2. Inflammation/Immunology

Inflammation/Immunology

Inflammation/Immunology

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The diseases caused by disorders of the immune system fall into two broad categories: immunodeficiency and autoimmunity. Immunotherapy is also often used in the immunosuppressed (such as HIV patients) and people suffering from other immune deficiencies or autoimmune diseases. This includes regulating factors such as IL-2, IL-10, IFN-α. Infection with HIV is characterized not only by development of profound immunodeficiency but also by sustained inflammation and immune activation. Chronic inflammation as a critical driver of immune dysfunction, premature appearance of aging-related diseases, and immune deficiency.

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-N7123S
    Sulfacetamide-d4 99.04%
    Sulfacetamide-d4 (Sulphacetamide-d4) is the deuterium labeled Sulfacetamide (HY-N7123). Sulfacetamide (Sulphacetamide) is a sulfonamide antibiotic that can be used for the study of ocular infections. Sulfacetamide has antifungal and antibacterial activities.
    Sulfacetamide-d4
  • HY-N7560R
    Safranal (Standard) 116-26-7 99.89%
    Safranal (Standard) is an analytical standard for Safranal. This product is intended for research and analytical applications. Safranal is the main component of saffron (Crocus sativus), is orally active, and is the source of the spice's unique aroma. Safranal has neuroprotective and anti-inflammatory effects and has research potential for Parkinson's disease.
    Safranal (Standard)
  • HY-N7698A
    Penta-N-acetylchitopentaose 36467-68-2 99.94%
    Penta-N-acetylchitopentaose elicits plant defense systems. Penta-N-acetylchitopentaose is a substrate for the Rhizobium leguminosarum nodulation protein NodL.
    Penta-N-acetylchitopentaose
  • HY-N7926S
    Pentadecane-d32 36340-20-2 99.2%
    Pentadecane-d32 is the deuterium labeled Pentadecane (HY-N7926). Pentadecane is an orally active natural plant volatile alkane with anti-inflammatory, analgesic, antipyretic and anti-leishmanial activities. Pentadecane presents IC50 values of 65.3 μM, 60.5 μM and 194.8 μM against Leishmania infantum promastigotes, amastigotes and intracellular amastigotes, respectively. Pentadecane downregulates the mRNA expression of TNF-α and IL-12 and inhibits the release of inflammatory mediators. Pentadecane arrests the cell cycle of Leishmania infantum and induces apoptosis. Pentadecane can be applied to the research of inflammation and leishmaniasis.
    Pentadecane-d32
  • HY-NP0218
    Chicken Ovomucoid
    Chicken Ovomucoid is a major component of chicken ovalbumin, exhibiting trypsin inhibition and thermal stability.
    Chicken Ovomucoid
  • HY-NP0219
    Collagen petide (Fish)
    Collagen petide (Fish) is a fish-derived peptide. Collagen petide (Fish) promotes the multidirectional differentiation of various stem cell types.
    Collagen petide (Fish)
  • HY-NP182A
    Folic acid-BSA
    Folic acid-BSA (FA-BSA) is a conjugate of Folic acid (HY-16637) and BSA that improves the stability and solubility of Folic acid.
    Folic acid-BSA
  • HY-P0196A
    Cholecystokinin Octapeptide, desulfated TFA 171486-94-5
    Cholecystokinin Octapeptide, desulfated (CCK Octapeptide, desulfated) TFA is a synthetic desulfated Cholecystokinin octapeptide (HY-P0093).
    Cholecystokinin Octapeptide, desulfated TFA
  • HY-P0266A
    N-Acetyl-Ser-dAsp-Lys-Pro TFA 98%
    N-Acetyl-Ser-dAsp-Lys-Pro (TFA), an endogenous tetrapeptide secreted by bone marrow, is a specific substrate for the N-terminal site of ACE.
    N-Acetyl-Ser-dAsp-Lys-Pro TFA
  • HY-P0287A
    QL9 TFA
    QL9 (QLSPFPFDL) TFA is a high-affinity alloantigen for the 2C T cell receptor (TCR).
    QL9 TFA
  • HY-P10503
    S2-16 672333-56-1
    S2-16 is a synthetic peptide from the S2 region of cardiac myosin. S2-16 is a cryptic epitope that induces myocarditis in Lewis rats. A cryptic epitope is an epitope that is not recognized by antibodies or T cells after the animal is immunized with the intact antigen. S2-16 can be used to study the mechanism of autoimmune myocarditis.
    S2-16
  • HY-P1052A
    Myelin Basic Protein(87-99) TFA 99.23%
    Myelin Basic Protein(87-99) TFA is an encephalitogenic peptide that induces basic protein-specific T cell proliferation. Myelin Basic Protein(87-99) TFA causes a Th1 polarization in peripheral blood mononuclear cells with is implicated of multiple sclerosis (MS).
    Myelin Basic Protein(87-99) TFA
  • HY-P10813
    ZLIRTLHEWY 99.41%
    ZLIRTLHEWY is a potent peptide CD47/SIRPα interaction inhibitor. ZLIRTLHEWY is promising for research of cancers.
    ZLIRTLHEWY
  • HY-P10869
    dCNP
    dCNP binds to NPR-B/C receptor, activates cGMP signaling pathway, and regulates vascular function. dCNP exhibits anti-hypoxia property through downregulation of hypoxia-related genes expressions like HIF1α and HIF2α. dCNP inhibits the induction of tumor stroma and exhibits anti-fibrosis activity. dCNP upregulates CTLs, NK cells, and conventional type 1 dendritic cells in tumors, and activates immune responses.
    dCNP
  • HY-P10889
    CNI103 2366279-86-7 99.56%
    CNI103 is a highly potent and metabolically stable cell-permeable peptide inhibitor of calcineurin. CNI103 selectively blocks the interaction between calcineurin and NFATc3 (KD=16 nM), thereby preventing NFATc3 activation in vitro and in vivo. CNI103 can be used to study acute respiratory distress syndrome (ARDS) and other inflammatory diseases.
    CNI103
  • HY-P10897
    SjDX5-271 2767993-76-8 98.90%
    SjDX5-271 is a small 3 kDa peptide. SjDX5-271 inhibits the TLR4/MyD88/NF-κB signaling pathway. SjDX5-271 induces cell polarization. SjDX5-271 alleviats hepatic inflammation. SjDX5-271 protects mice against liver ischemia-reperfusion injury.
    SjDX5-271
  • HY-P10938
    LP17 (human) 887973-05-9
    LP17 (human) is a TREM1 antagonist peptide with anti-inflammatory and anti-cancer effects.
    LP17 (human)
  • HY-P11003
    PTD-N5-1 2088834-68-6
    PTD-N5-1 (N5-1) is an IRF5 inhibitory peptide. PTD-N5-1 blocks β-glucan-induced IL-12 production in IFN-γ primed wild-type and Clec2d-difecient bone-marrow-derived dendritic cells (BMDCs). PTD-N5-1 regulates antifungal immunity through suppression of IRF5-mediated IL-12 production.
    PTD-N5-1
  • HY-P11023
    E16-uPA24
    E16-uPA24 is a chimeric peptide targeting urokinase-type plasminogen activator receptor (uPAR). E16-uPA24 modifies senescent cells surface with polyglutamic acid, promoting immune cell-mediated responses through glutamate recognition. E16-uPA24 induces immune clearance of senescent cells and restores tissue homeostasis by enhancing immune cells recruitment and directly coupling senescent cells and immune cells. E16-uPA24 can be used for tissue degeneration, chronic inflammatory disease and age-related tumorigenesis research.
    E16-uPA24
  • HY-P11084
    WT1 126-134 peptide 256952-63-3 98.89%
    WT1 126-134 peptide is a Wilms' tumor oncogene protein (WT1) peptide (RMFPNAPYL). WT1 126-134 peptide is presented by HLA-A0201 and induces cytotoxic CD8 T cells capable of killing WT1+ positive tumor cells. WT1 126-134 can form stable complexes with the H-2Db (mouse) or HLA-A0201 (human) molecules. WT1 126-134 peptide/HLA-A0201 complex has an extremely high affinity (Kd = 0.2 nM) with the humanized monoclonal antibody (IgG1). WT1 126-134 peptide can be used as a vaccine for T cells or as a target for antibodies.
    WT1 126-134 peptide
Cat. No. Product Name / Synonyms Application Reactivity