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Cat. No.: HY-P11003A

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PTD-N5-1 acetate

PTD-N5-1 acetate is an IRF5 inhibitory peptide. PTD-N5-1 acetate blocks the production of IL-12p70 in zymosan-induced, IFN-γ-prestimulated wild-type and Clec2d-deficient bone marrow-derived dendritic cells (BMDCs). PTD-N5-1 acetate regulates antifungal immunity by inhibiting IRF5-mediated IL-12 production. PTD-N5-1 acetate can be used in studies related to fungal infections.

For research use only. We do not sell to patients.

Formula: C₁₄₈H₂₄₈N₅₂O₃₀S·xC₂H₄O₂
Molecular Weight:3267.95 (free base)

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Custom Peptide Synthesis

PTD-N5-1 acetate Chemical Structure

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
- In Vivo
Chemical Information
Solvent & Solubility
- In Vitro
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

IC₅₀ & Target^[1]

IL-12

All Toll-like Receptor (TLR) Isoforms :

All Interleukin Related Isoforms :

In Vitro

PTD-N5-1 (compound N5-1) (50 μM; 6 h) acetate potently blocks curdlan-induced IL-12p70 production in IFN-γ-primed wild-type and Clec2d-deficient BMDCs^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

ELISA Assay^[1]

Cell Line:

IFN-γ-primed wild-type bone marrow-derived dendritic cells (BMDCs), IFN-γ-primed Clec2d-deficient bone marrow-derived dendritic cells (BMDCs)
Concentration:

50 μM
Incubation Time:

6 h (stimulation with curdlan plus IFN-γ after pretreatment)
Result:

Completely blocked β-glucan (curdlan)-induced IL-12p70 production in IFN-γ-primed wild-type BMDCs.
Completely blocked β-glucan (curdlan)-induced IL-12p70 production in IFN-γ-primed Clec2d-deficient BMDCs.

In Vivo

PTD-N5-1 (compound N5-1) (100 μg/mouse; pretreatment before infection) acetate significantly increases fungal burden and reduces renal IL-12p70 and IFN-γ production in myeloid cell-specific Clec2d-deficient mice infected with Candida albicans^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

Molecular Weight 3267.95 (free base)
Formula C₁₄₈H₂₄₈N₅₂O₃₀S·xC₂H₄O₂
Sequence

Asp-Arg-Gln-Ile-Lys-Ile-Trp-Phe-Gln-Asn-Arg-Arg-Met-Lys-Trp-Lys-Lys-Pro-Arg-Arg-Val-Arg-Leu-Lys
Sequence Shortening

DRQIKIWFQNRRMKWKKPRRVRLK
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Solvent & Solubility

In Vitro:

H₂O : 10 mg/mL (Need ultrasonic)

View the Complete Stock Solution Preparation Table

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Li F, et al. C-type lectin receptor 2d forms homodimers and heterodimers with TLR2 to negatively regulate IRF5-mediated antifungal immunity. Nature communications. 2023 Oct 23;14(1):6718. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

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100 mg

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Amount: USD 0.00

Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
- In Vivo
Chemical Information
Solvent & Solubility
- In Vitro
Purity & Documentation
References

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PTD-N5-1 acetate

All Toll-like Receptor (TLR) Isoforms

All Interleukin Related Isoforms