Phenyltoloxamine
Phenyltoloxamine (Bistrimin) is an antihistamine agent with sedative and analgesic effects. Phenyltoloxamine also has potent Sigma-1 receptor binding affinity (Ki: 160 nM).
For research use only. We do not sell to patients.
- CAS No.: 92-12-6
- Formula: C17H21NO
- Molecular Weight:255.35
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Storage:Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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Sigma 1 Receptor 160 nM (Ki) |
Phenyltoloxamine (10-50 μM, 24 h) demonstrates cytotoxicity in EVSA-T cells[2].
Phenyltoloxamine exhibits potent Sigma 1 Receptor (S1R) binding affinity with a Ki value of 160 nM[3].
Phenyltoloxamine (100 μM) inhibits human liver macrosaml CYP2D6 enzyme by 99.0%[4].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 92-12-6
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Appearance Solid
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Molecular Weight 255.35
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Formula C17H21NO
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SMILES
CN(C)CCOC1=CC=CC=C1CC2=CC=CC=C2
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Synonyms
Bistrimin; Histionex
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month
Purity & Documentation
References
[2]. Brandes LJ, et al. Evidence that the antiestrogen binding site is a histamine or histamine-like receptor. Biochem Biophys Res Commun. 1985 Jan 31;126(2):905-10. [Content Brief]
[3]. Youyi Peng, et al. Comprehensive 3D-QSAR Model Predicts Binding Affinity of Structurally Diverse Sigma 1 Receptor Ligands. J Chem Inf Model. 2019 Jan 28;59(1):486-497. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Phenyltoloxamine Related Classifications
HY-B1733 Related Classifications
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