2. Metabolic Enzyme/Protease NF-κB Immunology/Inflammation Neuronal Signaling
  3. Mitochondrial Metabolism Reactive Oxygen Species (ROS) Amyloid-β
  4. Succinyl phosphonate

Succinyl phosphonate is a α-Ketoglutarate Dehydrogenase Complex (KGDHC) modulator with neuroprotective activity. Succinyl phosphonate protects this complex, reduces cellular succinyl-CoA concentration, downregulates protein succinylation levels, and inhibits the activity of the α-ketoglutarate dehydrogenase complex. Succinyl phosphonate corrects hypoxic or ethanol-induced behavioral impairments, modulates exploratory behavior and emotional stress responses, and improves hypoxia tolerance. Succinyl phosphonate reduces glutamate excitotoxicity, restores the activity of the α-ketoglutarate dehydrogenase complex, reverses the changes in glutamate dehydrogenase and glutamine synthetase activities induced by β-amyloid (Amyloid-β), modulates cognitive function, and prevents β-amyloid-induced neuronal damage. Succinyl phosphonate improves microglial senescence, alleviates neuroinflammation, reactive oxygen species (ROS) production, lipid peroxidation, and the expression of proinflammatory cytokines. Succinyl phosphonate can be used in the research of Alzheimer's disease, aging-related neuroinflammation, and Parkinson's disease.

At equivalent molar concentrations, both the salt and free forms of a compound exhibit comparable biological activity. Nevertheless, the salt form (Succinyl phosphonate trisodium salt) usually boasts enhanced water solubility and stability.

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CAS No. : 26647-82-5

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Succinyl phosphonate Related Antibodies

Top Publications Citing Use of Products

    Succinyl phosphonate purchased from MedChemExpress. Usage Cited in: J Cell Sci. 2026 Mar 16:jcs.264420.

    Bar graphs (depicting mean±s.d. together with the individual data points) of neuronal viability determined after exposure to zero-Mg2+-induced excitotoxicity of untreated cultures (ctrl, n=45), cultures pretreated for 36 to 48 h with Succinyl phosphonate trisodium salt (SP, 200 µM) (n=36), with TH (n=42) or with both compounds (TH+SP, n=41) (from three independent culture preparations).

    Succinyl phosphonate purchased from MedChemExpress. Usage Cited in: J Cell Sci. 2026 Mar 16:jcs.264420.

    Depiction of representative voltage responses to application of 3 µM and 10 µM glutamate of control neurons, Succinyl phosphonate trisodium salt (SP)-treated neurons and TH-treated neurons. Responses were characterized by triggering of or increase in action potential discharge, and at 10 µM glutamate, by a transition into depolarisation block, which manifests itself in a cessation of discharge activity during sustained depolarization. Action potentials are truncated at −10 mV.

    Succinyl phosphonate purchased from MedChemExpress. Usage Cited in: Clin Rheumatol. 2025 Nov 20.  [Abstract]

    ZNF76 activity quantified upon Succinyl phosphonate trisodium salt (SP) (50 μM) treatment. The results showed that the application of the OGDH inhibitor SP significantly reduced the binding of ZNF76 to the promoter region of the DRP1 gene.

    Succinyl phosphonate purchased from MedChemExpress. Usage Cited in: Research Square Preprint. 2022.

    Proliferation assay of EPCs treated with vehicle or various concentration of Succinyl phosphonate trisodium salt (SP, 5-80 μM; 3 days) under normoxia (n = 6).

    Succinyl phosphonate purchased from MedChemExpress. Usage Cited in: Research Square Preprint. 2022.

    qRT-PCR showed higher expression of EPC stemness markers in the presence of 20 uM Succinyl phosphonate trisodium salt (SP) than with vehicle control under normoxia (n=5).

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    • References

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    Description

    Succinyl phosphonate is a α-Ketoglutarate Dehydrogenase Complex (KGDHC) modulator with neuroprotective activity. Succinyl phosphonate protects this complex, reduces cellular succinyl-CoA concentration, downregulates protein succinylation levels, and inhibits the activity of the α-ketoglutarate dehydrogenase complex. Succinyl phosphonate corrects hypoxic or ethanol-induced behavioral impairments, modulates exploratory behavior and emotional stress responses, and improves hypoxia tolerance. Succinyl phosphonate reduces glutamate excitotoxicity, restores the activity of the α-ketoglutarate dehydrogenase complex, reverses the changes in glutamate dehydrogenase and glutamine synthetase activities induced by β-amyloid (Amyloid-β), modulates cognitive function, and prevents β-amyloid-induced neuronal damage. Succinyl phosphonate improves microglial senescence, alleviates neuroinflammation, reactive oxygen species (ROS) production, lipid peroxidation, and the expression of proinflammatory cytokines. Succinyl phosphonate can be used in the research of Alzheimer's disease, aging-related neuroinflammation, and Parkinson's disease[1][2][3][4].

    In Vitro

    Succinyl phosphonate (10 μM; 72 h) reduces succinylation levels and succinyl-CoA concentrations, mitigates LPS (HY-D1056)-induced reactive oxygen species production, lipid accumulation, lipid peroxidation, and pro-inflammatory cytokine expression in BV2 cells and primary mouse microglia, and reduces senescence in VP-16 (HY-13629)-induced aged BV2 cells[3].
    Succinyl phosphonate upregulates active OGDHC quantity in cultured neurons, but this upregulation is impaired by co-treatment with ethanol[4].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    Succinyl phosphonate Related Antibodies
    In Vivo

    Succinyl phosphonate (intranasal; single dose) pretreatment protects pregnancy-sensitized rats from hypoxia and ethanol-induced behavioral impairment, including normalizing post-hypoxia horizontal moving activity and increasing hypoxia resistance in sensitive animals[1].
    Succinyl phosphonate (10 nM; intra-CA1; 30 minutes after first Aβ25-35 injection) can block the damaging effects induced by Aβ and neuronal damage, improve the spatial learning and memory abilities of rats, and reverse the decrease in α-KGDHC enzyme activity[2].
    Succinyl phosphonate (1 mg/kg; i.c.v.; single injection) reduces LPS (HY-D1056)-induced hippocampal mitochondrial protein succinylation, including succinylation of SDHA and ECHA, in male C57BL/6J mice[3].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    Animal Model: Wistar rats (adult male, 230-250 g, Alzheimer’s disease model via bilateral microinjection of aggregated amyloid-beta25-35 into dorsal CA1 area for 4 consecutive days)[2]
    Dosage: 10 nM
    Administration: intra-CA1; single dose; 30 minutes after first Aβ25-35 injection
    Result: Prevented Aβ25-35-induced spatial learning deficits, as shown by significantly reduced AUC of escape latencies and improved escape latencies in specific trials.
    Reversed Aβ25-35-induced spatial memory deficits, with time spent in the MWM target quadrant not differing from controls.
    Restored hippocampal α-KGDHC activity to control levels.
    Reduced elevated GDH activity to control levels.
    Prevented the Aβ-induced reduction in GS activity.
    Reduced Aβ-induced neuronal damage in the hippocampal CA1, CA3, and DG regions, with significantly more surviving neurons compared to the Aβ-only group.
    Animal Model: LPS-induced C57BL/6J (2-4 month-old male, wild type)[3]
    Dosage: 1 mg/kg
    Administration: i.c.v.; single injection
    Result: Reversed the LPS-induced increase in hippocampal mitochondrial protein succinylation, restoring it to near control levels.
    Significantly reduced the LPS-elevated succinylation levels of succinate dehydrogenase (SDHA) and trifunctional enzyme subunit alpha (ECHA) in mouse hippocampus.
    Molecular Weight

    182.07

    Formula

    C4H7O6P
    CAS No.
    Appearance

    Oil

    Color

    Colorless to light yellow

    SMILES

    O=C(O)CCC(P(O)(O)=O)=O
    Structure Classification
    Initial Source
    Shipping

    Room temperature in continental US; may vary elsewhere.
    Storage
    Pure form -20°C 3 years
    4°C 2 years
    In solvent -80°C 6 months
    -20°C 1 month
    Purity & Documentation
    References
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    Succinyl phosphonate Related Classifications

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    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    Succinyl phosphonate26647-82-5Mitochondrial MetabolismReactive Oxygen Species (ROS)Amyloid-ββ-amyloid peptideAβAbetaprimary mouse microgliaprotein succinylationglutamine synthetasemale Wistar ratsBV2 cellsglutamate dehydrogenaseamyloid-betamale C57BL/6J micesuccinyl-CoA2-oxoglutarate dehydrogenase complexInhibitorinhibitorinhibit

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