2. Metabolic Disease

Metabolic Disease (代謝)

Metabolic Disease

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Metabolic diseases is defined by a constellation of interconnected physiological, biochemical, clinical, and metabolic factors that directly increases the risk of cardiovascular disease, type 2 diabetes mellitus, and all cause mortality. Associated conditions include hyperuricemia, fatty liver (especially in concurrent obesity) progressing to nonalcoholic fatty liver disease, polycystic ovarian syndrome (in women), erectile dysfunction (in men), and acanthosis nigricans. Metabolic disease modeling is an essential component of biomedical research and a mandatory prerequisite for the treatment of human disease. Somatic genome editing using CRISPR/Cas9 might be used to establish novel metabolic disease models.

製品番号 製品名 CAS 番号 純度 構造式
  • HY-P1503
    ACTH (4-11) 67224-41-3 98.48%
    ACTH (4-11), an adrenocorticotropin hormone fragment, possesses a weak α-melanocyte stimulating hormone (α-MSH) potency only at high doses (100 and 1000 nM).
    ACTH (4-11)
  • HY-P1518
    Adrenocorticotropic Hormone (ACTH) (1-10), human 2791-05-1 98.26%
    Adrenocorticotropic Hormone (ACTH) (1-10), human, an adrenocorticotropin hormone fragment, possesses a weak α-melanocyte stimulating hormone (α-MSH) potency only at high doses (100 and 1000 nM).
    Adrenocorticotropic Hormone (ACTH) (1-10), human
  • HY-P1541
    Motilin, canine 85490-53-5 98.63%
    Motilin, canine is a 22-amino acid peptide. Motilin is a potent agonist for gastrointestinal smooth muscle contraction.
    Motilin, canine
  • HY-P1955
    Etelcalcetide 1262780-97-1 98%
    Etelcalcetide (AMG 416; KAI-4169) is a synthetic calcimimetic as an activator of the calcium sensing receptor (CaSR). Etelcalcetide is effective in lowering parathyroid hormone (PTH) concentrations in patients receiving dialysis with secondary hyperparathyroidism receiving hemodialysis, which is promising for research in the field of secondary hyperparathyroidism and chronic kidney disease.
    Etelcalcetide
  • HY-P2168
    Demoxytocin 113-78-0 98.34%
    Demoxytocin is a heterologous cyclic peptide and an analog of Oxytocin (HY-17571). Demoxytocin affects the permeability of cell membranes and increases calcium ion levels in smooth muscle cells, thereby enhancing the contraction of smooth muscle cells. Demoxytocin also stimulates the contraction of uterine smooth muscle. Demoxytocin possesses the functions of oxytocin. Demoxytocin can be used to study labor stimulation in preterm premature rupture of membranes.
    Demoxytocin
  • HY-P2281
    Atrial natriuretic factor (1-28) (human, porcine) 91917-63-4 98%
    Atrial natriuretic factor (1-28) (human, porcine) exhibits blood pressure lowering activity by increasing sodium and urine excretion. Atrial natriuretic factor (1-28) (human, porcine) inhibits the release of pituitary adrenocorticotropic hormone (ACTH) and beta-endorphin through inhibition of pro-opiomelanocortin (POMC) expression. Atrial natriuretic factor (1-28) (human, porcine) increases cGMP levels in RMIC cells with an IC50 of 1.2 nM.
    Atrial natriuretic factor (1-28) (human, porcine)
  • HY-P2325
    Exoenzyme C3, clostridium botulinum 58319-92-9
    Exoenzyme C3, clostridium botulinum, is a mono-ADP-ribosylating enzyme. Exoenzyme C3, clostridium botulinum specifically modifies RhoA, B, and C by transferring ADP-ribose to them, thereby inactivating these GTPases. Exoenzyme C3, clostridium botulinum can induce neuronal axonal and dendritic growth, inhibit macrophage migration, and regulate cytoskeletal dynamics. Exoenzyme C3, clostridium botulinum can be used in the research of spinal cord injury and diabetic painful neuropathy.
    Exoenzyme C3, clostridium botulinum
  • HY-P2510
    Parathyroid Hormone (1-34), human, biotinylated 99.49%
    Parathyroid Hormone (1-34), human, biotinylated is a probe for the parathyroid hormone receptor, can be used for analyzing the interaction between parathyroid hormone and parathyroid hormone receptors in living cells and for purifying hormone-receptor complexes with affinity columns.
    Parathyroid Hormone (1-34), human, biotinylated
  • HY-P2588
    Osteocalcin (human) 136461-80-8
    Osteocalcin (Osteocalcin (1-49)) (human) is a vitamin K-dependent bone specific protein. Osteocalcin (human) is chemotactic for several of the cell types frequently found at bone remodeling surfaces.
    Osteocalcin (human)
  • HY-P2636
    Cholecystokinin Precursor (24-32) (rat) 99291-20-0 99.54%
    Cholecystokinin Precursor (24-32) (rat) is a cholecystokinin precursor that can be expressed in the heart, lungs, and kidneys as well as in the gastrointestinal tract and brain. Cholecystokinin is a brain-gut peptide that stimulates gallbladder contraction and pancreatic exocrine secretion and also acts as a neurotransmitter.
    Cholecystokinin Precursor (24-32) (rat)
  • HY-P2677
    CCK (26-31) sulfated 89911-65-9
    CCK (26-31) (sulfated) is the N-terminal fragment of CCK, a peptide hormone found in the gut and brain that stimulates digestion, regulates satiety, and is associated with anxiety.
    CCK (26-31) sulfated
  • HY-P2725
    Glycerol dehydrogenase 9028-14-2
    Glycerol dehydrogenase is a polyol dehydrogenase that catalyzes the NAD-dependent oxidation of glycerol to dihydroxyacetone. Glycerol dehydrogenase can be used for glycerol metabolism in diverse microorganisms.
    Glycerol dehydrogenase
  • HY-P2735
    Phosphorylase b 9012-69-5
    Phosphorylase b is one of the two forms of phosphorylase present in skeletal muscle. The other is Phosphorylase a, which can be transformed into one another. The conversion process requires the addition of divalent metal ions and ATP.
    Phosphorylase b
  • HY-P2736
    Amidase 9012-56-0
    Amidases, a member of nitrilase superfamily, catalyzes the hydrolysis of an amide, leading to the formation of carboxylic acid and ammonia. Amidases contain a conserved stretch of approximately 130 amino acids known as the AS sequence, and play a role in important metabolic processes.
    Amidase
  • HY-P2758
    Diamine oxidase 9001-53-0
    Diamine oxidase (DAO) is an orally active enzyme. Diamine oxidase catalyzes oxidative deamination of various polyamines. Diamine oxidase degrades histamine and polyamines to maintain the metabolic balance of amines in the body. Diamine oxidase is a key regulatory enzyme in rapidly proliferating tissues such as bone marrow and intestinal mucosa. Diamine oxidase can be used in research related to intestinal diseases, small bowel transplant rejection, histamine intolerance, and other conditions.
    Diamine oxidase
  • HY-P2836
    (R)-Mandelonitrile lyase 9024-43-5
    (R)-Mandelonitrile lyase (Mandelonitrile Lyase) is an enzyme that can be isolated from Prunus species.
    (R)-Mandelonitrile lyase
  • HY-P2843
    Citrate lyase 9012-83-3
    Citrate lyase is an enzyme that converts citrate to oxaloacetate.
    Citrate lyase
  • HY-P2944
    Ferredoxin-NADP reductase 9029-33-8
    Ferredoxin-NADP reductase in plants receives electrons from ferredoxin (Fd) at the end of the photosynthetic electron transfer chain and converts NADP+ to NADPH.
    Ferredoxin-NADP reductase
  • HY-P2956
    Fructose 5-dehydrogenase (acceptor) 37250-85-4
    Fructose 5-dehydrogenase (acceptor) (D-Fructose dehydrogenase) is a membrane-bound flavohemo-protein that catalyzes the oxidation of d-fructose to 5-keto-d-fructose. Fructose 5-dehydrogenase (acceptor) consists of three subunits: subunit I (67 kDa), subunit II (51 kDa), and subunit III (20 kDa).
    Fructose 5-dehydrogenase (acceptor)
  • HY-P2957
    Hyaluronate lyase 37259-53-3
    Hyaluronate lyase can cleat hyaluronate (HA) and produce unsaturated disaccharides through a β-elimination reaction. The resulting disaccharides further trigger the downstream pathway and catalyze the next reaction. Hyaluronate lyase helps Streptococcus dysgalactiae subsp.equisimilis (SDSE) acquire nutrients from the host, causing bacterial pathogenicity.
    Hyaluronate lyase
製品番号 製品名 / Synonyms Application Reactivity