PTD-N5-1 acetate
Based on 1 Customer Validation
PTD-N5-1 acetate is an IRF5 inhibitory peptide. PTD-N5-1 acetate blocks the activation of IRF5. PTD-N5-1 acetate inhibits β-glucan-induced IL-12 production in bone marrow-derived dendritic cells pre-stimulated with IFN-γ. PTD-N5-1 acetate reduces the levels of IL-12 and IFN-γ in the kidneys of mice with Candida albicans infection. PTD-N5-1 acetate is applicable to the research of Candida albicans infection.
For research use only. We do not sell to patients.
- Purity: 99.30%
- Formula: C148H248N52O30S·xC2H4O2
- Molecular Weight:3267.95 (free base)
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Storage:
Sealed storage, away from moisture.
Powder -80°C, 2 years , -20°C, 1 year* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Description
IC50 & Target
[1]|
IRF5 |
IFN-γ |
IL-12 |
In Vitro
PTD-N5-1 (N5-1) (50 μM) acetate completely blocks β-glucan-induced IL-12p70 production in IFN-γ-primed wild-type and Clec2d-deficient mouse bone marrow-derived dendritic cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:IFN-γ-primed wild-type mouse bone marrow-derived dendritic cells (BMDCs), IFN-γ-primed Clec2d-deficient mouse bone marrow-derived dendritic cells (BMDCs)
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Concentration:50 μM
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Incubation Time:6 h (stimulation with curdlan plus IFN-γ; pretreatment prior to stimulation)
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Result:Completely blocked β-glucan-induced IL-12p70 production in IFN-γ-primed wild-type BMDCs.
Completely blocked β-glucan-induced IL-12p70 production in IFN-γ-primed Clec2d-deficient BMDCs.
In Vivo
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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Appearance Solid
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Molecular Weight 3267.95 (free base)
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Formula C148H248N52O30S·xC2H4O2
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Color White to off-white
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Sequence
Asp-Arg-Gln-Ile-Lys-Ile-Trp-Phe-Gln-Asn-Arg-Arg-Met-Lys-Trp-Lys-Lys-Pro-Arg-Arg-Val-Arg-Leu-Lys
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Sequence Shortening
DRQIKIWFQNRRMKWKKPRRVRLK
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Sealed storage, away from moisture
Powder -80°C 2 years -20°C 1 year * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Solvent & Solubility
In Vitro:
H2O : 10 mg/mL (Need ultrasonic)
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
PTD-N5-1 acetate Related Classifications
HY-P11003A Related Classifications
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