Org OD 02-0
Based on 1 Customer Validation
Org OD 02-0 (10-Ethenyl-19-norprogesterone) is a membrane progesterone receptor α (mPRα)-specific agonist (IC50: 33.9 nM). Org OD 02-0 activates MAPK activity. Org OD 02-0 inhibits prolactin (PRL) secretion in the pituitary.
For research use only. We do not sell to patients.
- Purity: 99.7%
- CAS No.: 13258-85-0
- Formula: C22H30O2
- Molecular Weight:326.47
-
Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
-
Biological Activity
-
Chemical Information
-
Solvent & Solubility
- Purity & Documentation
- References
-
Help & FAQs
Biological Activity
33.9 nM (mPRα)[1]
Chemical Information
-
CAS No. 13258-85-0
-
Appearance Solid
-
Molecular Weight 326.47
-
Formula C22H30O2
-
Color White to off-white
-
SMILES
CC([C@H]1CC[C@@]2([H])[C@]3([H])CCC4=CC(CC[C@]4(C=C)[C@@]3([H])CC[C@]12C)=O)=O
-
Synonyms
10-Ethenyl-19-norprogesterone
-
Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
DMSO : 24 mg/mL (73.51 mM; Need ultrasonic and warming; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Ethanol : 3.3 mg/mL (10.11 mM; Need ultrasonic and warming)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
-
Data Sheet (275 KB)
-
SDS (392 KB)
- English - EN (392 KB)
- Français - FR (392 KB)
- Deutsch - DE (392 KB)
- Norwegian - NO (392 KB)
- Español - ES (392 KB)
- Swedish - SV (392 KB)
- Italian - IT (392 KB)
- Korean - KR (392 KB)
- Portuguese - PT (392 KB)
-
Handling Instructions (2659 KB)
References
[1]. Kelder J, et al. Comparison between steroid binding to membrane progesterone receptor alpha (mPRalpha) and to nuclear progesterone receptor: correlation with physicochemical properties assessed by comparative molecular field analysis and identification of mPRalpha-specific agonists. Steroids. 2010 Apr;75(4-5):314-22. [Content Brief]
[2]. Camilletti MA, et al. Participation of membrane progesterone receptor α in the inhibitory effect of progesterone on prolactin secretion. J Neuroendocrinol. 2018 Sep;30(9):e12614. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| Ethanol / DMSO | 1 mM | 3.0631 mL | 15.3153 mL | 30.6307 mL | 76.5767 mL |
| 5 mM | 0.6126 mL | 3.0631 mL | 6.1261 mL | 15.3153 mL | |
| 10 mM | 0.3063 mL | 1.5315 mL | 3.0631 mL | 7.6577 mL | |
| DMSO | 15 mM | 0.2042 mL | 1.0210 mL | 2.0420 mL | 5.1051 mL |
| 20 mM | 0.1532 mL | 0.7658 mL | 1.5315 mL | 3.8288 mL | |
| 25 mM | 0.1225 mL | 0.6126 mL | 1.2252 mL | 3.0631 mL | |
| 30 mM | 0.1021 mL | 0.5105 mL | 1.0210 mL | 2.5526 mL | |
| 40 mM | 0.0766 mL | 0.3829 mL | 0.7658 mL | 1.9144 mL | |
| 50 mM | 0.0613 mL | 0.3063 mL | 0.6126 mL | 1.5315 mL | |
| 60 mM | 0.0511 mL | 0.2553 mL | 0.5105 mL | 1.2763 mL |
Powered by Bioz