1219795-30-8
Chemical Structure
Felodipine-d3
- No. CAS: 1219795-30-8
- Formula:C18H16D3Cl2NO4
- Molecular Weight:387.27
IUPAC Name: 3-ethyl 5-methyl 4-(2,3-dichlorophenyl-4,5,6-d3)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate
InChIKey: RZTAMFZIAATZDJ-AYBVGXBASA-N
SMILES: CCOC(C1=C(C)NC(C)=C(C(OC)=O)C1C2=C(C(Cl)=C([2H])C([2H])=C2[2H])Cl)=O
Biological Activity: Felodipine-d3 is the deuterium labeled Felodipine. Felodipine, a dihydropyridine, is a potent, vasoselective calcium channel antagonist. Felodipine lowers blood pressure (BP) by selective action on vascular smooth muscle, especially in the resistance vessels. Felodipine, an anti-hypertensive agent, induces autophagy. Felodipine can cross the blood-brain barrier[1][2][3].
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Felodipine-d3 | 99.78% | Felodipine-d3 is the deuterium labeled Felodipine. Felodipine, a dihydropyridine, is a potent, vasoselective calcium channel antagonist. Felodipine lowers blood pressure (BP) by selective action on vascular smooth muscle, especially in the resistance vessels. Felodipine, an anti-hypertensive agent, induces autophagy. Felodipine can cross the blood-brain barrier. | ||||||||||||||||||||
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Felodipine (Standard) | 99.73% | Felodipine (Standard) is the analytical standard of Felodipine. This product is intended for research and analytical applications. Felodipine, a dihydropyridine, is a potent, vasoselective calcium channel antagonist. Felodipine lowers blood pressure (BP) by selective action on vascular smooth muscle, especially in the resistance vessels. Felodipine, an anti-hypertensive agent, induces autophagy. Felodipine can cross the blood-brain barrier. | ||||||||||||||||||||
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Felodipine-13C4,d3 | Felodipine-13C4,d3 is 13C labeled Felodipine. | |||||||||||||||||||||
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Felodipine-d5 | Felodipine-d5 is deuterium labeled Felodipine. Felodipine, a dihydropyridine, is a potent, vasoselective calcium channel antagonist. Felodipine lowers blood pressure (BP) by selective action on vascular smooth muscle, especially in the resistance vessels. Felodipine, an anti-hypertensive agent, induces autophagy. Felodipine can cross the blood-brain barrier. | |||||||||||||||||||||
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rac Felodipine-(Methoxy-d3) | rac Felodipine-(Methoxy-d3) is the deuterium labeled rac Felodipine-(Methoxy). | |||||||||||||||||||||
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Felodipine | 99.83% | Felodipine, a dihydropyridine, is a potent, vasoselective calcium channel antagonist. Felodipine lowers blood pressure (BP) by selective action on vascular smooth muscle, especially in the resistance vessels. Felodipine, an anti-hypertensive agent, induces autophagy. Felodipine can cross the blood-brain barrier. | ||||||||||||||||||||
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References
- [1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [Content Brief]
- [2]. Johnson JD, et al. Calcium and calmodulin antagonists binding to calmodulin and relaxation of coronary segments. J Pharmacol Exp Ther. 1983;226(2):330-334. [Content Brief]
- [3]. Siddiqi FH, et al. Felodipine induces autophagy in mouse brains with pharmacokinetics amenable to repurposing [published correction appears in Nat Commun. 2019 Jun 4;10(1):2530]. Nat Commun. 2019;10(1):1817. Published 2019 Apr 18. [Content Brief]
