2. Antibody-drug Conjugate/ADC Related
  3. ADC Payload
  4. SGD-1882

SGD-1882  (Synonyms: PBD dimer)

製品番号: HY-101127 純度: 95.29%
COA 取扱説明書 Technical Support

SGD-1882 is a cytotoxic, DNA minor-groove crosslinking agent pyrrolobenzodiazepine (PBD) dimer, acting as the payload for ADCs.

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SGD-1882

SGD-1882 構造式

CAS 番号 : 1222490-34-7

容量 価格（税別） 在庫状況 数量
1 mg $900 在庫あり
5 mg $2250 お問い合わせ
10 mg $3600 お問い合わせ
50 mg   お問い合わせ  
100 mg   お問い合わせ  

* アイテムを追加する前、数量をご選択ください

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SGD-1882 関連抗体

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ADC Payload アイソフォーム固有の製品をすべて表示:

すべてのアイソフォームを表示
Auristatin Calicheamicins Camptothecins Daunorubicins/Doxorubicins Duocarmycins Maytansinoids Pyrrolobenzodiazepines Traditional Cytotoxic Agents

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製品説明

SGD-1882 is a cytotoxic, DNA minor-groove crosslinking agent pyrrolobenzodiazepine (PBD) dimer, acting as the payload for ADCs.

体外実験

SGD-1882 is the cytotoxic payload undergoing clinical evaluation for anti-CD33 and anti-CD70 conjugates[1]. SGD-1882 is not an MDR1 substrate, and SGN-CD33A is conjugated to the SGD-1882. SGN-CD33A can kill MDR1 expressing CD33 positive AML patient samples and is currently in Phase I[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

SGD-1882 関連抗体
分子量

725.79

分子式

C42H39N5O7
CAS 番号
Appearance

Solid

Color

Light yellow to yellow

SMILES

O=C(C1=CC(OC)=C(OCCCOC(C=C(N=C[C@@]2([H])N(C=C(C3=CC=C(N)C=C3)C2)C4=O)C4=C5)=C5OC)C=C1N=C6)N7[C@@]6([H])CC(C8=CC=C(OC)C=C8)=C7
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件
Powder -20°C 3 years
In solvent -80°C 6 months
  -20°C 1 month
溶剤 & 溶解度
体外: 

DMSO : 100 mg/mL (137.78 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.3778 mL 6.8890 mL 13.7781 mL
5 mM 0.2756 mL 1.3778 mL 2.7556 mL
10 mM 0.1378 mL 0.6889 mL 1.3778 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

一般には略語で表示されます：C1V1 = C2V2

濃度 （開始）

C1

×
体積 （開始）

V1

=
濃度 （終了）

C2

×
体積 （終了）

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

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(per animal)

g

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(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
純度とドキュメンテーション
参考文献

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.3778 mL 6.8890 mL 13.7781 mL 34.4452 mL
5 mM 0.2756 mL 1.3778 mL 2.7556 mL 6.8890 mL
10 mM 0.1378 mL 0.6889 mL 1.3778 mL 3.4445 mL
15 mM 0.0919 mL 0.4593 mL 0.9185 mL 2.2963 mL
20 mM 0.0689 mL 0.3445 mL 0.6889 mL 1.7223 mL
25 mM 0.0551 mL 0.2756 mL 0.5511 mL 1.3778 mL
30 mM 0.0459 mL 0.2296 mL 0.4593 mL 1.1482 mL
40 mM 0.0344 mL 0.1722 mL 0.3445 mL 0.8611 mL
50 mM 0.0276 mL 0.1378 mL 0.2756 mL 0.6889 mL
60 mM 0.0230 mL 0.1148 mL 0.2296 mL 0.5741 mL
80 mM 0.0172 mL 0.0861 mL 0.1722 mL 0.4306 mL
100 mM 0.0138 mL 0.0689 mL 0.1378 mL 0.3445 mL
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SGD-1882 Related Classifications

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

質量   濃度   体積   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

一般には略語で表示されます：C1V1 = C2V2

濃度 （開始） × 体積 （開始） = 濃度 （終了） × 体積 （終了）
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

SGD-18821222490-34-7PBD dimerSGD1882SGD 1882ADC PayloadADC CytotoxinInhibitorinhibitorinhibit

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製品番号:
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