2. 天然物
  3. Disease Research Fields Plants Terpenoids
  4. Other Diseases other families Other Monoterpenes
  5. Sabinene

サビネン  (Synonyms: Sabinene)

製品番号: HY-108943 純度: 79.94%
COA 取扱説明書 Technical Support

Sabinene is an naturally occurring bicyclic monoterpene which can be used as flavorings, perfume additives, fine chemicals, and advanced biofuels. Sabinene is also an orally active compound to attenuates skeletal muscle atrophy and regulates ROS-mediated MAPK/MuRF-1 pathways.

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Sabinene

サビネン 構造式

CAS 番号 : 3387-41-5

容量 価格（税別） 在庫状況 数量
Liquid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
 USD 72 在庫あり
Solution
10 mM * 1 mL in DMSO USD 72 在庫あり
Liquid
100 mg $66 在庫あり
500 mg $132 在庫あり
1 g   お問い合わせ  
5 g   お問い合わせ  

* アイテムを追加する前、数量をご選択ください

This product is a controlled substance and not for sale in your territory.

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Based on 2 publication(s) in Google Scholar

サビネン 関連抗体

Top Publications Citing Use of Products

  • 生物活性

  • 純度とドキュメンテーション

  • 参考文献

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製品説明

Sabinene is an naturally occurring bicyclic monoterpene which can be used as flavorings, perfume additives, fine chemicals, and advanced biofuels. Sabinene is also an orally active compound to attenuates skeletal muscle atrophy and regulates ROS-mediated MAPK/MuRF-1 pathways[1][2].

体外実験

Sabinene (10-300 μM; 18 h) induces predominant recovery of reductions of myotube diameters under starvation[2].
Sabinene (300 μM; 18 h) diminishes the elevated E3 ubiquitin ligase muscle ring-finger protein-1 (MuRF-1) expression and p38 mitogen-activated protein kinase (MAPK), and attenuates extracellular signal-regulated kinase1/2 (ERK1/2) phosphorylations in starved myotubes[2].
Sabinene (300 μM; 18 h) decreases the increased level of reactive oxygen species (ROS) in myotubes under starvation[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

サビネン 関連抗体

Cell Cytotoxicity Assay[2]

Cell Line: IL-6 myoblasts
Concentration: 300 μM
Incubation Time: 18 and 48 hours
Result: Failed to affect the viability of IL-6 myoblasts after 48 h incubation and recovered more than 50% of starvation-induced myoblast atrophy after 18 h.

Western Blot Analysis[2]

Cell Line: IL-6 myoblasts
Concentration: 300 μM
Incubation Time: 18 hours
Result: Attenuated muscle atrophy-related signaling proteins phosphorylation in starved myotubes.
体内実験

Sabinene (6.4 mg/kg; p.o.; once daily; during the fasting for 2 d) attenuates skeletal muscle atrophy by regulating the activation mechanism of ROS-mediated MAPK/MuRF-1 pathways in starved myotubes, probably leading to the reverse of reduced muscle fiber size in fasted rats[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Fasted animal model in rat[2]
Dosage: 6.4 mg/kg
Administration: Oral gavage; once daily; during the fasting for 2 days
Result: Reduced the levels of muscle fiber atrophy and MuRF-1 expression in gastrocnemius from fasted rats.
分子量

136.24

分子式

C10H16
CAS 番号
Appearance

Liquid (Density: 0.842 g/cm3)

Color

Colorless to light yellow

SMILES

CC(C12CCC(C1C2)=C)C
Structure Classification
Initial Source
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件
Pure form -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
溶剤 & 溶解度
体外: 

DMSO : 100 mg/mL (734.00 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 7.3400 mL 36.6999 mL 73.3999 mL
5 mM 1.4680 mL 7.3400 mL 14.6800 mL
10 mM 0.7340 mL 3.6700 mL 7.3400 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

一般には略語で表示されます：C1V1 = C2V2

濃度 （開始）

C1

×
体積 （開始）

V1

=
濃度 （終了）

C2

×
体積 （終了）

V2

体内:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  10% DMSO    90% Corn Oil

    Solubility: ≥ 5 mg/mL (36.70 mM); Clear solution

    This protocol yields a clear solution of ≥ 5 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.

    Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (50.0 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
%
DMSO +
% 
+
%
Tween-80 +
%
Saline
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Calculation results:
Working solution concentration: mg/mL
Method for preparing stock solution: mg drug dissolved in μL  DMSO (Stock solution concentration: mg/mL).
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).
Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.
 If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
純度とドキュメンテーション
参考文献

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 7.3400 mL 36.6999 mL 73.3999 mL 183.4997 mL
5 mM 1.4680 mL 7.3400 mL 14.6800 mL 36.6999 mL
10 mM 0.7340 mL 3.6700 mL 7.3400 mL 18.3500 mL
15 mM 0.4893 mL 2.4467 mL 4.8933 mL 12.2333 mL
20 mM 0.3670 mL 1.8350 mL 3.6700 mL 9.1750 mL
25 mM 0.2936 mL 1.4680 mL 2.9360 mL 7.3400 mL
30 mM 0.2447 mL 1.2233 mL 2.4467 mL 6.1167 mL
40 mM 0.1835 mL 0.9175 mL 1.8350 mL 4.5875 mL
50 mM 0.1468 mL 0.7340 mL 1.4680 mL 3.6700 mL
60 mM 0.1223 mL 0.6117 mL 1.2233 mL 3.0583 mL
80 mM 0.0917 mL 0.4587 mL 0.9175 mL 2.2937 mL
100 mM 0.0734 mL 0.3670 mL 0.7340 mL 1.8350 mL
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Sabinene Related Classifications

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

質量   濃度   体積   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

一般には略語で表示されます：C1V1 = C2V2

濃度 （開始） × 体積 （開始） = 濃度 （終了） × 体積 （終了）
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Sabinene3387-41-5Othersflavoringsperfume additivesfine chemicalsadvanced biofuelbicyclic monoterpeneChrysanthemum borealeMakino essential oilskeletal muscle atrophyL6 cellsInhibitorinhibitorinhibit

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