2. Infection

Infection

Infection

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Infection is a pathophysiological process that involves the invasion and colonization of a living organism (host) by disease-causing infectious agents, the reaction of host tissues to these agents and the toxins they produce, and the transmission of infectious agents to other hosts. Common infectious agents include viruses, viroids, prions, bacteria, nematodes, arthropods, and other macroparasites such as tapeworms. Hosts can fight infections using their immune system. Mammals often engage both innate and adaptive immune systems to eliminate infectious agents or inhibit their growth and transmission. When infection occurs, anti-infective drugs can suppress the infection. Several broad types of anti-infective drugs exist, depending on the type of organism targeted; they include antibacterial (antibiotic), antiviral, antifungal and antiparasitic agents.

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-171457
    WR-27653 6042-36-0 98%
    WR-27653 (RC-12) is a derivative of Catechol with good activity against hypnozoites in the gold-standard Plasmodium cynomolgi-rhesus monkey (Macaca mulatta) model. WR-27653 has antimalarial activity.
    WR-27653
  • HY-171574
    3′-Azido-2′,3′-dideoxy-CTP 92562-77-1 98%
    3′-Azido-2′,3′-dideoxy-CTP (AZddCTP) is a cytidine analog containing a 3-azido group. As a chain terminator, 3′-Azido-2′,3′-dideoxy-CTP can be incorporated into the nascent DNA chain by HIV reverse transcriptase. 3′-Azido-2′,3′-dideoxy-CTP terminates DNA synthesis due to the lack of a 3'-hydroxyl group, thereby inhibiting viral replication. 3′-Azido-2′,3′-dideoxy-CTP has IC50 values of 15.6 μM and 160.8 μM for WT HIV and AZTR HIV. 3′-Azido-2′,3′-dideoxy-CTP has antiviral activity.
    3′-Azido-2′,3′-dideoxy-CTP
  • HY-171587
    3′-Deoxy CTP 69383-05-7 98%
    3′-Deoxy CTP is a nucleotide analogue and a mandatory chain terminator. 3′-Deoxy CTP can cause chain termination by lacking the 3′-hydroxyl group, inhibiting the RNA synthesis activity of HCV nonstructural protein (NS5B) polymerase and blocking viral replication. 3′-Deoxy CTP can be used to study the chain termination mechanism of HCV polymerase and the development of antiviral drugs.
    3′-Deoxy CTP
  • HY-171699
    Antibacterial agent 339 126221-77-0 98%
    Antibacterial agent 339 is an antibacterial agent. Antibacterial agent 339 inhibits the growth of Fusarium oxysporum f.sp.cubense Race 4 with a MIC of 50.5 μM. Antibacterial agent 339 shows low toxicity in mice. FLT3-IN-30 can be used for the research of banana wilt.
    Antibacterial agent 339
  • HY-171795
    Isolubimin 60077-68-1 98%
    Isolubimin is a sesquiterpenoid phytoalexin found in Datura stramonium fruits with antibacterial activity. Isolubimin is promising for research of plant disease caused by fungal infections.
    Isolubimin
  • HY-171796
    Bromomonilicin 101023-71-6 98%
    Bromomonilicin is a selective fungal cell membrane inhibitor. Bromomonilicin exerts antifungal activity by disrupting fungal cell membrane integrity. Bromomonilicin is promising for research of plant pathogenic fungal infections (e.g., Monilinia fructicola-induced brown rot) and superficial mycoses (e.g., dermatophyte infections).
    Bromomonilicin
  • HY-171832
    5'-Amino-5'-deoxyuridine 34718-92-8
    5'-Amino-5'-deoxyuridine is a nucleoside analog that can be used in nucleic acid synthesis.
    5'-Amino-5'-deoxyuridine
  • HY-171956
    Carmaphycin-17 2143080-91-3 98%
    Carmaphycin-17 (CP-17) is a selective 20S proteasome inhibitor with an EC50 of 217 ?nM. Carmaphycin-17 has potent antimicrobial activity against Trichomonas vaginalis. Carmaphycin-17 overcomes Metronidazole (HY-B0318) resistance and significantly reduces parasite burden upon topical treatment without any apparent adverse effects in vaginal trichomonad infection mice model. Carmaphycin-17 can be used for sexually transmitted disease like trichomoniasis research.
    Carmaphycin-17
  • HY-171983
    RSV-IN-13 2724259-07-6 98%
    RSV-IN-13 (compound 24) is a selective RSV fusion protein inhibitor with antiviral activity. RSV-IN-13 has an EC50 of 444.2 nM against RSV A2 strain and a CC90 of 23.7 μM in HepG2 cells. RSV-IN-13 can block the virus from entering host cells. RSV-IN-13 can be used to study RSV infection.
    RSV-IN-13
  • HY-172006
    Probetaenone I 115473-44-4 98%
    Probetaenone I is an intermediate in the biosynthesis of the phytotoxin betaenone B from P. betae.
    Probetaenone I
  • HY-172007
    Acremine F 863480-61-9 98%
    Acremine F is a fungal metabolite that has been found in Acremonium.
    Acremine F
  • HY-172023
    apo-Enterobactin 30414-16-5 98%
    apo-Enterobactin is a derivative of Enterobactin (HY-128525). Enterobactin is a bacterial siderophore that promotes iron absorption.
    apo-Enterobactin
  • HY-172027
    Remdesivir methylpropyl ester analog 3047145-80-9 98%
    Remdesivir methylpropyl ester analog (GS-5734 methylpropyl ester analog) is a derivative of Remdesivir (HY-104077). Remdesivir is a nucleoside analogue with effective antiviral activity.
    Remdesivir methylpropyl ester analog
  • HY-172109
    DNA Gyrase-IN-15 98%
    DNA Gyrase-IN-15 (Compound 11) is an antimicrobial agent and inhibitor of DHPS and DNA gyrase, with IC50s of 1.73 and 0.07 µM, respectively. DNA Gyrase-IN-15 shows antimicrobial activity against Enterococcus faecalis (MIC of 15.62 µg/mL), Acinetobacter baumannii, Enterobacter species (MIC of 7.81 µg/mL), Pseudomonas aeruginosa, Klebsiella pneumoniae and Staphylococcus aureus. DNA Gyrase-IN-15 also shows antibiofilm activity against Enterococcus faecalis.
    DNA Gyrase-IN-15
  • HY-172207
    POPTc80-IN-1 98%
    POPTc80-IN-1 (Compound LC-45) is a competitive inhibitor for prolyl oligopeptidase of Trypanosoma cruzi POPTc80 with an IC50 of 0.23 μM and a Ki of 0.054 μM. POPTc80-IN-1 inhibits the invasion of T. cruzi into host cell with an IC50 of 46.71 μM.
    POPTc80-IN-1
  • HY-172216
    EV-A71-IN-3 98%
    EV-A71-IN-3 (Compound IRE-03-3) is the inhibitor for Enterovirus A71 EV-A71 that targets internal ribosomal entry site (IRES) of EV-A71, inhibits IRES-mediated translation, and inhibits the viral proliferation with an EC50 of 11.96 μM.
    EV-A71-IN-3
  • HY-172223
    3-Deazaguanosine 56039-11-3 98%
    3-Deazaguanosine (C3Guo) has potent antiviral activity against SARS-CoV-2 (EC50: 1.14 μM, CC50: >200 μM for Vero E6 cells). 3-Deazaguanosine prevents COVID-19 pneumonia.
    3-Deazaguanosine
  • HY-172229
    NBTI 5463 1227303-03-8 98%
    NBTI 5463 is a bacterial type II topoisomerases (topoisomerase II) inhibitor with antibacterial activity. NBTI 5463 inhibits GyrA and TopoIV in Pseudomonas aeruginosa and Escherichia coli. NBTI 5463 binds to topoisomerase II to prevent DNA cleavage and religation, inhibiting bacterial DNA replication and transcription. NBTI 5463 is promising for research of Gram-negative bacterial infection.
    NBTI 5463
  • HY-172230
    Anti-infective agent 10 1132936-19-6 98%
    Anti-infective agent 10 (Compound Example 30) is a ns5b polymerase inhibitor that can be used as an anti-HCV agent.
    Anti-infective agent 10
  • HY-172250
    8-Hydroxyerythromycin A 51433-35-3 98%
    8-Hydroxyerythromycin is a semi-synthetic antibiotic with an antibacterial activity.
    8-Hydroxyerythromycin A
Cat. No. Product Name / Synonyms Application Reactivity