Infection

Methyl isocostate (compound 24）has antibacterial activity that can be isolated from Globba schomburgkii.

MERS-CoV-IN-4 is an orally active antiviral inhibitor targeting the MERS-CoV spike (S) protein, with an IC₅₀ of 0.009 μM in Huh-7 cells, and K_d values of 7.72 μM for the full-length S protein and 5.09 μM for S-RBD. MERS-CoV-IN-4 inhibits viral entry, and suppresses MERS-CoV pseudoviruses and live viruses in vitro. MERS-CoV-IN-4 reduces pulmonary viral loads in hDPP4 transgenic mice. MERS-CoV-IN-4 can be used for research on Middle East respiratory syndrome coronavirus infection.

PSI-353661 (GS-558093) is a purine nucleotide NS5B polymerase inhibitor against HCV infection. PSI-353661 shows EC₉₀s of 8 nM and 11 nM for wild type and S282T resistant replicons of HCV. PSI-353661 can produce high concentrations of the active triphosphate in primary human hepatocytes.

LBP-14-NH₂ (TFA) is a lipopolysaccharide (LPS)-binding protein (LBP) inhibitor. LBP-14-NH₂ TFA interacts with LPS (HY-D1056) to form a complex and blocks the interaction between LBP and LPS. LBP-14-NH₂ TFA can be used in studies related to Gram-negative bacterial sepsis.

TDI-014925 (Compound 58) is a SARS-CoV-2 methyltransferase nonstructural protein 14 (NSP14) inhibitor with an IC₅₀ of 0.2 nM. TDI-014925 has an antiviral activity with significant microsomal stability and no CYP inhibitory activity. TDI-014925 can be used for COVID-19 research.

VMPWDEWLTKRKPELP is a chikungunya virus (CHIKV) nsP2 protease inhibitor with a IC₅₀ of 4.6 μM and a K_d of 1.39 μM. VMPWDEWLTKRKPELP can be used for the research of chikungunya fever.

Bacopasaponin C (Standard) is the analytical standard of Bacopasaponin C (HY-N6015). This product is intended for research and analytical applications. Bacopasaponin C is an orally active natural glycoside. Bacopasaponin C can be isolated from Bacopa monniera. Bacopasaponin C inhibits Verapamil (HY-14275)-stimulated P-gp ATPase activity with an IC₅₀ of 57.83 μg/mL. Bacopasaponin C has antitumor activity against sarcomas. Bacopasaponin C has antiparasitic activity against Leishmania donovani.

nNIF peptide is an endogenous polypeptide detectable in human umbilical cords and neonatal blood. nNIF peptide specifically inhibits neutrophil extracellular trap (NETs) formation by neutrophils without interfering with other key immune functions of neutrophils. nNIF peptide can be used in studies related to COVID-19 acute respiratory distress syndrome, polymicrobial sepsis, and neonatal infectious peritonitis.

BTZ-N3 is a potent reversible and noncovalent inhibitor of decaprenylphosphoryl-β-d-ribose 2′ oxidase (DprE1) that shows anti-tuberculosis activity.

Antimalarial agent 23 is an antimalarial benzimidazole with IC₅₀s of 0.08 μM and 0.10 μM for PfNF54 and PfK1, respectively. Antimalarial agent 23 has potent β-hematin inhibition activity. Antimalarial agent 23 does not directly inhibit the conversion of heme to hemozoin.

ZIKV-IN-9 is a ZIKV inhibitor that blocks the early binding of viral particles to the cell surface. ZIKV-IN-9 inhibits ZIKV in various cell models. ZIKV-IN-9 is applicable to research related to Zika virus infection.

(+)-Aureol is a tetracyclic benzopyran-fused decalin-type 9-norspongiane heteroterpenoid. (+)-Aureol exhibits antifungal activity, with an EC₅₀ value of 6.9 μM against Rhizoctonia solani and an EC₅₀ value of 19 μM against Sclerotinia sclerotiorum. (+)-Aureol shows selective inhibitory activity against human tumor cells. (+)-Aureol acts as an anti-influenza agent with activity against influenza A virus. (+)-Aureol can be used in research related to fungal infections, non-small cell lung cancer, colon adenocarcinoma and influenza A virus infections.

PD 116152 is a phenazine Antibiotic with antimicrobial and antitumor activity. PD 116152 possesses cytotoxic activity against L1210 lymphocytic leukemia and human colon adenocarcinoma (HCT-8) cells with IC₅₀ values of 5.2 x 10^-7 M and 7.1 x 10^-7 M, respectively. PD 116152 is promising for research of P388 lymphocytic leukemia.

Oseltamivir-fructosyl exhibits antiviral activity against influenza viruses and has inhibitory effects on various types of bacteria such as streptococcus and serratia marcescens.

DNDI-0690 is a potent orally active analogue of DNDI-VL-2098, exhibiting potent activity against cutaneous leishmaniasis (CL). DNDI-0690 shows potent in vitro activity against CL-causing Leishmania species (EC₅₀ = 0.17 μM against visceral leishmaniasis (VL), and < 5 μM against CL-causing species). DNDI-0690 exerts effects in a mouse model of L. major CL. DNDI-0690 can be used for CL research.

Majoranaquinone exhibits a high antibacterial effect against 4 Staphylococcus, 1 Moraxella, and 1 Enterococcus strains. Majoranaquinone shows substantial efflux pump inhibitory activity in Escherichia coliATCC 25922 strain. Majoranaquinone is found to be an effective biofilm formation inhibitor on E.coli, ATCC 25922 and E. coli K-12 AG100 bacteria.

Insecticidal agent 24 is an orally active pyridylspiroindoline frontrunner. Insecticidal agent 24 has antiplasmodial activity (Pf NF54 IC₅₀: 0.08 μM). Insecticidal agent 24 inhibits hERG activity (IC₅₀: 6.5 μM). Insecticidal agent 24 reduces parasitemia in a humanized immunodeficient NSG mouse Plasmodium falciparum infection model.

AIC-292 is a potent and selective inhibitor of HIV-1 nonnucleoside reverse transcriptase. AIC-292 inhibits wild-type HIV-1 laboratory strains at low nanomolar concentrations. AIC-292 displays potent antiviral in vivo efficacy in a mouse xenograft model. AIC-292 has the potential for the research of HIV-1 infection.

(+)-Sorokinianin is a phytotoxin from an isolate of Bipolaris sorokiniana.

DNA gyrase B-IN-1 (compound 13) is a potent DNA gyrase B inhibitor. DNA gyrase B-IN-1 shows inhibition of P. aeruginosa DNA gyrase B, with an IC₅₀ of 2.2 μM. DNA gyrase B-IN-1 has good binding affinity and stability.