2. Inflammation/Immunology

Inflammation/Immunology

Inflammation/Immunology

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The diseases caused by disorders of the immune system fall into two broad categories: immunodeficiency and autoimmunity. Immunotherapy is also often used in the immunosuppressed (such as HIV patients) and people suffering from other immune deficiencies or autoimmune diseases. This includes regulating factors such as IL-2, IL-10, IFN-α. Infection with HIV is characterized not only by development of profound immunodeficiency but also by sustained inflammation and immune activation. Chronic inflammation as a critical driver of immune dysfunction, premature appearance of aging-related diseases, and immune deficiency.

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-B1733
    Phenyltoloxamine 92-12-6 98%
    Phenyltoloxamine (Bistrimin) is an antihistamine agent with sedative and analgesic effects. Phenyltoloxamine also has potent Sigma-1 receptor binding affinity (Ki: 160 nM).
    Phenyltoloxamine
  • HY-B1754
    Rimexolone 49697-38-3 98%
    Rimexolone (Org 6216) is a glucocorticoid steroid with anti-inflammatory activity. Rimexolone can be used as a 1% ophthalmic suspension for the management of ocular inflammation.
    Rimexolone
  • HY-B1888
    Bromfenac 91714-94-2 98%
    Bromfenac is a potent and orally active inhibitor of COX, with IC50s of 5.56 and 7.45 nM for COX-1 and COX-2, respectively. Bromfenac can be used in ocular inflammation research.
    Bromfenac
  • HY-B2056
    Triforine 26644-46-2 98%
    Triforine (CELA W 524), a systemic fungicide, was shown to display a moderate to distinct fungitoxic activity in vitro towards several pathogenic and non-pathogenic fungi.
    Triforine
  • HY-B2078
    Eprazinone 10402-90-1 98%
    Eprazinone can enhance lung function and arterial oxygen levels and can be used in the study of chronic bronchitis. Higher doses of eprazinone increased phospholipid levels and decreased neutral lipid content in bronchoalveolar lavage (BAL) fluid, but had no effect on protein and cell levels in BAL. Eprazinone dose-dependently reduced short-circuit current (Isc), primarily by reducing chloride secretion at lower concentrations and affecting sodium and chloride transport at higher doses. Eprazinone may exert its anti-inflammatory effects by regulating BAL lipid composition and airway ion transport.
    Eprazinone
  • HY-B2096
    Oleic acid ethanolamine 2272-11-9 98%
    Oleic (9-cis-Octadecenoic) acid ethanolamine consists of oleic acid and ethanolamine. Oleic acid ethanolamine has sclerotherapeutic activity. Oleic acid ethanolamine can cause inflammatory reaction in the intimal endothelium of the vein.
    Oleic acid ethanolamine
  • HY-B2178
    Emedastine difumarate 87233-62-3 98%
    Emedastine difumarate is an orally active, selective and high affinity histamine H1 receptor antagonist with a Ki value of 1.3 nM. Emedastine difumarate is a benzimidazole derivative with potent antiallergic properties and used for allergic rhinitis, allergic skin diseases and allergic conjunctivitis.
    Emedastine difumarate
  • HY-B2185
    Tipepidine citrate 14698-07-8 98%
    Tipepidine citrate is a non-narcotic antitussive agent. Tipepidine citrate reversibly inhibits dopamine D2 receptor-mediated GIRK current (IDA(GIRK)), thereby activating VTA dopamine neurons, with an IC50 of 7.0 μM for IDA(GIRK). Tipepidine activates AMPK. Tipepidine citrate has antidepressant-like effects. Tipepidine citrate enhances the analgesic effect of Carbamazepine (HY-B0246). Tipepidine citrate improves adipose tissue fibrosis and glucose intolerance in high-fat diet-induced obese mice.
    Tipepidine citrate
  • HY-D0038
    BTBCT 525560-81-0 98%
    BTBCT is mainly used as a label in time-resolved fluorescence immunoassays (TRFIA). The lower limit of detection for TSH TR-IFMA is 0.011 mIU/L in a 10 μl sample volume. The high fluorescence intensity and stability of BTBCT improves the sensitivity of the assay.
    BTBCT
  • HY-D1199
    Blue FPG-A trisodium 78617-94-4 98%
    Blue FPG-A trisodium is a selective antagonist of P2X1 receptor and P2Y1 receptor with IC50 values of 35.5 μM and 2.6 μM, respectively. Blue FPG-A trisodium is a structural isomer of the components of Reactive Blue 2 (RB2).
    Blue FPG-A trisodium
  • HY-D1274
    Sulfo-cyanine3 azide 1658416-54-6 98%
    Sulfo-cyanine3 azide is an azide cyanine dye and fluorescent probe (Ex/Em=548/563 nm). Sulfo-cyanine3 azide can be involved in synthesis of fused tricyclic heterocycles, produces immunostimulatory agents. It contains an azide group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing alkyne groups. It can also undergo ring strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing DBCO or BCN groups.
    Sulfo-cyanine3 azide
  • HY-D1286
    Serum CG probe 1 98%
    Serum CG probe 1 (formula (9)) is a compound for determining serum cholyglycine.
    Serum CG probe 1
  • HY-D1287
    Serum CG probe 2 98%
    Serum CG probe 2 (formula (15)) is a compound for determining serum cholyglycine.
    Serum CG probe 2
  • HY-D1782
    Selenomethylene blue 85670-01-5
    Selenomethylene blue is an antioxidant and anti-inflammatory agent. Selenomethylene blue effectively inhibits the inflammatory paw edema in rats.
    Selenomethylene blue
  • HY-D2004
    ATTO 488 streptavidin 1430816-27-5 98%
    ATTO 488 streptavidin is a fluorescent reagent that specifically targets and binds to biotin (biotin), formed by the conjugation of ATTO 488 with streptavidin (HY-P3152). ATTO 488 streptavidin enables visualization of the activity of streptavidin immobilized on the surface of polymeric nanoparticles, or acts as a fluorescent probe to detect the selective binding and internalization process of anti-HB-EGF/NA with cells expressing HB-EGF (with no such effect on cells that do not express this receptor). ATTO 488 streptavidin effectively verifies the function of streptavidin conjugated to the surface of nanoparticles and is suitable for research related to atherosclerotic cardiovascular diseases.
    ATTO 488 streptavidin
  • HY-D2094
    PerCP Maleimide 98%
    PerCP Maleimide is a fluorescent dye that reacts with free sulfhydryl groups on proteins. PerCP is a red fluorescence albuminous dye for immunostaining and Maleimide can be leveraged for the preparation of fluorogenic probe, which is mainly used for the specific detection of thiol analytes.
    PerCP Maleimide
  • HY-D2279
    NFL-NH2 98%
    NFL-NH2 is a mitochondrial-targeted near-infrared ratiometric fluorescent probe. NFL-NH2 can rapidly detect NO levels associated with the inflammatory damage degree in rheumatoid arthritis (RA) mice models by ratiometric fluorescence imaging. The excitation wavelength and emission wavelength are 650 nm and 780 nm, respectively.
    NFL-NH2
  • HY-D2310
    CXCR2 Probe 1 98%
    CXCR2 Probe 1 (Compound [18F]16b) is a selective ligand for CXCR2 and is a radiotracer for PET imaging of neutrophils in inflammatory diseases.
    CXCR2 Probe 1
  • HY-D2333
    RhFNMB 98%
    RhFNMB is a dualchannel/localization single-molecule fluorescence probe for ATP and HOCl, with independent fluorescence responses in the light red channel with ATP (λex = 520 nm, λem = 586 nm) and deep red channel with HOCl (λex = 620 nm, λem = 688 nm).
    RhFNMB
  • HY-D3005
    NpCy-4
    NpCy-4 is a reliable reporter for monitoring lysosomal pH and viscosity changes in real time during Autophagy (λex = 650 nm; λem = 660-740 nm). NpCy-4 demonstrates a superior signal-to-background ratio (SBR) for cellular imaging. NpCy-4 facilitates real-time, noninvasive diagnostic imaging of acute gastritis model with high contrast.
    NpCy-4
Cat. No. Product Name / Synonyms Application Reactivity