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Cat. No.: HY-P2281

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Atrial natriuretic factor (1-28) (human, porcine)

Name: Atrial natriuretic factor (1-28) (human, porcine)
Brand: MedChemExpress
SKU: HY-P2281
Price: 653.00 USD
Availability: InStock
Rating: 5 (1 reviews)

(Synonyms: Atrial natriuretic peptide (1-28))

1 Cited Publications

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Based on 1 publication(s) in Google Scholar

Atrial natriuretic factor (1-28) (human, porcine) exhibits blood pressure lowering activity by increasing sodium and urine excretion. Atrial natriuretic factor (1-28) (human, porcine) inhibits the release of pituitary adrenocorticotropic hormone (ACTH) and beta-endorphin through inhibition of pro-opiomelanocortin (POMC) expression. Atrial natriuretic factor (1-28) (human, porcine) increases cGMP levels in RMIC cells with an IC₅₀ of 1.2 nM.

For research use only. We do not sell to patients.

CAS No.: 91917-63-4
Formula: C₁₂₇H₂₀₅N₄₅O₃₉S₃
Molecular Weight:3080.46

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Atrial natriuretic factor (1-28) (human, porcine) Chemical Structure

CAS No.: 91917-63-4

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

HY-P0003
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Biological Activity
- Description
- In Vitro
- In Vivo
Chemical Information
Publications (1)
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References
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Biological Activity

Description

All Endogenous Metabolite Isoforms :

In Vitro

ANF-(1-28) markedly increaseS guanosine 3',5'-cyclic monophosphate (cGMP) from 1.3 +/- 0.3 to 106 +/- 22 pmol cGMP/10(6) cells [50% effective dosage (ED₅₀) = 1.2 nM]^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

ANF-(1-28) (0.5 μg/kg/min) infusion attenuates the rise in plasma creatinine levels by approximately 50% on each day of the study^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 91917-63-4
Molecular Weight 3080.46
Formula C₁₂₇H₂₀₅N₄₅O₃₉S₃
Synonyms

Atrial natriuretic peptide (1-28)
Sequence

Ser-Leu-Arg-Arg-Ser-Ser-Cys-Phe-Gly-Gly-Arg-Met-Asp-Arg-Ile-Gly-Ala-Gln-Ser-Gly-Leu-Gly-Cys-Asn-Ser-Phe-Arg-Tyr
Sequence Shortening

SLRRSSCFGGRMDRIGAQSGLGCNSFRY
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Publications (1)

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Sci Adv

Transcriptional determinants of lipid mobilization in human adipocytes. [Abstract]

2024 Jan 5;10(1):eadi2689. PMID: 38170777

Purity & Documentation

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Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (260 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. B M Fontoura, et al. Atrial natriuretic factor receptors in cultured renomedullary interstitial cells. Am J Physiol. 1990 Apr;258(4 Pt 1):C692-9. [Content Brief]

[2]. T T Tan, et al. ANF(1-28) is a potent suppressor of pro-opiomelanocortin (POMC) mRNA but a weak inhibitor of beta EP-LI release from AtT-20 cells. J Endocrinol. 1994 Nov;143(2):R1-4. [Content Brief]

[3]. D M Pollock, et al. Beneficial effect of the ANF analog A68828 on recovery from ischemic acute renal failure. Ren Fail. 1992;14(2):141-6. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Keywords

Atrial natriuretic factor (1-28) (human, porcine)

1 Cited Publications

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Biological Activity
- Description
- In Vitro
- In Vivo
Chemical Information
Publications (1)
Purity & Documentation
References

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Atrial natriuretic factor (1-28) (human, porcine)

Publications Citing Use of MedChemExpress (MCE) Atrial natriuretic factor (1-28) (human, porcine)

All Endogenous Metabolite Isoforms