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Sucralfate (Synonyms: Sucrose octasulfate–aluminum complex)

Cat. No.: HY-B0644
Handling Instructions

Sucralfate is a cytoprotective agent which has been employed for prevention and treatment of several gastrointestinal diseases.

For research use only. We do not sell to patients.

Sucralfate Chemical Structure

Sucralfate Chemical Structure

CAS No. : 54182-58-0

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 55 In-stock
Estimated Time of Arrival: December 31
100 mg USD 50 In-stock
Estimated Time of Arrival: December 31
500 mg USD 80 In-stock
Estimated Time of Arrival: December 31
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  • Biological Activity

  • Protocol

  • Technical Information

  • Purity & Documentation

  • References

Description

Sucralfate is a cytoprotective agent which has been employed for prevention and treatment of several gastrointestinal diseases.

In Vivo

Sucralfate is a cytoprotective agent which has been employed for prevention and treatment of several gastrointestinal diseases. Enemas containing Sucralfate improves the inflammation and increases the tissue contents of neutral and acid mucins. The content of neutral mucins does not change with the time or concentration of Sucralfate used, while acid mucins increases with concentration and time of intervention. A significant increase in tissue content of neutral mucins in animals subjected to irrigation with Sucralfate (SCF) is found compare to animals irrigated with S.F. 0.9%, regardless of the concentration and duration of intervention[1].

Clinical Trial
Solvent & Solubility
In Vitro: 

H2O : 0.4 mg/mL (0.20 mM; ultrasonic and adjust pH to 2 with HCl)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 0.4887 mL 2.4433 mL 4.8866 mL
5 mM 0.0977 mL 0.4887 mL 0.9773 mL
10 mM 0.0489 mL 0.2443 mL 0.4887 mL
*Please refer to the solubility information to select the appropriate solvent.
References
Animal Administration
[1]

Thirty-six male Wistar rats (300 to 350 g) are used in this study. The animals are divided into two experimental groups with 18 animals in each group. Each experimental group is divided into six subgroups (n=6) according to the intervention solution employed and time of intervention. In the first and second subgroups, 12 animals receive daily rectal enemas containing 40 mL of 0.9% saline solution (control subgroup) at 37°C for two weeks (n=6) and four weeks (n=6). In the second subgroup, 12 animals receive daily rectal enemas containing 40 mL of Sucralfate (SCF) at a concentration of 1.0 g/kg for two weeks (n=6) and four weeks (n=6). Finally, 12 animals of the third subgroup receive daily enemas containing 40 mL of Sucralfate at a concentration of 2.0 g/kg for two weeks (n=6) and four weeks (n=6). In order to standardize the speed and time of application, the enemas are administered in all animals with an infusion pump whose speed is standardized at 2/mL/min[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

References
Molecular Weight

2046.42

Formula

C₁₂H₁₄Al₁₆O₇₅S₈

CAS No.

54182-58-0

SMILES

[O-][Al+3]1([O-][Al+3]([O-])([O-])[O-]1)[O-]S(O[[email protected]]([[email protected]]([[email protected]](OS([O-][Al+3]2([O-][Al+3]([O-])([O-])[O-]2)[O-])(=O)=O)[[email protected]@H](COS([O-][Al+3]3([O-][Al+3]([O-])([O-])[O-]3)[O-])(=O)=O)O4)OS([O-][Al+3]5([O-][Al+3]([O-])([O-])[O-]5)[O-])(=O)=O)[[email protected]@]4([H])O[[email protected]]6([[email protected]](C(OS([O-][Al+3]7([O-][Al+3]([O-])([O-])[O-]7)[O-])(=O)=O)C(COS([O-][Al+3]8([O-][Al+3]([O-])([O-])[O-]8)[O-])(=O)=O)O6)OS([O-][Al+3]9([O-][Al+3]([O-])([O-])[O-]9)[O-])(=O)=O)COS([O-][Al+3]%10([O-][Al+3]([O-])([O-])[O-]%10)[O-])(=O)=O)(=O)=O

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Shipping

Room temperature in continental US; may vary elsewhere

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Sucralfate
Cat. No.:
HY-B0644
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Sucralfate

Cat. No.: HY-B0644