92-12-6
92-12-6
Chemical Structure
Phenyltoloxamine
Synonym(s): Bistrimin; Histionex
- CAS No.: 92-12-6
- Formula:C17H21NO
- Molecular Weight:255.35
IUPAC Name: 2-(2-benzylphenoxy)-N,N-dimethylethan-1-amine
InChIKey: IZRPKIZLIFYYKR-UHFFFAOYSA-N
SMILES: CN(C)CCOC1=CC=CC=C1CC2=CC=CC=C2
Biological Activity: Phenyltoloxamine (Bistrimin) is an antihistamine agent with sedative and analgesic effects. Phenyltoloxamine also has potent Sigma-1 receptor binding affinity (Ki: 160 nM)[1][2][3].
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Phenyltoloxamine | Phenyltoloxamine (Bistrimin) is an antihistamine agent with sedative and analgesic effects. Phenyltoloxamine also has potent Sigma-1 receptor binding affinity (Ki: 160 nM). | |||||||||||||||||||||
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References
- [1]. Justin B.Hoekstra. Pharmacological Properties of a New Antihistaminic Agent, Phenyltoloxamine (Bristamin). Journal of the American Pharmaceutical Association (Scientific ed.). 1953, 42 (10), 587-593.
- [2]. Brandes LJ, et al. Evidence that the antiestrogen binding site is a histamine or histamine-like receptor. Biochem Biophys Res Commun. 1985 Jan 31;126(2):905-10. [Content Brief]
- [3]. Youyi Peng, et al. Comprehensive 3D-QSAR Model Predicts Binding Affinity of Structurally Diverse Sigma 1 Receptor Ligands. J Chem Inf Model. 2019 Jan 28;59(1):486-497. [Content Brief]
Keywords
