrenoceptor blocking agent Acebutolol (HY-17497).
    Diacetolol
  • HY-101438
    Darbufelone 139226-28-1 ≥98.0%
    Darbufelone is a dual inhibitor of cellular PGF2α and LTB4 production. Darbufelone potently inhibits PGHS-2 (IC50= 0.19 μM) but is much less potent with PGHS-1 (IC50=20 μM).
    Darbufelone
  • HY-101735
    (9Z,11E)-Prodlure 50767-79-8 98.83%
    (9Z,11E)-Prodlure ((9Z,11E)-Tetradecadien-1-yl acetate) is the main component of the sex pheromone of female Spodoptera littoralis.
    (9Z,11E)-Prodlure
  • HY-102093
    ZD 7155hydrochloride 146709-78-6 99.88%
    ZD 7155 hydrochloride is an angiotensin II receptor type 1 (AT1 receptor) antagonist.
    ZD 7155hydrochloride
  • HY-103005
    Ramelteon metabolite M-II 896736-21-3 98.84%
    Ramelteon metabolite M-II is the major metabolite of Ramelteon, with IC50s of 208 pM, 1470 pM for human melatonin receptors (MT1 or MT2). Ramelteon is a selective melatonin agonist.
    Ramelteon metabolite M-II
  • HY-108768
    Pasireotide pamoate 396091-79-5 99.47%
    Pasireotide (SOM230) pamoate, a long-acting cyclohexapeptide somatostatin analogue, can improve agonist activity at somatostatin receptors (subtypes sst1/2/3/4/5, pKi=8.2/9.0/9.1/<7.0/9.9, respectively). Pasireotide pamoate exhibits antisecretory, antiproliferative, and proapoptotic activity.
    Pasireotide pamoate
  • HY-113383
    2-Hydroxyvaleric acid 617-31-2 98.0%
    2-Hydroxyvaleric acid is a medium chain α-hydroxy fatty acid. 2-Hydroxyvaleric acid is an activator in fat metabolism of palmitic acid-1-C14. 2-hydroxyvaleric acid is also used as a staining agent for measuring tissue-specific Lactate dehydrogenase activity and elevated levels of 2-hydroxyvaleric acid induces lactic acidosis.
    2-Hydroxyvaleric acid
  • HY-117851
    AC-265347 1253901-26-6 99.97%
    AC-265347 is a calcium-sensing receptor (CaSR) agonist and positive allosteric modulator (ago-PAM) with the functional affinity (pKB) of 5.1. AC-265347 can be used for the research of hyperparathyroidism and related diseases.
    AC-265347
  • HY-121667
    Scaff10-8 777857-56-4 99.11%
    Scaff10-8 is a RhoA inhibitor. Scaff10-8 binds to RhoA, inhibits AKAP-Lbc-mediated RhoA activation. Scaff10-8 can be used for research on diabetes insipidus and bipolar disorder.
    Scaff10-8
  • HY-125923
    Djenkolic acid 498-59-9 ≥98.0%
    Djenkolic acid is a sulfur-containing amino acid. Djenkolic acid can be isolated from the djenkol beans of the Southeast Asian plant Archidendron jiringa. Djenkolic acid de-inhibits the SO42- uptake system in Pseudomonas fluorescens. Djenkolic acid causes supersaturation of the urinary system with djenkolic acid crystals, leading to urinary tract obstruction and acute kidney injury.
    Djenkolic acid
  • HY-126941
    Hecogenin acetate 915-35-5 98.57%
    Hecogenin acetate is an orally active steroid saponin aglycone with extensive biological activities. Hecogenin acetate inhibits the phosphorylation of NF-κB and p38 MAPK signaling pathways, antagonizes TRPA1/TRPM8 channels, inhibits the production of pro-inflammatory cytokines, and has anti-inflammatory and analgesic effects. Hecogenin acetate inhibits the production of ROS and the activation of NLRP3 inflammasome; downregulates the expression of MMP-2, and has neuroprotective and anti-tumor activities. Hecogenin acetate enhances gastric mucosal defense and promotes ulcer healing. Hecogenin acetate can be used in combination with certain antibiotics to regulate bacterial efflux pumps and restore antibiotic sensitivity.
    Hecogenin acetate
  • HY-128428
    Carboprost 35700-23-3 99.84%
    Carboprost (15(S)-15-Methyl Prostaglandin F2α) is a metabolically stable synthetic analog of prostaglandin F2α. Carboprost stimulates uterine contractions and induces abortion. Carboprost is used for postpartum hemorrhage due to uterine atony and for the termination of pregnancy in the second trimester.
    Carboprost
  • HY-131547
    Org OD 02-0 13258-85-0 99.7%
    Org OD 02-0 (10-Ethenyl-19-norprogesterone) is a membrane progesterone receptor α (mPRα)-specific agonist (IC50: 33.9 nM). Org OD 02-0 activates MAPK activity. Org OD 02-0 inhibits prolactin (PRL) secretion in the pituitary.
    Org OD 02-0
  • HY-13570R
    Betamethasone (Standard) 378-44-9 99.71%
    Betamethasone (Standard) is the analytical standard of Betamethasone. This product is intended for research and analytical applications. Betamethasone is a synthetic glucocorticoid with anti-inflammatory and immunosuppressive activities. Betamethasone accelerates fetal lung maturation and induces gene expression and apoptosis.
    Betamethasone (Standard)
  • HY-13632R
    Exemestane (Standard) 107868-30-4 98.01%
    Exemestane (Standard) is the analytical standard of Exemestane. This product is intended for research and analytical applications. Exemestane (FCE 24304) is a selective, irreversible and orally active steroidal aromatase inhibitor with IC50s of 30 nM and 40 nM for human placental and rat ovarian aromatase, respectively. Exemestane can be used for hormone-dependent breast cancer research.
    Exemestane (Standard)
  • HY-13693S
    Mometasone furoate-d3 98.80%
    Mometasone furoate-d3 is a deuterium labeled Mometasone furoate. Mometasone furoate (Sch32088) is a glucocorticoid receptor agonist with anti-inflammatory and anti-allergic activity.
    Mometasone furoate-d3
  • HY-147203
    5-HT2B antagonist-1 393129-91-4 99.90%
    5-HT2B antagonist-1 is an orally active 5-HT2B receptor antagonist with an IC50 value of 33.4 nM. 5-HT2B antagonist-1 can be used in studies of diseases characterized by 5-HT2B receptor signaling, such as hepatocellular carcinoma, cardiovascular disease or gastrointestinal disease.
    5-HT2B antagonist-1
製品番号 製品名 / Synonyms Application Reactivity