NBTI 5463
NBTI 5463 is a bacterial type II topoisomerases (topoisomerase II) inhibitor with antibacterial activity. NBTI 5463 inhibits GyrA and TopoIV in Pseudomonas aeruginosa and Escherichia coli. NBTI 5463 binds to topoisomerase II to prevent DNA cleavage and religation, inhibiting bacterial DNA replication and transcription. NBTI 5463 is promising for research of Gram-negative bacterial infection.
For research use only. We do not sell to patients.
- CAS No.: 1227303-03-8
- Formula: C25H30N6O4
- Molecular Weight:478.54
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
All Topoisomerase Isoforms
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Biological Activity
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Topoisomerase II |
Chemical Information
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CAS No. 1227303-03-8
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Molecular Weight 478.54
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Formula C25H30N6O4
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SMILES
N[C@H]([C@@]1([H])CC[C@@H](CC1)NCC2=CC=C(OCC(N3)=O)C3=N2)CN4C5=CC(OC)=CN=C5C=CC4=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)