2. Protein Tyrosine Kinase/RTK
  3. Insulin Receptor
  4. Peonidin 3-O-glucoside chloride

Peonidin 3-O-glucoside chloride is an agonist of the free fatty acid receptor FFAR1 and Glucokinase. Peonidin 3-O-glucoside chloride enhances insulin secretion of pancreatic beta cells and increases glucose uptake by liver cells. Peonidin 3-O-glucoside chloride activates FFAR1, promotes the phosphorylation of related proteins in the insulin secretion pathway, and increases the expression of FFAR1. In liver cells, Peonidin 3-O-glucoside chloride activates GK and regulates proteins associated with carbohydrate metabolism. Peonidin 3-O-glucoside chloride can be used in diabetes research.

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Peonidin 3-O-glucoside chloride

Peonidin 3-O-glucoside chloride Chemical Structure

CAS No. : 6906-39-4

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Based on 1 publication(s) in Google Scholar

Peonidin 3-O-glucoside chloride Related Antibodies

Top Publications Citing Use of Products

1 Publications Citing Use of MCE Peonidin 3-O-glucoside chloride

  • Biological Activity

  • Purity & Documentation

  • References

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Description

Peonidin 3-O-glucoside chloride is an agonist of the free fatty acid receptor FFAR1 and Glucokinase. Peonidin 3-O-glucoside chloride enhances insulin secretion of pancreatic beta cells and increases glucose uptake by liver cells. Peonidin 3-O-glucoside chloride activates FFAR1, promotes the phosphorylation of related proteins in the insulin secretion pathway, and increases the expression of FFAR1. In liver cells, Peonidin 3-O-glucoside chloride activates GK and regulates proteins associated with carbohydrate metabolism. Peonidin 3-O-glucoside chloride can be used in diabetes research[1][2].

In Vitro

Peonidin 3-O-glucoside (1-100 μM; 24 h) increases insulin secretion levels in INS-1E pancreatic β cells stimulated by glucose and increases the expression of FFAR1-dependent insulin secretion pathway-related proteins, such as phosphorylation of FFAR1, PLC, and PKD[1]. Peonidin 3-O-glucoside (100 μM; 24 h) increases glucose uptake in HepG2 hepatocytes, activated glucokinase (GK), and regulates proteins related to carbohydrate metabolism, such as increasing the phosphorylation level of AMP-activated protein kinase (AMPK) and reducing the expression of phosphoenolpyruvate carboxykinase (PEPCK)[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Peonidin 3-O-glucoside chloride Related Antibodies

Cell Viability Assay[1]

Cell Line: INS-1E pancreatic β-cells
Concentration: 1-100 μM
Incubation Time: 24 h
Result: The cells were treated with peonidin 3-O-glucoside at concentrations ranging from 1 to 100 μM for 24 h.
The results showed that compared with the untreated control group, the glucose-stimulated insulin secretion (GSIS) was enhanced by 18%-40%.
Western blot analysis indicated that the expression of proteins related to the FFAR1-dependent insulin secretory pathway, including FFAR1, PLC, and the phosphorylation of PKD, was increased.

Western Blot Analysis[1]

Cell Line: HepG2 hepatic cells
Concentration: 100 μM
Incubation Time: 24 h
Result: After treating HepG2 cells with 100 μM peonidin 3-O-glucoside for 24 h, the glucose uptake in these cells was increased by 19% compared to the untreated group.
Western blot analysis revealed that the phosphorylation of AMP-activated protein kinase (AMPK) was increased, and the expression of phosphoenolpyruvate carboxykinase (PEPCK) was reduced.
The activity of glucokinase (GK) was also activated, which indicated that peonidin 3-O-glucoside could modulate the carbohydrate metabolism in HepG2 cells.
Molecular Weight

498.86

Formula

C22H23ClO11
CAS No.
Appearance

Solid

Color

Brown to black

SMILES

OC1=CC(O)=CC2=C1C=C(O[C@@H]3O[C@H](CO)[C@@H](O)[C@H](O)[C@H]3O)C(C4=CC=C(O)C(OC)=C4)=[O+]2.[Cl-]
Structure Classification
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Solvent & Solubility
In Vitro: 

DMSO : 31.25 mg/mL (62.64 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

H2O : 5 mg/mL (10.02 mM; ultrasonic and warming and heat to 60°C)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.0046 mL 10.0229 mL 20.0457 mL
5 mM 0.4009 mL 2.0046 mL 4.0091 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
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Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: 98.02%

SDS (252 KB)

COA (259 KB) HNMR (276 KB) RP-HPLC (255 KB) MS (68 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O / DMSO 1 mM 2.0046 mL 10.0229 mL 20.0457 mL 50.1143 mL
5 mM 0.4009 mL 2.0046 mL 4.0091 mL 10.0229 mL
10 mM 0.2005 mL 1.0023 mL 2.0046 mL 5.0114 mL
DMSO 15 mM 0.1336 mL 0.6682 mL 1.3364 mL 3.3410 mL
20 mM 0.1002 mL 0.5011 mL 1.0023 mL 2.5057 mL
25 mM 0.0802 mL 0.4009 mL 0.8018 mL 2.0046 mL
30 mM 0.0668 mL 0.3341 mL 0.6682 mL 1.6705 mL
40 mM 0.0501 mL 0.2506 mL 0.5011 mL 1.2529 mL
50 mM 0.0401 mL 0.2005 mL 0.4009 mL 1.0023 mL
60 mM 0.0334 mL 0.1670 mL 0.3341 mL 0.8352 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Peonidin 3-O-glucoside chloride Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Peonidin 3-O-glucoside6906-39-4Insulin Receptoranthocyanininsulin secretagogueglucoseuptakeHepG2type-2 diabetesInhibitorinhibitorinhibit

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