3′-Azido-2′,3′-dideoxy-CTP  (Synonyms: AZddCTP)

3′-Azido-2′,3′-dideoxy-CTP (AZddCTP) is a cytidine analog containing a 3-azido group. As a chain terminator, 3′-Azido-2′,3′-dideoxy-CTP can be incorporated into the nascent DNA chain by HIV reverse transcriptase. 3′-Azido-2′,3′-dideoxy-CTP terminates DNA synthesis due to the lack of a 3'-hydroxyl group, thereby inhibiting viral replication. 3′-Azido-2′,3′-dideoxy-CTP has IC₅₀ values of 15.6 μM and 160.8 μM for WT HIV and AZT^R HIV. 3′-Azido-2′,3′-dideoxy-CTP has antiviral activity^[1].

492.17

C₉H₁₅N₆O₁₂P₃

92562-77-1

O=P(OP(OP(O)(O)=O)(O)=O)(O)OC[C@H]1O[C@@H](N2C(N=C(N)C=C2)=O)C[C@@H]1N=[N+]=[N-]

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Sluis-Cremer N, et al. The 3'-azido group is not the primary determinant of 3'-azido-3'-deoxythymidine (AZT) responsible for the excision phenotype of AZT-resistant HIV-1. J Biol Chem. 2005 Aug 12;280(32):29047-52.  [Content Brief]