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  3. Succinyl phosphonate trisodium salt

Succinyl phosphonate trisodium salt 

Cat. No.: HY-12688A Purity: ≥98.0%
COA Handling Instructions

Succinyl phosphonate trisodium salt is an α-ketoglutarate dehydrogenase (KGDHC) inhibitor, effective inhibits (KGDHC) in muscle, bacterial, brain, and cultured human fibroblasts. Succinyl phosphonate trisodium salt is an 2-oxoglutarate dehydrogenase (OGDH) inhibitor, impairs viability of cancer cells in a cell-specific metabolism-dependent manner. Succinyl phosphonate trisodium salt inhibits the glutamate-induced ROS production in glutamate-stimulated hippocampal neurons in situ.

For research use only. We do not sell to patients.

Succinyl phosphonate trisodium salt Chemical Structure

Succinyl phosphonate trisodium salt Chemical Structure

CAS No. : 864167-45-3

Size Price Stock Quantity
5 mg USD 420 In-stock
10 mg USD 600 In-stock
50 mg   Get quote  
100 mg   Get quote  

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Customer Review

Based on 11 publication(s) in Google Scholar

Other Forms of Succinyl phosphonate trisodium salt:

Top Publications Citing Use of Products
  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

Succinyl phosphonate trisodium salt is an α-ketoglutarate dehydrogenase (KGDHC) inhibitor, effective inhibits (KGDHC) in muscle, bacterial, brain, and cultured human fibroblasts[1][4]. Succinyl phosphonate trisodium salt is an 2-oxoglutarate dehydrogenase (OGDH) inhibitor, impairs viability of cancer cells in a cell-specific metabolism-dependent manner[2]. Succinyl phosphonate trisodium salt inhibits the glutamate-induced ROS production in glutamate-stimulated hippocampal neurons in situ[3].

IC50 & Target

α-ketoglutarate dehydrogenase; 2-oxoglutarate dehydrogenase[1][4]; ROS production[3]

In Vivo

Succinyl phosphonate trisodium salt (0.02 mmol/kg, nasal administration) inhibits 2-oxogglutarate dehydrogenase in rats to reduce the low valley tathione redoxic state, and increases anxiety and interfered with stress adaption[5].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

248.01

Formula

C4H4Na3O6P

CAS No.
Appearance

Solid

Color

White to light yellow

SMILES

O=C(O[Na])CCC(P(O[Na])(O[Na])=O)=O

Structure Classification
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

H2O : 50 mg/mL (201.60 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 4.0321 mL 20.1605 mL 40.3210 mL
5 mM 0.8064 mL 4.0321 mL 8.0642 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo:

For the following dissolution methods, please prepare the working solution directly. It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  PBS

    Solubility: 25 mg/mL (100.80 mM); Clear solution; Need ultrasonic

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation

Purity: ≥98.0%

References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 4.0321 mL 20.1605 mL 40.3210 mL 100.8024 mL
5 mM 0.8064 mL 4.0321 mL 8.0642 mL 20.1605 mL
10 mM 0.4032 mL 2.0160 mL 4.0321 mL 10.0802 mL
15 mM 0.2688 mL 1.3440 mL 2.6881 mL 6.7202 mL
20 mM 0.2016 mL 1.0080 mL 2.0160 mL 5.0401 mL
25 mM 0.1613 mL 0.8064 mL 1.6128 mL 4.0321 mL
30 mM 0.1344 mL 0.6720 mL 1.3440 mL 3.3601 mL
40 mM 0.1008 mL 0.5040 mL 1.0080 mL 2.5201 mL
50 mM 0.0806 mL 0.4032 mL 0.8064 mL 2.0160 mL
60 mM 0.0672 mL 0.3360 mL 0.6720 mL 1.6800 mL
80 mM 0.0504 mL 0.2520 mL 0.5040 mL 1.2600 mL
100 mM 0.0403 mL 0.2016 mL 0.4032 mL 1.0080 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Succinyl phosphonate trisodium salt Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Succinyl phosphonate trisodium salt
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