PTD-N5-1
PTD-N5-1 is an IRF5 inhibitory peptide. PTD-N5-1 blocks the activation of IRF5. PTD-N5-1 inhibits β-glucan-induced IL-12 production in bone marrow-derived dendritic cells pre-stimulated with IFN-γ. PTD-N5-1 reduces the levels of IL-12 and IFN-γ in the kidneys of mice with Candida albicans infection. PTD-N5-1 is applicable to the research of Candida albicans infection.
For research use only. We do not sell to patients.
- CAS No.: 2088834-68-6
- Formula: C148H248N52O30S
- Molecular Weight:3267.95
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
Biological Activity
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IRF5 |
IFN-γ |
IL-12 |
PTD-N5-1 (N5-1) (50 μM) completely blocks β-glucan-induced IL-12p70 production in IFN-γ-primed wild-type and Clec2d-deficient mouse bone marrow-derived dendritic cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:IFN-γ-primed wild-type mouse bone marrow-derived dendritic cells (BMDCs), IFN-γ-primed Clec2d-deficient mouse bone marrow-derived dendritic cells (BMDCs)
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Concentration:50 μM
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Incubation Time:6 h (stimulation with curdlan plus IFN-γ; pretreatment prior to stimulation)
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Result:Completely blocked β-glucan-induced IL-12p70 production in IFN-γ-primed wild-type BMDCs.
Completely blocked β-glucan-induced IL-12p70 production in IFN-γ-primed Clec2d-deficient BMDCs.
Chemical Information
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CAS No. 2088834-68-6
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Molecular Weight 3267.95
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Formula C148H248N52O30S
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Sequence
Asp-Arg-Gln-Ile-Lys-Ile-Trp-Phe-Gln-Asn-Arg-Arg-Met-Lys-Trp-Lys-Lys-Pro-Arg-Arg-Val-Arg-Leu-Lys
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Sequence Shortening
DRQIKIWFQNRRMKWKKPRRVRLK
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)