Rosabulin (Synonyms: STA 5312)

製品番号: HY-14934 純度: 98.72%: Data Sheet SDS COA 取扱説明書
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Rosabulin (STA 5312) is a potent and orally active microtubule inhibitor that inhibits microtubule assembly. Rosabulin has broad-spectrum anti-tumor activity.

商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。

Rosabulin 構造式

CAS 番号 : 501948-05-6

容量	価格（税別）	在庫状況	数量

>無料サンプル (0.1 - 0.2 mg)		今すぐ申し込む
>無料サンプル (0.1 - 0.2 mg)		今すぐ申し込む
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO ready for reconstitution	USD 341	在庫あり	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in DMSO	USD 341	在庫あり	Estimated Time of Arrival: December 31
Solid
5 mg	$310	在庫あり	Estimated Time of Arrival: December 31
10 mg	$465	在庫あり	Estimated Time of Arrival: December 31
25 mg	$837	在庫あり	Estimated Time of Arrival: December 31
50 mg	$1255	在庫あり	Estimated Time of Arrival: December 31
100 mg	$1800	在庫あり	Estimated Time of Arrival: December 31
200 mg		お問い合わせ
500 mg		お問い合わせ

or バルクお問い合わせ

* アイテムを追加する前、数量をご選択ください

This product is a controlled substance and not for sale in your territory.

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生物活性
純度とドキュメンテーション
参考文献
カスタマーレビュー

製品説明

Rosabulin (STA 5312) is a potent and orally active microtubule inhibitor that inhibits microtubule assembly. Rosabulin has broad-spectrum anti-tumor activity^[1].

Cellular Effect

Cell Line	Type	Value	Description	References
DU-145	IC₅₀	0.05 μM Compound: 5b	Cytotoxicity against human DU145 cells after 72 hrs by MTT assay Cytotoxicity against human DU145 cells after 72 hrs by MTT assay	[PMID: 18308566]
HL-60	IC₅₀	0.05 μM Compound: 5b	Cytotoxicity against human HL60 cells after 72 hrs by MTT assay Cytotoxicity against human HL60 cells after 72 hrs by MTT assay	[PMID: 18308566]
MDA-MB-435	IC₅₀	0.05 μM Compound: 5b	Cytotoxicity against human MDA435 cells after 72 hrs by MTT assay Cytotoxicity against human MDA435 cells after 72 hrs by MTT assay	[PMID: 18308566]
MES-SA	IC₅₀	0.01 μM Compound: 5b	Cytotoxicity against human MESSA cells after 72 hrs by MTT assay Cytotoxicity against human MESSA cells after 72 hrs by MTT assay	[PMID: 18308566]
MES-SA/Dx5	IC₅₀	0.05 μM Compound: 5b	Cytotoxicity against human MESSA/DX5 cells after 72 hrs by MTT assay Cytotoxicity against human MESSA/DX5 cells after 72 hrs by MTT assay	[PMID: 18308566]
P388	IC₅₀	0.01 μM Compound: 5b	Cytotoxicity against mouse P388 cells after 72 hrs by MTT assay Cytotoxicity against mouse P388 cells after 72 hrs by MTT assay	[PMID: 18308566]

体外実験

Rosabulin (STA 5312) demonstrates substantial anti-proliferative activity against a wide range of cancer cell linesin vitro, including hematologic and solid tumor cell lines of various origins (e.g. leukemia, lymphoma, breast, colon, uterine), with IC₅₀ values extending down into the nanomolar range. Cell lines with multi-drug resistant (MDR) phenotypes are similarly sensitive to Rosabulin. The mechanism of action for Rosabulin is inhibition of microtubule assembly and subsequent arrest of the cell cycle^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

体内実験

When dosed orally or intravenously, Rosabulin (STA 5312) has shown in vivo activity in several murine tumors as well as human tumor xenograft models, including drug resistant tumors^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

臨床実験

分子量

400.45

分子式

C₂₂H₁₆N₄O₂S

CAS 番号

501948-05-6

Appearance

Solid

Color

Light yellow to green yellow

SMILES

O=C(NC1=CC(C)=NS1)C(C2=C3C=CC=CN3C(CC4=CC=C(C#N)C=C4)=C2)=O

輸送条件

Room temperature in continental US; may vary elsewhere.

保管条件

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

溶剤 & 溶解度

体外:

DMSO : 50 mg/mL (124.86 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.4972 mL	12.4860 mL	24.9719 mL
5 mM	0.4994 mL	2.4972 mL	4.9944 mL
10 mM	0.2497 mL	1.2486 mL	2.4972 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

一般には略語で表示されます：C₁V₁ = C₂V₂

濃度 _（開始）

体積 _（開始）

濃度 _（終了）

体積 _（終了）

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

純度とドキュメンテーション

純度: 98.72%

Select Batch:

データシート (279 KB) SDS (252 KB)

COA (261 KB) HNMR (173 KB) RP-HPLC (472 KB) MS (100 KB)

取扱説明書 (2659 KB)

参考文献

[1]. Keizo Koya,et al. STA-5312, a novel tubulin inhibitor, demonstrates the anti-cancer activity against chemotherapy-resistant cancers. Cancer Res, Volume 45, 2004.

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	2.4972 mL	12.4860 mL	24.9719 mL	62.4298 mL
	5 mM	0.4994 mL	2.4972 mL	4.9944 mL	12.4860 mL
	10 mM	0.2497 mL	1.2486 mL	2.4972 mL	6.2430 mL
	15 mM	0.1665 mL	0.8324 mL	1.6648 mL	4.1620 mL
	20 mM	0.1249 mL	0.6243 mL	1.2486 mL	3.1215 mL
	25 mM	0.0999 mL	0.4994 mL	0.9989 mL	2.4972 mL
	30 mM	0.0832 mL	0.4162 mL	0.8324 mL	2.0810 mL
	40 mM	0.0624 mL	0.3121 mL	0.6243 mL	1.5607 mL
	50 mM	0.0499 mL	0.2497 mL	0.4994 mL	1.2486 mL
	60 mM	0.0416 mL	0.2081 mL	0.4162 mL	1.0405 mL
	80 mM	0.0312 mL	0.1561 mL	0.3121 mL	0.7804 mL
	100 mM	0.0250 mL	0.1249 mL	0.2497 mL	0.6243 mL

Rosabulin Related Classifications

Molarity Calculator
Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

質量		濃度		体積		分子量 *
	=		×		×

The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

一般には略語で表示されます：C₁V₁ = C₂V₂

濃度 _（開始）	×	体積 _（開始）	=	濃度 _（終了）	×	体積 _（終了）
	×		=		×
C1		V1		C2		V2

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Rosabulin501948-05-6STA 5312STA5312STA-5312Microtubule/Tubulinhematologicsolidtumorsanti-tumormicrotubuleassemblyInhibitorinhibitorinhibit

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