Felodipine-d3
Based on 1 Customer Validation
Felodipine-d3 is the deuterium labeled Felodipine. Felodipine, a dihydropyridine, is a potent, vasoselective calcium channel antagonist. Felodipine lowers blood pressure (BP) by selective action on vascular smooth muscle, especially in the resistance vessels. Felodipine, an anti-hypertensive agent, induces autophagy. Felodipine can cross the blood-brain barrier.
For research use only. We do not sell to patients.
- Purity: 99.78%
- CAS No.: 1219795-30-8
- Formula: C18H16D3Cl2NO4
- Molecular Weight:387.27
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
All Calcium Channel Isoforms
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Biological Activity
Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
1. This compound can be used as a tracer
2. This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
Chemical Information
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CAS No. 1219795-30-8
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Unlabeled Cas 72509-76-3
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Appearance Solid
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Molecular Weight 387.27
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Formula C18H16D3Cl2NO4
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Color White to off-white
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SMILES
CCOC(C1=C(C)NC(C)=C(C(OC)=O)C1C2=C(C(Cl)=C([2H])C([2H])=C2[2H])Cl)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
DMSO : 100 mg/mL (258.22 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (277 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Handling Instructions (2659 KB)
References
[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [Content Brief]
[2]. Johnson JD, et al. Calcium and calmodulin antagonists binding to calmodulin and relaxation of coronary segments. J Pharmacol Exp Ther. 1983;226(2):330-334. [Content Brief]
[3]. Siddiqi FH, et al. Felodipine induces autophagy in mouse brains with pharmacokinetics amenable to repurposing [published correction appears in Nat Commun. 2019 Jun 4;10(1):2530]. Nat Commun. 2019;10(1):1817. Published 2019 Apr 18. [Content Brief]
[4]. Yiu, S. and E.E. Knaus, Synthesis, biological evaluation, calcium channel antagonist activity, and anticonvulsant activity of felodipine coupled to a dihydropyridine-pyridinium salt redox chemical delivery system. J Med Chem, 1996. 39(23): p. 4576-82. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
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| DMSO | 1 mM | 2.5822 mL | 12.9109 mL | 25.8218 mL | 64.5544 mL |
| 5 mM | 0.5164 mL | 2.5822 mL | 5.1644 mL | 12.9109 mL | |
| 10 mM | 0.2582 mL | 1.2911 mL | 2.5822 mL | 6.4554 mL | |
| 15 mM | 0.1721 mL | 0.8607 mL | 1.7215 mL | 4.3036 mL | |
| 20 mM | 0.1291 mL | 0.6455 mL | 1.2911 mL | 3.2277 mL | |
| 25 mM | 0.1033 mL | 0.5164 mL | 1.0329 mL | 2.5822 mL | |
| 30 mM | 0.0861 mL | 0.4304 mL | 0.8607 mL | 2.1518 mL | |
| 40 mM | 0.0646 mL | 0.3228 mL | 0.6455 mL | 1.6139 mL | |
| 50 mM | 0.0516 mL | 0.2582 mL | 0.5164 mL | 1.2911 mL | |
| 60 mM | 0.0430 mL | 0.2152 mL | 0.4304 mL | 1.0759 mL | |
| 80 mM | 0.0323 mL | 0.1614 mL | 0.3228 mL | 0.8069 mL | |
| 100 mM | 0.0258 mL | 0.1291 mL | 0.2582 mL | 0.6455 mL |
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