1. Membrane Transporter/Ion Channel
    Neuronal Signaling
    Autophagy
  2. Calcium Channel
    Autophagy
  3. Felodipine

Felodipine 

Cat. No.: HY-B0309 Purity: 98.93%
Handling Instructions

Felodipine, a dihydropyridine, is a potent, vasoselective calcium channel antagonist. Felodipine lowers blood pressure (BP) by selective action on vascular smooth muscle, especially in the resistance vessels. Felodipine, an anti-hypertensive agent, induces autophagy. Felodipine can cross the blood-brain barrier.

For research use only. We do not sell to patients.

Felodipine Chemical Structure

Felodipine Chemical Structure

CAS No. : 72509-76-3

Size Price Stock Quantity
Free Sample (0.5-1 mg)   Apply Now  
Solution
10 mM * 1 mL in DMSO USD 94 In-stock
Estimated Time of Arrival: December 31
Solid + Solvent
10 mM * 1 mL
ready for reconstitution
USD 94 In-stock
Estimated Time of Arrival: December 31
Solid
10 mg USD 85 In-stock
Estimated Time of Arrival: December 31
50 mg USD 209 In-stock
Estimated Time of Arrival: December 31
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Customer Review

Based on 1 publication(s) in Google Scholar

Other Forms of Felodipine:

Top Publications Citing Use of Products

1 Publications Citing Use of MCE Felodipine

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

Felodipine, a dihydropyridine, is a potent, vasoselective calcium channel antagonist. Felodipine lowers blood pressure (BP) by selective action on vascular smooth muscle, especially in the resistance vessels. Felodipine, an anti-hypertensive agent, induces autophagy. Felodipine can cross the blood-brain barrier[1][2][3].

In Vitro

Felodipine, a dihydropyridine calcium antagonist, is the most potent in relaxing porcine coronary arteries (IC50=0.15 nM)[1].
Felodipine, an L-type calcium channel blocker, induces autophagy and clears diverse aggregate-prone, neurodegenerative disease-associated proteins [2].
Felodipine blocks the muscarinic receptor-mediated (carbachol) Ca2+-dependent contraction of guinea pig ileum longitudinal smooth muscle (GPILSM) with an IC50 of 1.45 nM[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Clinical Trial
Molecular Weight

384.25

Formula

C₁₈H₁₉Cl₂NO₄

CAS No.
Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (260.25 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.6025 mL 13.0124 mL 26.0247 mL
5 mM 0.5205 mL 2.6025 mL 5.2049 mL
10 mM 0.2602 mL 1.3012 mL 2.6025 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (6.51 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (6.51 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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Product Name:
Felodipine
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HY-B0309
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