54182-58-0
Chemical Structure
Sucralfate
Synonym(s): Sucrose octasulfate-aluminum complex
- CAS 番号: 54182-58-0
- Formula:C12H14Al16O75S8
- Molecular Weight:2046.42
SMILES: [OSO3[Al2(OH5)]][C@H]([C@@H](C[OSO3[Al2(OH5)]])O1)[C@H](O[S]=O=O=O=[OH5]#[Al]#[Al])[C@]1(C[OSO3[Al2(OH5)]])O[C@@H]2[C@H](O[S]=O=O=O=[OH5]#[Al]#[Al])[C@H](O[S]=O=O=O=[OH5]#[Al]#[Al])[C@H](O[S]=O=O=O=[OH5]#[Al]#[Al])[C@@H](C[OSO3[Al2(OH5)]])O2
Biological Activity: Sucralfate (Sucrose octasulfate-aluminum complex) is a potent and orally active gastroprotectant with no systemic effects. Sucralfate inhibits peptic activity and binds to negatively charged subepithelial proteins exposed during mucosal injury, forming a viscous layer that protects the vascular bed and proliferative zone. Sucralfate is used for prevention and research of several gastrointestinal diseases in vivo[1][2].
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Sucralfate | Sucralfate (Sucrose octasulfate-aluminum complex) is a potent and orally active gastroprotectant with no systemic effects. Sucralfate inhibits peptic activity and binds to negatively charged subepithelial proteins exposed during mucosal injury, forming a viscous layer that protects the vascular bed and proliferative zone. Sucralfate is used for prevention and research of several gastrointestinal diseases in vivo. | |||||||||||||||||||||
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Sucralfate (Standard) | ≥98% | Sucralfate (Standard) is the analytical standard of Sucralfate. This product is intended for research and analytical applications. Sucralfate (Sucrose octasulfate-aluminum complex) is a potent and orally active gastroprotectant with no systemic effects. Sucralfate inhibits peptic activity and binds to negatively charged subepithelial proteins exposed during mucosal injury, forming a viscous layer that protects the vascular bed and proliferative zone. Sucralfate is used for prevention and research of several gastrointestinal diseases in vivo. | ||||||||||||||||||||
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- [1]. Chaim FM, et al. Evaluation of the application of enemas containing sucralfate in tissue content of neutral and acid mucins in experimental model of diversion colitis. Acta Cir Bras. 2014 Sep;29(9):544-52. [Content Brief]
- [2]. Tracy L Hill, et al. Effect of sucralfate on gastric permeability in an ex vivo model of stress-related mucosal disease in dogs. J Vet Intern Med. 2018 Mar;32(2):670-678. [Content Brief]
Keywords
