Manidipine dihydrochloride (Standard)
Manidipine (dihydrochloride) (Standard) is the analytical standard of Manidipine (dihydrochloride). This product is intended for research and analytical applications. Manidipine dihydrochloride is a third-generation, lipophilic, orally active and highly vasoselective calcium channel antagonist (IC50 = 2.6 nM in guinea-pig ventricular cells) and acts as an antihypertensive agent. Manidipine effectively reduces blood pressure as well as improving insulin sensitivity, renal protection, and antiatherosclerotic activity. Manidipine also exerts anti-inflammatory activity mediated by NF-κB and antiviral activity against many flavivirus and negative-strand RNA viruses through the inhibition of calcium channel. Manidipine is widely applied to research of cardiovascular, metabolic disease and infection.
For research use only. We do not sell to patients.
- Purity: 98%
- CAS No.: 89226-75-5
- Formula: C35H40Cl2N4O6
- Molecular Weight:683.62
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Product Information
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Chemical Information
- Purity & Documentation
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Help & FAQs
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Product Information
The compound is the grade of analytical standard, which is the reference standard supplied assay. It is commonly used in qualitative, quantitative and methodological research experiments in HPLC, GC and MS.
Chemical Information
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CAS No. 89226-75-5
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Molecular Weight 683.62
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Formula C35H40Cl2N4O6
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SMILES
O=C(C1=C(C)NC(C)=C(C(OC)=O)C1C2=CC=CC([N+]([O-])=O)=C2)OCCN3CCN(C(C4=CC=CC=C4)C5=CC=CC=C5)CC3.[H]Cl.[H]Cl
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Synonyms
CV-4093 (Standard)
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
[1]. Roca-Cusachs A, et al. Antihypertensive effect of manidipine. Drugs. Drugs. 2005，65，11-19. [Content Brief]
[2]. Cavalieri L,, et al. Metabolic effects of manidipine. Am J Cardiovasc Drugs. 2009，9，3. [Content Brief]
[3]. Franco Bernini, et al. Manidipine reduces pro-inflammatory cytokines secretion in human endothelial cells and macrophages. Pharmacol Res. 2010，62，3. [Content Brief]
[4]. Urata S, et al. Calcium Influx Regulates the Replication of Several Negative-Strand RNA Viruses Including Severe Fever with Thrombocytopenia Syndrome Virus. J Virol. 2023，97，3. [Content Brief]
[5]. Wang S, et al. Screening of FDA-Approved Drugs for Inhibitors of Japanese Encephalitis Virus Infection. J Virol. 2017，91，21. [Content Brief]
[6]. Tohse N, et al. Voltage-dependent modulation of L-type Ca2+ current by manidipine in guinea-pig heart cells. Eur J Pharmacol. 1993，249(2):231-3. [Content Brief]
[7]. Yoshiyama M, et al. Effect of manidipine hydrochloride, a calcium antagonist, on isoproterenol-induced left ventricular hypertrophy. Pharmacol Res. 2010Jpn Circ J. 1998，62(1):47-52. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Manidipine dihydrochloride (Standard) Related Classifications
HY-17403R Related Classifications
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- Manidipine dihydrochloride (Standard)
- 89226-75-5
- CV-4093 (Standard)
- Calcium Channel
- NF-κB
- Reference Standards
- Lipophilic
- vasoselective
- calcium channel antagonist
- antihypertensive
- anti-inflammatory
- flavivirus
- negative-strand RNA viruses
- cardiovascular
- metabolic disease
- IFNAR2/2 mice
- BALB/c mice
- Inhibitor
- inhibitor
- inhibit