1. Membrane Transporter/Ion Channel
    Neuronal Signaling
    Autophagy
  2. Calcium Channel
    Autophagy
  3. Felodipine

Felodipine 

Cat. No.: HY-B0309 Purity: 99.75%
Handling Instructions

Felodipine is a long-acting 1,4-dihydropyridine calcium channel blocker.

For research use only. We do not sell to patients.

Felodipine Chemical Structure

Felodipine Chemical Structure

CAS No. : 72509-76-3

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Free Sample (0.5-1 mg)   Apply now  
10 mM * 1 mL in DMSO USD 94 In-stock
Estimated Time of Arrival: December 31
10 mg USD 85 In-stock
Estimated Time of Arrival: December 31
50 mg USD 209 In-stock
Estimated Time of Arrival: December 31
100 mg   Get quote  
200 mg   Get quote  

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Based on 1 publication(s) in Google Scholar

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Description

Felodipine is a long-acting 1,4-dihydropyridine calcium channel blocker. Target: Calcium Channel Felodipine is a long-acting 1,4-dihydropyridine calcium channel blocker (CCB)b. It acts primarily on vascular smooth muscle cells by stabilizing voltage-gated L-type calcium channels in their inactive conformation. Felodipine significantly relaxes KCl-contracted porcine coronary segments by blocking the Ca2+ channels, displaying ~50 times more potent than nifedipine (IC50 of ~8 nM) and ~430 times than verapamil (IC50 of ~65 nM) [1]. Felodipine significantly induces the transcription and secretion of IL-6 and IL-8 with ED50 values of 5.8 nM and 5.3 nM in primary human VSMC and lung fibroblasts, respectively, while propranolol or furosemide fails to affect the expression of the two IL genes [2]. Felodipine blocks the muscarinic receptor-mediated (carbachol) Ca2+-dependent contraction of guinea pig ileum longitudinal smooth muscle (GPILSM) with an IC50 of 1.45 nM [3].

Clinical Trial
Molecular Weight

384.25

Formula

C₁₈H₁₉Cl₂NO₄

CAS No.

72509-76-3

SMILES

O=C(C1=C(C)NC(C)=C(C(OC)=O)C1C2=CC=CC(Cl)=C2Cl)OCC

Shipping

Room temperature in continental US; may vary elsewhere

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (260.25 mM; Need ultrasonic)

H2O : < 0.1 mg/mL (insoluble)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.6025 mL 13.0124 mL 26.0247 mL
5 mM 0.5205 mL 2.6025 mL 5.2049 mL
10 mM 0.2602 mL 1.3012 mL 2.6025 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (6.51 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (6.51 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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Felodipine
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HY-B0309
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