2. Inflammation/Immunology

Inflammation/Immunology

Inflammation/Immunology

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The diseases caused by disorders of the immune system fall into two broad categories: immunodeficiency and autoimmunity. Immunotherapy is also often used in the immunosuppressed (such as HIV patients) and people suffering from other immune deficiencies or autoimmune diseases. This includes regulating factors such as IL-2, IL-10, IFN-α. Infection with HIV is characterized not only by development of profound immunodeficiency but also by sustained inflammation and immune activation. Chronic inflammation as a critical driver of immune dysfunction, premature appearance of aging-related diseases, and immune deficiency.

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-176881
    ASK1-IN-10 2247064-84-0
    ASK1-IN-10 (Compound 27) is an apoptosis signal-regulating kinase 1 (ASK1) inhibitor with an IC50 <200 nM. ASK1-IN-10 also shows inhibitory activity to hERG potassium channels. ASK1-IN-10 can be used for the research of inflammation.
    ASK1-IN-10
  • HY-176882
    ASK1-IN-11 2247064-44-2
    ASK1-IN-11 (Compound 7) is an apoptosis signal-regulating kinase 1 (ASK1) inhibitor with an IC50 <200 nM. ASK1-IN-11 also shows inhibitory activities to TNF-α, MYLK/MLCK Kinase and hERG potassium channels . ASK1-IN-11 can be used for the research of inflammation.
    ASK1-IN-11
  • HY-176914
    Myosin-IN-3 3103487-72-2 98%
    Myosin-IN-3 (Compound 4-1) is a pyrimidine ketone derivative. Myosin-IN-3 exhibits significant anti ferroptotic activity (IC50 = 3.11 μM) while possessing myosin (IC50 = 3.09 μM) inhibitory activity and antioxidant activity (DPPH EC50 = 23.17 μM; MDA EC50 = 55.34 μM). Myosin-IN-3 can be used for research on heart conditions such as hypertrophic cardiomyopathy.
    Myosin-IN-3
  • HY-176923
    1,3-Bis(isothiocyanatomethyl)benzene 28170-90-3
    1,3-Bis(isothiocyanatomethyl)benzene is a plant regulator. prevents the invasion of pathogens by inducing stomatal closure. 1,3-Bis(isothiocyanatomethyl)benzene significantly increases the levels of ROS and NO in guard cells. 1,3-Bis(isothiocyanatomethyl)benzene has shown significant control effects on grape downy mildew, cucumber downy mildew, and wheat leaf rust.
    1,3-Bis(isothiocyanatomethyl)benzene
  • HY-176929
    BET-IN-29 1776060-36-6
    BET-IN-29 (Compound 1) is a bromodomain and the terminal motif (BET) inhibitor. BET-IN-29 can be used for the study of cancer, inflammation, metabolism, neurological diseases, and infectious diseases.
    BET-IN-29
  • HY-176965
    N-Cholyl-L-threonine 103444-73-1 98%
    N-Cholyl-L-threonine (ThrCA) is a Cholic acid (HY-N0324) conjugated with L-threonine (HY-N0658). N-Cholyl-L-threonine possesses PXR agonism activity. N-Cholyl-L-threonine can be used in the research of Crohn's disease.
    N-Cholyl-L-threonine
  • HY-176966
    Cholyl-L-tyrosine 18485-51-3 98%
    Cholyl-L-tyrosine (TyrCA) is a cholyl conjugate of L-tyrosine (HY-N0473). Cholyl-L-tyrosine can be effectively hydrolyzed by pancreatic juice.
    Cholyl-L-tyrosine
  • HY-176967
    N-Cholyl-L-glutamic acid 23828-78-6 98%
    N-Cholyl-L-glutamic acid (GluCA) is a Cholic acid (HY-N0324) conjugated with L-glutamic acid (HY-14608). N-Cholyl-L-glutamic acid increases expression of PXR and downstream PXR-target gene Cyp3a11. N-Cholyl-L-glutamic acid can be used in the research of Crohn's disease.
    N-Cholyl-L-glutamic acid
  • HY-176968
    N-Cholyl-L-aspartic acid 18416-55-2 98%
    N-Cholyl-L-aspartic acid (AspCA) is a N-cholyl Amino Acid (HY-168761) derivative. N-Cholyl-L-aspartic acid can be used for the study of inflammatory bowel disease (IBD).
    N-Cholyl-L-aspartic acid
  • HY-177006
    JAK1/2-IN-2 1470249-04-7
    JAK1/2-IN-2 (Compound 37) is a potent and selective JAK1/2 inhibitor with Ki values of 2 and 0.6 nM .
    JAK1/2-IN-2
  • HY-177050
    RG-239 1199222-56-4 98%
    RG-239 is an orally active TGR5 agonist with an EC50 of 120 nM, significantly outperforming Betulinic acid (HY-10529) (EC50 = 1.04 μM). RG-239 demonstrates higher selectivity for TGR5 compared to the FXRα. RG-239 increases mitochondrial activity in adipocytes and promotes neurite outgrowth at higher concentrations. RG-239 inhibits LPS (HY-D1056)-induced iNOS expression and nitrite production in Raw264.7 and microglia cells. RG-239 can be used for the study of type 2 diabetes[1][2][3][4][5].
    RG-239
  • HY-177070
    Angexostat 2640653-91-2 98%
    Angexostat (Compound 2) is an inhibitor of xanthine oxidase. Angexostat exhibits high permeability. Angexostat inhibits CYP2C9 with an IC50 of 18.1 μM. Angexostat can be studied in research for xanthine oxidase-related diseases such as hyperuricemia and gout.
    Angexostat
  • HY-177077
    Davalomilast 2379980-45-5
    Davalomilast (Example 100) is an PDE4 inhibitor with anti-inflammatory property. Davalomilast can be studied in research for autoimmune diseases and dermatology research.
    Davalomilast
  • HY-177091
    AS2795440 2171506-45-7
    AS2795440 is a PIKfyve inhibitor. AS2795440 selectively inhibits proinflammatory cytokine such as IL-12p40 and IL-6 production and B cell activation without affecting Ca2+ signaling. AS2795440 significantly reduces joint inflammation and bone loss in adjuvant-induced arthritis (AIA) mice model. AS2795440 can be used for inflammatory and autoimmune diseases like rheumatoid arthritis, psoriasis and inflammatory bowel disease research.
    AS2795440
  • HY-177123
    Refinicopan 2922808-66-8 98%
    Refinicopan is a complement factor D inhibitor with an IC50 of 10 nM. Refinicopan inhibits hemolysis of rabbit red blood cells. Refinicopan can be used to study diseases mediated by complement factor D.
    Refinicopan
  • HY-177128
    Sebrinoflast 2919854-67-2
    Sebrinoflast (Compound 5) is a NLRP3 inhibitor with an IC50 ≤1  μM for hNLRP3. Sebrinoflast can be used for inflammatory and cardiovascular diseases including NASH and atherosclerosis and neurological diseases like Alzheimer's disease research.
    Sebrinoflast
  • HY-177131
    Soficitinib 2574524-67-5 98%
    Soficitinib (Compound 20) is a selective tyrosine kinase 2 (TYK2) and Janus kinase 2 (JAK2) inhibitor, with IC50 values of 0.5 nM and 1.2 nM, respectively. Soficitinib shows promise for research into autoimmune diseases (such as psoriasis, rheumatoid arthritis) and inflammatory diseases.
    Soficitinib
  • HY-177136
    ACLY-IN-2 3009136-86-8
    ACLY-IN-2 (Compound 7) has inhibitory effect against human ATP citrate lyase (hACLY), with an IC50 of less than 1 nM. ACLY-IN-2 can be studied in research on liver-related diseases, type-2 diabetes, autoimmunity, and cancer.
    ACLY-IN-2
  • HY-177155
    p38α-IN-10 180869-29-8
    P38α-IN-10 (Compound 8) is an orally active inhibitor of p38α, with an IC₅₀ of 230 nM. P38α-IN-10 has an inhibitory effect on TNF production induced by LPS (HY-D1056). P38α-IN-10 can be used for the study of diseases such as rheumatoid arthritis and septic shock.
    p38α-IN-10
  • HY-177271
    PHD2-IN-6 1193382-79-4
    PHD2-IN-6 (Example 89) is a HIF prolyl hydroxylase 2 (PHD2) inhibitor with an IC50 of 31.6  nM. PHD2-IN-6 stimulates encoding erythropoietin (EPO) production. PHD2-IN-6 can be used for inflammatory diseases like inflammatory bowel disease (IBD) and rheumatoid arthritis research.
    PHD2-IN-6
Cat. No. Product Name / Synonyms Application Reactivity