2. Metabolic Enzyme/Protease
  3. Endogenous Metabolite
  4. Osteocalcin (human)

Osteocalcin (human)  (Synonyms: Osteocalcin (1-49) (human))

Cat. No.: HY-P2588 Purity: 95.16%
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Osteocalcin (Osteocalcin (1-49)) (human) is a vitamin K-dependent bone specific protein. Osteocalcin (human) is chemotactic for several of the cell types frequently found at bone remodeling surfaces.

For research use only. We do not sell to patients.

Custom Peptide Synthesis

Osteocalcin (human)

Osteocalcin (human) Chemical Structure

CAS No. : 136461-80-8

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Based on 1 publication(s) in Google Scholar

Other Forms of Osteocalcin (human):

Osteocalcin (human) Related Antibodies

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Description

Osteocalcin (Osteocalcin (1-49)) (human) is a vitamin K-dependent bone specific protein. Osteocalcin (human) is chemotactic for several of the cell types frequently found at bone remodeling surfaces[1][2][3].

In Vitro

Osteocalcin (1 nM-1 μM) is chemotactic for breast cancer cells and osteoblast-like osteogenic sarcoma cells as well as monocytes, and causes their unidirectional migration[2].
Osteocalcin peptide contains 49 amino acids, with subsequent breakdown to fragments 1-19, 20-49, 20-43, 1-43, and 44-49 in the liver, kidney, and serum[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Osteocalcin (human) Related Antibodies
Molecular Weight

5929.44

Formula

C269H381N67O82S2
CAS No.
Appearance

Solid

Color

White to off-white

Sequence

Tyr-Leu-Tyr-Gln-Trp-Leu-Gly-Ala-Pro-Val-Pro-Tyr-Pro-Asp-Pro-Leu-{Gla}- Pro-Arg-Arg-{Gla}-Val-Cys-{Gla}-Leu-Asn-Pro-Asp-Cys-Asp-Glu-Leu-Ala-Asp-His-Ile-Gly-Phe-Gln-Glu-Ala-Tyr-Arg-Arg-Phe-Tyr-Gly-Pro-Val (Disulfide bridge:Cys23-Cys29)
Sequence Shortening

YLYQWLGAPVPYPDPL-{Gla}-PRR-{Gla}-VC-{Gla}-LNPDCDELADHIGFQEAYRRFYGPV (Disulfide bridge:Cys23-Cys29)
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Sealed storage, away from moisture

Powder -80°C 2 years
-20°C 1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (16.86 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 0.1686 mL 0.8432 mL 1.6865 mL
5 mM 0.0337 mL 0.1686 mL 0.3373 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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Volume (start)

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C2

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V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 0.1686 mL 0.8432 mL 1.6865 mL 4.2162 mL
5 mM 0.0337 mL 0.1686 mL 0.3373 mL 0.8432 mL
10 mM 0.0169 mL 0.0843 mL 0.1686 mL 0.4216 mL
15 mM 0.0112 mL 0.0562 mL 0.1124 mL 0.2811 mL
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Osteocalcin (human) Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Osteocalcin (human)136461-80-8Osteocalcin (1-49) (human)Endogenous MetaboliteBGPbreast cancermonocytesosteoblast-like osteogenic sarcomaMDA-MB-231Inhibitorinhibitorinhibit

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