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Succinyl phosphonate

14 Cited Publications
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Based on 14 publication(s) in Google Scholar

Succinyl phosphonate is a α-Ketoglutarate Dehydrogenase Complex (KGDHC) modulator with neuroprotective activity. Succinyl phosphonate protects this complex, reduces cellular succinyl-CoA concentration, downregulates protein succinylation levels, and inhibits the activity of the α-ketoglutarate dehydrogenase complex. Succinyl phosphonate corrects hypoxic or ethanol-induced behavioral impairments, modulates exploratory behavior and emotional stress responses, and improves hypoxia tolerance. Succinyl phosphonate reduces glutamate excitotoxicity, restores the activity of the α-ketoglutarate dehydrogenase complex, reverses the changes in glutamate dehydrogenase and glutamine synthetase activities induced by β-amyloid (Amyloid-β), modulates cognitive function, and prevents β-amyloid-induced neuronal damage. Succinyl phosphonate improves microglial senescence, alleviates neuroinflammation, reactive oxygen species (ROS) production, lipid peroxidation, and the expression of proinflammatory cytokines. Succinyl phosphonate can be used in the research of Alzheimer's disease, aging-related neuroinflammation, and Parkinson's disease.

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  • CAS No.: 26647-82-5
  • Formula: C4H7O6P
  • Molecular Weight:182.07
  • Storage:
    Pure form   -20°C, 3 years , 4°C, 2 years ; In solvent   -80°C, 6 months , -20°C, 1 month
  • Succinyl phosphonate Chemical Structure
    Succinyl phosphonate Chemical Structure
  • Experimental Validation Results for Succinyl phosphonate
  • Experimental Validation Results for Succinyl phosphonate
  • Experimental Validation Results for Succinyl phosphonate
  • Experimental Validation Results for Succinyl phosphonate
  • Experimental Validation Results for Succinyl phosphonate
CAS No.: 26647-82-5
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IPCell Proliferation/Viability AssayBio/Physico-chemical AssayRT-PCR
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  • Bio/Physico-chemical Assay
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  • Cell Proliferation/Viability Assay
  • RT-PCR
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  • Succinyl phosphonate Chemical Structure
    Succinyl phosphonate Chemical Structure
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    Succinyl phosphonate purchased from MedChemExpress. Usage Cited in: J Cell Sci. 2026 Mar 16:jcs.264420. [Abstract]

    Customer Validation
     Bar graphs (depicting mean±s.d. together with the individual data points) of neuronal viability determined after exposure to zero-Mg2+-induced excitotoxicity of untreated cultures (ctrl, n=45), cultures pretreated for 36 to 48 h with Succinyl phosphonate trisodium salt (SP, 200 µM) (n=36), with TH (n=42) or with both compounds (TH+SP, n=41) (from three independent culture preparations).

  • 1/16

    Succinyl phosphonate purchased from MedChemExpress. Usage Cited in: J Cell Sci. 2026 Mar 16:jcs.264420. [Abstract]

    Customer Validation
     Depiction of representative voltage responses to application of 3 µM and 10 µM glutamate of control neurons, Succinyl phosphonate trisodium salt (SP)-treated neurons and TH-treated neurons. Responses were characterized by triggering of or increase in action potential discharge, and at 10 µM glutamate, by a transition into depolarisation block, which manifests itself in a cessation of discharge activity during sustained depolarization. Action potentials are truncated at −10 mV.

  • 1/16

    Succinyl phosphonate purchased from MedChemExpress. Usage Cited in: Clin Rheumatol. 2025 Nov 20. [Abstract]

    Customer Validation
     ZNF76 activity quantified upon Succinyl phosphonate trisodium salt (SP) (50 μM) treatment. The results showed that the application of the OGDH inhibitor SP significantly reduced the binding of ZNF76 to the promoter region of the DRP1 gene.

  • 1/16

    Succinyl phosphonate purchased from MedChemExpress. Usage Cited in: Research Square Preprint. 2022.

    Customer Validation
     Proliferation assay of EPCs treated with vehicle or various concentration of Succinyl phosphonate trisodium salt (SP, 5-80 μM; 3 days) under normoxia (n = 6).

  • 1/16

    Succinyl phosphonate purchased from MedChemExpress. Usage Cited in: Research Square Preprint. 2022.

    Customer Validation
     qRT-PCR showed higher expression of EPC stemness markers in the presence of 20 uM Succinyl phosphonate trisodium salt (SP) than with vehicle control under normoxia (n=5).

  • Succinyl phosphonate