1. GPCR/G Protein
  2. Angiotensin Receptor

ZD 7155(hydrochloride) 

Cat. No.: HY-102093
Handling Instructions

ZD 7155 hydrochloride is an angiotensin II receptor type 1 (AT1 receptor) antagonist.

For research use only. We do not sell to patients.

ZD 7155(hydrochloride) Chemical Structure

ZD 7155(hydrochloride) Chemical Structure

CAS No. : 146709-78-6

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  • Biological Activity

  • Protocol

  • Technical Information

  • Purity & Documentation

  • References


ZD 7155 hydrochloride is an angiotensin II receptor type 1 (AT1 receptor) antagonist.

IC50 & Target

Target: AT1 receptor[1]

In Vivo

In conscious SD rats, ZD 7155 and losartan behave as competitive antagonists and the pressor response curve to angiotensin II is shifted to the right. Experiments in conscious SD rats also show that ZD 7155 is approximately ten times as potent as losartan in suppressing the angiotensin II-induced pressor response (240 ng/kg; 10 min infusion). In addition, experiments with conscious rats demonstrate that ZD 7155 could suppress the angiotensin II-induced pressor response for approximately 24 h when ZD 7155 is administered intravenously in a 1.082 μmol/kg bolus dose and angiotensin II is given at 240 ng/kg (in a 10-min infusion). Experiments in conscious SHRs using ZD 7155 (1.082 mumol/kg) and losartan (6.495 mumol/kg) as intravenous boluses indicate that both ZD 7155 and the reference compound losartan exhibit a significant antihypertensive effect[1].

Solvent & Solubility
In Vitro: 

10 mM in DMSO

Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.1053 mL 10.5265 mL 21.0531 mL
5 mM 0.4211 mL 2.1053 mL 4.2106 mL
10 mM 0.2105 mL 1.0527 mL 2.1053 mL
*Please refer to the solubility information to select the appropriate solvent.
Animal Administration


SpragueDawley rat are used. Saline is used as control for the anpiotensin I1 type 1 receptor antagonists. ZD 7155 is given intravenously in a bolus dose of 1.082 pmol/kg, and losartan in the doses 2.165 and 6.495 pmol/kg[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight









Please store the product under the recommended conditions in the Certificate of Analysis.


Room temperature in continental US; may vary elsewhere

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Product Name:
ZD 7155(hydrochloride)
Cat. No.:

ZD 7155(hydrochloride)

Cat. No.: HY-102093