1. GPCR/G Protein
    Neuronal Signaling
  2. Somatostatin Receptor
  3. Pasireotide pamoate

Pasireotide pamoate (Synonyms: SOM230 pamoate)

Cat. No.: HY-108768
Handling Instructions

Pasireotide pamoate (SOM230 pamoate) is a stable cyclohexapeptide somatostatin mimic that improves agonist activity at somatostatin receptors (subtypes sst1/2/3/4/5, pKi=8.2/9.0/9.1/<7.0/9.9 respectively). Pasireotide pamoate exhibits antisecretory, antiproliferative, and proapoptotic activity.

For research use only. We do not sell to patients.

Pasireotide pamoate Chemical Structure

Pasireotide pamoate Chemical Structure

CAS No. : 396091-79-5

Size Stock
100 mg   Get quote  
250 mg   Get quote  
500 mg   Get quote  

* Please select Quantity before adding items.

Other In-stock Forms of Pasireotide pamoate:

Other Forms of Pasireotide pamoate:

Top Publications Citing Use of Products

    Pasireotide pamoate purchased from MCE. Usage Cited in: Am J Pathol. 2018 Apr;188(4):981-994.

    Representative western blot and quantitation of band density show an increase expression of acetylated α-tubulin in PCK cholangiocytes upon ACY-1215 and ACY-1215+Pasireotide treatment.

    Pasireotide pamoate purchased from MCE. Usage Cited in: Hepatology. 2017 Oct;66(4):1197-1218.

    Concurrent treatment of ADPKD cholangiocytes by SBI-115 and Pasireotide decreases cell proliferation, cholangiocyte spheroid growth, and cAMP levels.
    • Biological Activity

    • Purity & Documentation

    • References

    • Customer Review

    Description

    Pasireotide pamoate (SOM230 pamoate) is a stable cyclohexapeptide somatostatin mimic that improves agonist activity at somatostatin receptors (subtypes sst1/2/3/4/5, pKi=8.2/9.0/9.1/<7.0/9.9 respectively). Pasireotide pamoate exhibits antisecretory, antiproliferative, and proapoptotic activity[1][2].

    IC50 & Target

    pKi: 8.2 (sst1), 9.0 (sst2), 9.1 (sst3), <7.0 (sst4), 9.9 (sst5)[1]

    In Vitro

    Pasireotide pamoate exhibits unique high-affinity binding to human somatostatin receptors[1].
    Pasireotide pamoate effectively inhibits the growth hormone releasing hormone (GHRH) induced growth hormone (GH) release in primary cultures of rat pituitary cells with an IC50 of 0.4±0.1 nM[1].

    In Vivo

    Pasireotide pamoate (160mg/Kg/month; s.c.; for 4 months) decreases serum insulin levels and increases serum glucose levels in Pdx1-Cre[2].
    Pasireotide pamoate displays a reduction in tumor activity and reduces Pancreatic Neuroendocrine Tumor (PNET) size in Pdx1-Cre[2].
    Pasireotide pamoate increases apoptosis in PNETs in Pdx1-Cre[2].
    Pasireotide pamoate exerts the antinociceptive and antiinflammatory actions via the SSTR2 receptor in in a mouse model of immune-mediated arthritis[3].

    Animal Model: Eight 12-month old mice carrying the Men1 allele, Men1 floxed/floxed conditional knockout (Pdx1-Cre)[2]
    Dosage: 60mg/kg
    Administration: Subcutaneous injection; very month; for 4 months
    Result: Decreased serum insulin levels and increases serum glucose levels in Pdx1-Cre.
    Clinical Trial
    Molecular Weight

    1435.58

    Formula

    C₈₁H₈₂N₁₀O₁₅

    CAS No.

    396091-79-5

    SMILES

    NCCCC[[email protected]@H](C(N[[email protected]]1CC2=CC=C(C=C2)OCC3=CC=CC=C3)=O)NC([[email protected]](NC([[email protected]](C4=CC=CC=C4)NC([[email protected]]5N(C([[email protected]](CC6=CC=CC=C6)NC1=O)=O)C[[email protected]](OC(NCCN)=O)C5)=O)=O)CC7=CNC8=C7C=CC=C8)=O.OC9=C(C%10=CC=CC=C%10C=C9C(O)=O)CC%11=C(O)C(C(O)=O)=CC%12=CC=CC=C%11%12

    Shipping

    Room temperature in continental US; may vary elsewhere.

    Storage

    Please store the product under the recommended conditions in the Certificate of Analysis.

    References
    • No file chosen (Maximum size is: 1024 Kb)
    • If you have published this work, please enter the PubMed ID.
    • Your name will appear on the site.
    • Molarity Calculator

    • Dilution Calculator

    The molarity calculator equation

    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

    Mass   Concentration   Volume   Molecular Weight *
    = × ×

    The dilution calculator equation

    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    This equation is commonly abbreviated as: C1V1 = C2V2

    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
    × = ×
    C1   V1   C2   V2

    Keywords:

    PasireotideSOM230SOM 230SOM-230Somatostatin ReceptorSSTRsSSTRsomatostatinPancreaticNeuroendocrineTumor,PNETInhibitorinhibitorinhibit

    Your Recently Viewed Products:

    Inquiry Online

    Your information is safe with us. * Required Fields.

    Product name

     

    Salutation

    Applicant name *

     

    Email address *

    Phone number *

     

    Organization name *

    Country or Region *

     

    Requested quantity *

    Remarks

    Bulk Inquiry

    Inquiry Information

    Product name:
    Pasireotide pamoate
    Cat. No.:
    HY-108768
    Quantity:
    MCE Japan Authorized Agent: