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Succinyl phosphonate 

Cat. No.: HY-12688
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Succinyl phosphonate is an inhibitor of the α-ketoglutarate dehydrogenase.

For research use only. We do not sell to patients.

Succinyl phosphonate Chemical Structure

Succinyl phosphonate Chemical Structure

CAS No. : 26647-82-5

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Succinyl phosphonate is an inhibitor of the α-ketoglutarate dehydrogenase.

In Vitro

Succinyl phosphonate is an α-Ketoglutarate phosphoanalogue. It is found to be an effective inhibitor of α-ketoglutarate oxidative decarboxylation, catalyzed by both muscle and bacterial α-ketoglutarate dehydrogenase complexes, as well as muscle α-ketoglutarate dehydrogenase[1]. At a concentration of 0.01 mM, succinyl phosphonate completely inhibits isolated brain KGDHC even in the presence of a 200-fold higher concentration of its substrate. In cultured human fibroblasts, 0.01 mM succinyl phosphonate produced 70% inhibition of α-ketoglutarate dehydrogenase complex. DESP and TESP are also inhibitory in the cell system, but only after preincubation, suggesting the release of their charged groups by cellular esterases[2]. Succinyl phosphonate inhibits 2-Oxoglutarate dehydrogenase , the first rate-limiting component of the mitochondrial multi-enzyme complex of oxidative decarboxylation of 2-oxoglutarate, in a highly selective and efficient manner[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight









Room temperature in continental US; may vary elsewhere.

Pure form -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

H2O : ≥ 50 mg/mL (274.62 mM)

*"≥" means soluble, but saturation unknown.

Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 5.4924 mL 27.4620 mL 54.9239 mL
5 mM 1.0985 mL 5.4924 mL 10.9848 mL
10 mM 0.5492 mL 2.7462 mL 5.4924 mL
*Please refer to the solubility information to select the appropriate solvent.
Cell Assay

MTT assay is employed to test cellular viability. Serial dilutions of succinyl phosphonate (0.01-20 mM) are added to cells in fresh culture media. During the medium exchange before the succinyl phosphonate addition, glioblastoma cells are brought to DMEM with 1 g/L glucose, 1 mM pyruvate and 2 mM glutamax. The influence of succinyl phosphonate in minimal medium is studied in the earlier employed buffered salt solution[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

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The molarity calculator equation

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This equation is commonly abbreviated as: C1V1 = C2V2

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× = ×
C1   V1   C2   V2


Succinyl phosphonateOthersInhibitorinhibitorinhibit

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