2. Infection

Infection

Infection

Related Products

PDF 70.44 MB

Infection is a pathophysiological process that involves the invasion and colonization of a living organism (host) by disease-causing infectious agents, the reaction of host tissues to these agents and the toxins they produce, and the transmission of infectious agents to other hosts. Common infectious agents include viruses, viroids, prions, bacteria, nematodes, arthropods, and other macroparasites such as tapeworms. Hosts can fight infections using their immune system. Mammals often engage both innate and adaptive immune systems to eliminate infectious agents or inhibit their growth and transmission. When infection occurs, anti-infective drugs can suppress the infection. Several broad types of anti-infective drugs exist, depending on the type of organism targeted; they include antibacterial (antibiotic), antiviral, antifungal and antiparasitic agents.

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-173514
    SARS-CoV-2 Mpro-IN-42 98%
    SARS-CoV-2 Mpro-IN-42 (compound C5) is a potent SARS-CoV-2 Mpro inhibitor with an IC50 of 33.6 nM. SARS-CoV-2 Mpro-IN-42 can be used in the study of SARS-CoV-2.
    SARS-CoV-2 Mpro-IN-42
  • HY-173528
    Antimicrobial agent-40 98%
    Antimicrobial agent-40 (Compound 5a) has antimicrobial activity against fungi, Gram-negative and Gram-positive bacteria. Antimicrobial agent-40 has good cytotoxicity against MCF-7 cells (IC50: 33.52 μM) and exhibits anticancer activity.
    Antimicrobial agent-40
  • HY-173554
    MPXV I7L protease-IN-1
    MPXV I7L protease-IN-1 (compound 11) is a Monkeypox virus I7L protease inhibitor with the IC50 of 69 nM.
    MPXV I7L protease-IN-1
  • HY-173567
    WJM664
    WJM664 is a potent Plasmodium falciparum PfATP4 inhibitor. WJM664 shows strong activity against malaria parasites. WJM664 blocks gamete development and transmission to mosquitoes by inhibiting PfATP4-mediated Na+-dependent ATPase activity, and acts on multiple stages of the malaria parasite life cycle.
    WJM664
  • HY-173575
    SARS-CoV-2 3CLpro-IN-31
    SARS-CoV-2 3CLpro-IN-31 (Compound 13c) is a potent SARS-CoV-2 3CL protease (3CLpro) inhibitor of with an IC50 value of 37.33 nM. SARS-CoV-2 3CLpro-IN-31 blocks viral polyprotein cleavage and inhibits SARS-CoV-2 replication. SARS-CoV-2 3CLpro-IN-31 is promising for research of SARS-CoV-2 infection.
    SARS-CoV-2 3CLpro-IN-31
  • HY-173583
    4'-Acetyl chrysomycin C 2827194-69-2
    4'-Acetyl chrysomycin C is a 4’-acetylated analog of Chrysomycin. Chrysomycin is a classic antibiotic.
    4'-Acetyl chrysomycin C
  • HY-173586
    N-Dodecanoyl-L-homoserine lactone-3-hydrazone-biotin
    N-Dodecanoyl-L-homoserine lactone-3-hydrazone-biotin (N-Dodecanoyl-L-hsl-3-hydrazone-biotin) is a biotin-tagged bacterial quorum sensing probe that links the quorum sensing signaling molecule AHL (acyl-homoserine lactone) to biotin via a hydrazone bond.
    N-Dodecanoyl-L-homoserine lactone-3-hydrazone-biotin
  • HY-17358R
    Loteprednol Etabonate (Standard) 82034-46-6 98%
    Loteprednol Etabonate (Standard) is the analytical standard of Loteprednol Etabonate. This product is intended for research and analytical applications. Loteprednol etabonate (LE) is an orally active "soft" steroid belonging to a unique class of glucocorticoids. Loteprednol etabonate (LE) exhibits anti-inflammatory activity and has been used in optometry and ophthalmology.
    Loteprednol Etabonate (Standard)
  • HY-173595
    ODE-(S)-HPMPA formate 3032979-17-9 98%
    ODE-(S)-HPMPA formate is an antiviral compound with strong inhibitory activity against poxviruses and adenoviruses. ODE-(S)-HPMPA formate activates TNF-α secretion.
    ODE-(S)-HPMPA formate
  • HY-173598
    T3SS-1-IN-1 930993-54-7 98%
    T3SS-1-IN-1 (Compound C26) is a T3SS-1 inhibitor. T3SS-1-IN-1 inhibits the secretion of SipA and the activity of HilD (IC50 values are 29.2 and 16.9 μM, respectively). T3SS-1-IN-1 can be used for the study of anti-virulence of Salmonella.
    T3SS-1-IN-1
  • HY-173617
    GDI-5755 849616-57-5 98%
    GDI-5755 (SAM002706100), an antibacterial agent by inhibiting ClpP1P2, inhibits the growth of Mtb and M. bovis BCG, the model organism of mycobacteria. GDI-5755 can be used in the research for tuberculosis (TB).
    GDI-5755
  • HY-173620
    Carbonic anhydrase inhibitor 31 98%
    Carbonic anhydrase inhibitor 31 (Compound 3F4) is a mtCA2 inhibitor (Ki: 5.2 nM). Carbonic anhydrase inhibitor 31 can be used in the research of anti-tuberculosis.
    Carbonic anhydrase inhibitor 31
  • HY-17367R
    Atazanavir (Standard) 198904-31-3 98%
    Atazanavir (Standard) is the analytical standard of Atazanavir. This product is intended for research and analytical applications. Atazanavir (BMS-232632) is a highly selective and orally active HIV-1 protease inhibitor . Atazanavir is a substrate and inhibitor of CYP3A4, and an inhibitor of P-glycoprotein (P-gp). Atazanavir is also a SARS-CoV 3CLpro inhibitor with an IC50 of 3.49 μM. Atazanavir inhibits cardiac fibrosis, hyperlipidemia and induces malignant glioma death.
    Atazanavir (Standard)
  • HY-17373A
    Posaconazole hydrate 1198769-38-8 98%
    Posaconazole hydrate is a broad-spectrum, second generation, triazole compound with antifungal activity.
    Posaconazole hydrate
  • HY-17374R
    Benfotiamine (Standard) 22457-89-2 98%
    Benfotiamine (Standard) is the analytical standard of Benfotiamine. This product is intended for research and analytical applications. Benfotiamine (S-Benzoylthiamine O-monophosphate) is a vitamin B1 derivative that exhihibits potent antioxidative and anti-inflammatory activity. Benfotiamine can be used for the research of various secondary diabetic complications. Benfotiamine also can be used in infectious diseases such as HIV and COVID-19.
    Benfotiamine (Standard)
  • HY-17381R
    Idarubicin hydrochloride (Standard) 57852-57-0
    Idarubicin (hydrochloride) (Standard) is the analytical standard of Idarubicin (hydrochloride). This product is intended for research and analytical applications. Idarubicin hydrochloride is an anthracycline antileukemic agent. It inhibits the topoisomerase II interfering with the replication of DNA and RNA transcription. Idarubicin hydrochloride inhibits the growth of bacteria and yeasts.
    Idarubicin hydrochloride (Standard)
  • HY-17395R
    Terbinafine hydrochloride (Standard) 78628-80-5 98%
    Terbinafine hydrochloride (Standard) is the analytical standard of Terbinafine hydrochloride. This product is intended for research and analytical applications. Terbinafine hydrochloride (TDT 067 hydrochloride) is an orally active and potent antifungal agent. Terbinafine hydrochloride is a potent non-competitive inhibitor of squalene epoxidase from Candida, with a Ki of 30 nM. Terbinafine hydrochloride also shows antibacterial activity against certain Gram-positive and Gram-negative bacteria. Terbinafine hydrochloride is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
    Terbinafine hydrochloride (Standard)
  • HY-17403R
    Manidipine dihydrochloride (Standard) 89226-75-5 98%
    Manidipine (dihydrochloride) (Standard) is the analytical standard of Manidipine (dihydrochloride). This product is intended for research and analytical applications. Manidipine dihydrochloride is a third-generation, lipophilic, orally active and highly vasoselective calcium channel antagonist (IC50 = 2.6 nM in guinea-pig ventricular cells) and acts as an antihypertensive agent. Manidipine effectively reduces blood pressure as well as improving insulin sensitivity, renal protection, and antiatherosclerotic activity. Manidipine also exerts anti-inflammatory activity mediated by NF-κB and antiviral activity against many flavivirus and negative-strand RNA viruses through the inhibition of calcium channel. Manidipine is widely applied to research of cardiovascular, metabolic disease and infection.
    Manidipine dihydrochloride (Standard)
  • HY-174125
    4-(Cyclohexyldisulfaneyl) pyridine 128999-51-9
    4-(Cyclohexyldisulfaneyl)pyridine is a Type III secretion system (T3SS) inhibitor that suppresses the promoter activity of T3SS-related genes (hrpA and hrpL) in Erwinia amylovora CFBP1430. 4-(Cyclohexyldisulfaneyl) pyridine can be utilized in study on fire blight disease.
    4-(Cyclohexyldisulfaneyl) pyridine
  • HY-174130
    PI4Kβ/PKG-IN-1
    PI4Kβ/PKG-IN-1 (Compound 19) is an orally active dual inhibitor targeting Plasmodium phosphatidylinositol 4-kinase beta (PI4Kβ) and cGMP-dependent protein kinase (PKG). PI4Kβ/PKG-IN-1 exhibits potent antiplasmodial activity. PI4Kβ/PKG-IN-1 is promising for research of malaria.
    PI4Kβ/PKG-IN-1
Cat. No. Product Name / Synonyms Application Reactivity