(S)-(-)-Felodipine
(S)-(-)-Felodipine is a S-enantiomer of Felodipine. (S)-(-)-Felodipine is an antihypertensive agent. Felodipine is a 1,4-dihydropyridine derivative and a vasoselective calcium antagonist. Felodipine can prevent the activation of the vascular effector cells and interfere with the contractile process in vitro. Felodipine lowers mean arterial blood pressure by 20% in dog model. (S)-(-)-Felodipine shows high metabolic rate in rat and dog liver microsomes.
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- CAS No.: 105618-03-9
- Formule: C18H19Cl2NO4
- Masse moléculaire:384.25
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
- Pureté et documentation
- Références
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Activité biologique
Description
Cellular Effect
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| Caco-2 | Inhibition |
51.18 %
Compound: FELODIPINE
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Antiviral activity determined as inhibition of SARS-CoV-2 induced cytotoxicity of Caco-2 cells at 10 uM after 48 hours by high content imaging
Antiviral activity determined as inhibition of SARS-CoV-2 induced cytotoxicity of Caco-2 cells at 10 uM after 48 hours by high content imaging
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10.21203/rs.3.rs-23951/v1 |
Chemical Information
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CAS No. 105618-03-9
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Masse moléculaire 384.25
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Formule C18H19Cl2NO4
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SMILES
CCOC(C1=C(C)NC(C)=C(C(OC)=O)[C@@H]1C2=C(C(Cl)=CC=C2)Cl)=O
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
[1]. Eriksson, U. G., et al., (1991). Stereoselective metabolism of felodipine in liver microsomes from rat, dog, and human. Drug metabolism and disposition: the biological fate of chemicals, 19(5), 889-894. [Content Brief]
[2]. Ljung, B. Vascular Selectivity of Felodipine. Drugs 29 (Suppl 2), 46-58 (1985).
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
(S)-(-)-Felodipine Related Classifications
HY-W700354 Related Classifications
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