PMEG-DP disodium
PMEG-DP disodium is a potent DNA polymerase inhibitor (IC50=2.5 μM), especially for DNA polymerase α and δ. PMEG-DP disodium acts as an active metabolite of G-9191, which effectively inhibits the growth of papillomavirus (HPV) -infected cell lines. PMEG-DP disodium can be used in the study of HPV-related diseases.
For research use only. We do not sell to patients.
- Formula: C8H12N5Na2O11P3
- Molecular Weight:493.11
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Protocols
- Purity & Documentation
- References
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Help & FAQs
All DNA/RNA Synthesis Isoforms
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Biological Activity
Description
IC50 & Target
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DNA Polymerase |
Chemical Information
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Molecular Weight 493.11
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Formula C8H12N5Na2O11P3
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SMILES
O=C1N=C(NC2=C1N=CN2CCOCP(O)(OP(O)(OP(O[Na])(O[Na])=O)=O)=O)N
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Protocols
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Cell Cytotoxicity Assay
Cytotoxicity assays are usually based on the assessment of cell membrane damage, which can also be indirectly detected by measuring cell viability. Detection methods include MTT assay, CKK-8 assay, LDH assay and ATP assay, etc.
Purity & Documentation
References
[1]. Wolfgang G H I, et al. GS-9191 is a novel topical prodrug of the nucleotide analog 9-(2-phosphonylmethoxyethyl) guanine with antiproliferative activity and possible utility in the treatment of human papillomavirus lesions[J]. Antimicrobial agents and chemotherapy, 2009, 53(7): 2777-2784. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
PMEG-DP disodium Related Classifications
HY-164018A Related Classifications
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