1. Metabolic Enzyme/Protease
    NF-κB
    Immunology/Inflammation
  2. Endogenous Metabolite
    Reactive Oxygen Species
  3. Succinyl phosphonate trisodium salt

Succinyl phosphonate trisodium salt 

Cat. No.: HY-12688A Purity: >98.0%
Handling Instructions

Succinyl phosphonate trisodium salt is an α-ketoglutarate dehydrogenase (KGDHC) inhibitor, effective inhibits (KGDHC) in muscle, bacterial, brain, and cultured human fibroblasts. Succinyl phosphonate trisodium salt is an 2-oxoglutarate dehydrogenase (OGDH) inhibitor, impairs viability of cancer cells in a cell-specific metabolism-dependent manner. Succinyl phosphonate trisodium salt inhibits the glutamate-induced ROS production in glutamate-stimulated hippocampal neurons in situ.

For research use only. We do not sell to patients.

Succinyl phosphonate trisodium salt Chemical Structure

Succinyl phosphonate trisodium salt Chemical Structure

CAS No. : 864167-45-3

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5 mg USD 420 In-stock
Estimated Time of Arrival: December 31
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Customer Review

Based on 6 publication(s) in Google Scholar

Other Forms of Succinyl phosphonate trisodium salt:

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Description

Succinyl phosphonate trisodium salt is an α-ketoglutarate dehydrogenase (KGDHC) inhibitor, effective inhibits (KGDHC) in muscle, bacterial, brain, and cultured human fibroblasts[1][4]. Succinyl phosphonate trisodium salt is an 2-oxoglutarate dehydrogenase (OGDH) inhibitor, impairs viability of cancer cells in a cell-specific metabolism-dependent manner[2]. Succinyl phosphonate trisodium salt inhibits the glutamate-induced ROS production in glutamate-stimulated hippocampal neurons in situ[3].

IC50 & Target

α-ketoglutarate dehydrogenase; 2-oxoglutarate dehydrogenase[1][4]; ROS production[3]

Molecular Weight

248.01

Formula

C₄H₄Na₃O₆P

CAS No.

864167-45-3

SMILES

O=C(O[Na])CCC(P(O[Na])(O[Na])=O)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

H2O : 125 mg/mL (504.01 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 4.0321 mL 20.1605 mL 40.3210 mL
5 mM 0.8064 mL 4.0321 mL 8.0642 mL
10 mM 0.4032 mL 2.0160 mL 4.0321 mL
*Please refer to the solubility information to select the appropriate solvent.
References

Purity: >98.0%

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Keywords:

Succinyl phosphonate trisodiumEndogenous MetaboliteReactive Oxygen SpeciesInhibitorinhibitorinhibit

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Succinyl phosphonate trisodium salt
Cat. No.:
HY-12688A
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