2. Inflammation/Immunology

Inflammation/Immunology

Inflammation/Immunology

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The diseases caused by disorders of the immune system fall into two broad categories: immunodeficiency and autoimmunity. Immunotherapy is also often used in the immunosuppressed (such as HIV patients) and people suffering from other immune deficiencies or autoimmune diseases. This includes regulating factors such as IL-2, IL-10, IFN-α. Infection with HIV is characterized not only by development of profound immunodeficiency but also by sustained inflammation and immune activation. Chronic inflammation as a critical driver of immune dysfunction, premature appearance of aging-related diseases, and immune deficiency.

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-N6020R
    (-)-Butin (Standard) 492-14-8 99.84%
    (-)-Butin (Standard) is the analytical standard of (-)-Butin (HY-N6020). This product is intended for research and analytical applications. (-)-Butin is a enantiomer of Butin (HY-N6020B). Butin is a major biologically active flavonoid isolated from the heartwood of Dalbergia odorifera, with strong antioxidant, antiplatelet and anti-inflammatory activities.
    (-)-Butin (Standard)
  • HY-N6652R
    1-beta-D-Arabinofuranosyluracil (Standard) 3083-77-0 99.91%
    1-beta-D-Arabinofuranosyluracil (Standard) is the analytical standard of 1-beta-D-Arabinofuranosyluracil. This product is intended for research and analytical applications. 1-beta-D-Arabinofuranosyluracil (Uracil 1-β-D-arabinofuranoside) isolated from the Caribbean sponge Tectitethya crypta, is a methoxyadenosine derivative. 1-beta-D-Arabinofuranosyluracil has demonstrated a diverse bioactivity profile including anti-inflammatory activity, analgesic and vasodilation properties. 1-beta-D-Arabinofuranosyluracil reduces a proliferation of mouse lymphoma cells.
    1-beta-D-Arabinofuranosyluracil (Standard)
  • HY-N6973R
    Boldine (Standard) 476-70-0 99.83%
    Boldine (Standard) is the analytical standard of Boldine. This product is intended for research and analytical applications. Boldine is an aporphine isoquinoline alkaloid extracted from the root of Litsea cubeba and also possesses these properties, including antioxidant, anti-inflammatory and cytoprotective effects. Boldine suppresses osteoclastogenesis, improves bone destruction by down-regulating the OPG/RANKL/RANK signal pathway and may be a potential therapeutic agent for rheumatoid arthritis.
    Boldine (Standard)
  • HY-N7148R
    γ-Tocopherol (Standard) 54-28-4 99.32%
    γ-Tocopherol (Standard) is the analytical standard of γ-Tocopherol. This product is intended for research and analytical applications. γ-Tocopherol (D-γ-Tocopherol) is a potent cyclooxygenase (COX) inhibitor. γ-Tocopherol is a naturally occurring form of Vitamin E in many plant seeds, such as corn oil and soybeans. γ-Tocopherol possesses antiinflammatory properties and anti-cancer activity.
    γ-Tocopherol (Standard)
  • HY-N8016R
    Nonanal (Standard) 124-19-6 99.31%
    Nonanal (Standard) is the analytical standard of Nonanal. This product is intended for research and analytical applications. Nonanal is a saturated fatty aldehyde with antidiarrhoeal activity.
    Nonanal (Standard)
  • HY-NP0195
    Sheep immunoglobulin G
    Sheep Immunoglobulin G (Sheep IgG) is a sheep serum immunoglobulin that can be used in immunolabeling and coating protein in a variety of immunoassays including ELISA.
    Sheep immunoglobulin G
  • HY-NP0200
    Dog Immunoglobulin G
    Dog Immunoglobulin G (Dog IgG) is a dog serum immunoglobulin that can be used in immunolabeling and coating protein in a variety of immunoassays including ELISA.
    Dog Immunoglobulin G
  • HY-NP083A
    Wisteria Floribunda Lectin (Biotin)
    Wisteria Floribunda Lectin (Biotin) (WFA (Biotin)) is a biotinylated lectin with affinity for N-acetyl-D-galactosamine.
    Wisteria Floribunda Lectin (Biotin)
  • HY-P0284A
    C-telopeptide TFA 98.38%
    C-telopeptide TFA, a cross-linked peptide of type I collagen, is released during bone resorption and has been correlated with bone mineral density (BMD).
    C-telopeptide TFA
  • HY-P10364
    Ubiquicidin(29-41) 216867-99-1 98.69%
    Ubiquicidin (29-41) (UBI (29-41)) is an Antimicrobial peptide and infection-localizing agent. Ubiquicidin (29-41) acts as an infection-specific imaging agent and infection-targeting agent. Ubiquicidin (29-41) serves as an antibiotic efficacy monitoring agent, and its aggregation level in infections induced by Staphylococcus aureus is higher than that in infections induced by Escherichia coli.
    Ubiquicidin(29-41)
  • HY-P10552
    pCXCL8-1aa 98.13%
    pCXCL8-1aa is an anti-inflammatory peptide. pCXCL8-1aa competitively inhibits the binding of CXCL8 to glycosaminoglycans such as heparin sulfate (HS) by binding with high affinity. This reduces the presentation of CXCL8 on the surface of vascular endothelial cells, thereby inhibiting neutrophil migration and inflammatory responses. pCXCL8-1aa can be used to study inflammatory diseases such as rheumatoid arthritis.
    pCXCL8-1aa
  • HY-P10664
    EBV EBNA3B (416-424) 147138-29-2 99.52%
    EBV EBNA3B (416-424) is an HLA-A11-restricted peptide antigen derived from EBV EBNA3B protein.
    EBV EBNA3B (416-424)
  • HY-P10728
    B7-33 1818415-56-3 99.31%
    B7-33 is a single-chain relaxin mimetic and a selective relaxin receptor 1 (RXFP1) agonist. B7-33 phosphorylates ERK1/2 without inducing activation of the cAMP signaling pathway. B7-33 exhibits anti-fibrotic and cardioprotective activities. B7-33 can be used in the research of vascular diseases such as cardiomyopathy, myocardial infarction and fibrosis.
    B7-33
  • HY-P10839
    NBD peptide 371915-62-7 98.02%
    NBD peptide inhibits NF-κB signaling pathway through inhibition of the NEMO-IKK complex combination. NBD peptide exhibits anti-inflammatory efficacy through block of pro-inflammatory cytokines production. NBD peptide exhibits immunosuppressive activity through regulation of immune cells. NBD peptide enhances its transmembrane ability by combining with cell-penetrating peptide HIV-TAT.
    NBD peptide
  • HY-P10940
    Ac-RFAAKAA-COOH 845727-63-1 99.54%
    Ac-RFAAKAA-COOH is a cysteine-containing polypeptide with a reactive lysine residue, and serves as a substrate for covalent modification and chemical reactivity assays. Ac-RFAAKAA-COOH forms stable covalent adducts with isothiocyanates, resulting in peptide depletion over time. Ac-RFAAKAA-COOH acts as a model peptide in direct peptide reactivity assays, where its chemical reactivity is evaluated via fluorescamine-based free amine assays. Ac-RFAAKAA-COOH can be used in studies related to allergic contact dermatitis and skin sensitization.
    Ac-RFAAKAA-COOH
  • HY-P11017
    LNSMGQD 1152066-26-6 99.92%
    LNSMGQD is a cyclic peptide fragment derived from desmoglein 1 (amino acids 81-86), which mimics trans-interactions and acts as part of the tandem peptide binding interface of desmoglein 2. LNSMGQD not only binds to desmoglein 1 and 3, but also effectively inhibits their homophilic trans-interactions, while reducing the probability of homophilic or heterophilic binding between desmoglein 2 and Dsc2, N-cadherin and E-cadherin. LNSMGQD is applicable to the research on disease mechanisms such as Crohn's disease and pemphigus vulgaris.
    LNSMGQD
  • HY-P11112
    PTD-DBM 1609454-11-6
    PTD-DBM is a CXXC5-Dvl protein-protein interaction inhibitor and also a Wnt/β-catenin pathway activator. PTD-DBM interferes with the Dvl-binding function of CXXC5, disrupts the negative feedback regulation of the Wnt/β-catenin pathway, induces β-catenin expression and nuclear translocation, and increases the production of type I collagen, α-smooth muscle actin and endothelin-1. PTD-DBM is applicable to studies related to androgenetic alopecia and skin wound healing.
    PTD-DBM
  • HY-P11115
    CIGB-552 1630763-23-3 98.66%
    CIGB-552 is a cell-penetrating peptide with anti-tumor properties with the IC50 of 23 μM in H460 cells. CIGB-552 can increase the level of protein COMMD1. CIGB-552 significantly inhibits the NF-κB signaling pathway. CIGB-552 can promote apoptosis of the tumor cells. CIGB-552 can induce the accumulation of reactive oxygen species (ROS) in tumor cells. CIGB-552 has anti-inflammatory and anti-angiogenic effects. CIGB-552 can be used for the research of the lung cancer and colon cancer.
    CIGB-552
  • HY-P11178
    Corisin 2651277-02-8 99.45%
    Corisin is a pro-apoptotic small peptide produced by Staphylococcus species. Corisin binds to serum albumin to target organs such as the lungs and kidneys, induces cellular senescence, apoptosis and epithelial-mesenchymal transition, and accelerates the progression of organ fibrosis including pulmonary fibrosis and diabetic renal fibrosis. Corisin levels are closely associated with coronavirus disease 2019 (COVID-19), diabetic chronic kidney disease (CKD), non-diabetic CKD, and idiopathic pulmonary fibrosis (IPF).
    Corisin
  • HY-P11273
    Urcosimod 1610366-43-2
    Urcosimod (OK 101) is a lipid-coupled chemokine peptide, a ChemR23 G protein-coupled receptor agonist, which has been shown to have anti-inflammatory and analgesic activities. Urcosimod can be used for dry eye research.
    Urcosimod
Cat. No. Product Name / Synonyms Application Reactivity