Ubiquicidin(29-41)
Based on 1 Customer Validation
Ubiquicidin (29-41) (UBI (29-41)) is an Antimicrobial peptide and infection-localizing agent. Ubiquicidin (29-41) acts as an infection-specific imaging agent and infection-targeting agent. Ubiquicidin (29-41) serves as an antibiotic efficacy monitoring agent, and its aggregation level in infections induced by Staphylococcus aureus is higher than that in infections induced by Escherichia coli.
For research use only. We do not sell to patients.
- Purity: 98.69%
- CAS No.: 216867-99-1
- Formula: C68H121N31O18S
- Molecular Weight:1692.95
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Storage:
Sealed storage, away from moisture.
Powder -80°C, 2 years , -20°C, 1 year* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
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Biological Activity
99mTc-labeled Ubiquicidin(29-41) binds preferentially to Staphylococcus aureus bacteria, with minimal binding to LS174T colon tumor cells and ACHN renal tumor cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
99mTc-UBI (29-41) (40 μg (10 MBq); intravenous injection; single administration) accumulates in the thigh muscle of rabbits infected with Staphylococcus aureus, with the average target-to-nontarget ratio peaking at up to 2.2 at 60 min post-injection[2].
99mTc-UBI (29-41) (40 μg (10 MBq); intravenous injection; single dose) accumulates in the thigh muscle of rabbits infected with E. coli, with an average target-to-nontarget ratio peaking at 1.7 at 60 min post-injection. This level is significantly lower than its accumulation level at S. aureus-infected sites[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:healthy immunocompetent rabbits (1.2-1.6 kg, average 1.4 kg)[2]
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Dosage:40 μg (10 MBq)
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Administration:i.v.; single dose
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Result:Showed visible accumulation at infected sites within 5-30 min post-injection.
Reached maximum mean T/NT ratio of 2.2 at 60 min post-injection.
Recorded highest individual T/NT ratio of 3.56 in one animal at 60 min post-injection.
Declined to mean T/NT ratio of 1.8 at 2 h, 1.7 at 3 h, and 1.5 at 4 h post-injection.\nShowed visible accumulation at infected sites within 5-30 min post-injection.
Reached maximum mean T/NT ratio of 1.7 at 60 min post-injection.
Recorded highest individual T/NT ratio of 2.45 in one animal at 30 min post-injection.
Had mean T/NT ratio of 1.2 at 5 min, 1.5 at 30 min, 1.4 at 2 h, 1.5 at 3 h, and 1.4 at 4 h post-injection.
Demonstrated significantly lower accumulation (P < 0.05) than at *S.
aureus*-infected sites at 60 min.
Chemical Information
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CAS No. 216867-99-1
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Appearance Solid
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Molecular Weight 1692.95
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Formula C68H121N31O18S
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Color White to off-white
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Synonyms
UBI(29-41)
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Sequence
Thr-Gly-Arg-Ala-Lys-Arg-Arg-Met-Gln-Tyr-Asn-Arg-Arg
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Sequence Shortening
TGRAKRRMQYNRR
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Sealed storage, away from moisture
Powder -80°C 2 years -20°C 1 year * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Purity & Documentation
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Data Sheet (263 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
[1]. Akhtar MS, et al. Antimicrobial peptides as infection imaging agents: better than radiolabeled antibiotics. Int J Pept. 2012;2012:965238. [Content Brief]
[2]. Akhtar MS, et al. 99mTc-labeled antimicrobial peptide ubiquicidin (29-41) accumulates less in Escherichia coli infection than in Staphlococcus aureus infection. J Nucl Med. 2004 May;45(5):849-56. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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