2. Signaling Pathways
  3. Neuronal Signaling
  4. Cholinesterase (ChE)

Cholinesterase (ChE)

Cholinesterase (ChE)

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Cholinesterase (ChE) is a family of enzymes present in the central nervous system, particularly in nervous tissue, muscle and red cells, which catalyze the hydrolysis of the neurotransmitter acetylcholine into choline and acetic acid, a reaction necessary to allow a cholinergic neuron to return to its resting state after activation. It is one of many important enzymes needed for the proper functioning of the nervous systems of humans.

There are two types: acetylcholinesterase (AChE, acetylcholine hydrolase) and butyrylcholinesterase (BChE, acylcholine acylhydrolase), also known as nonspecific cholinesterase or pseudocholinesterase. AChE is primarily found in the blood on red blood cell membranes, in neuromuscular junctions, and in neural synapses, while BChE is produced in the liver and found primarily in plasma. The difference between the two types of cholinesterase is their relative preferences for substrates: AChE hydrolyzes acetylcholine faster while BChE hydrolyzes butyrylcholine faster.

Cholinesterase (ChE) Isoform Specific Products:

Cholinesterase (ChE) Isoform Comparison
Cat. No. Product Name Effect Purity Chemical Structure
  • HY-B0732R
    Itopride hydrochloride (Standard)
    		Inhibitor
    Itopride (hydrochloride) (Standard) is the analytical standard of Itopride (hydrochloride). This product is intended for research and analytical applications. Itopride (HSR803) hydrochloride is a potent dopamine-2 antagonist and an acetylcholine esterase (AChE) inhibitor. Itopride hydrochloride enhances gastric motility through both antidopaminergic and anti-acetylcholinesterasic actions, can be used as a gastrointestinal prokinetic agent. Itopride can be used for researching gastro-esophageal reflux disease (GERD).
    Itopride hydrochloride (Standard)
  • HY-B0953A
    Pipenzolate bromide
    		Antagonist
    Pipenzolate bromide is a muscarinic receptor antagonist, preventing acetyl choline from binding to the receptors.
    Pipenzolate bromide
  • HY-W049312
    7-Methoxytacrine
    		Inhibitor
    7-Methoxytacrine (7-MEOTA) is an inhibitor of human acetylcholinesterase (hAChE) with an IC50 value of 10 μM, and can be used for the research of Alzheimer's disease (AD).
    7-Methoxytacrine
  • HY-170650
    SMase-IN-1
    		Inhibitor
    SMase-IN-1 (Compound 4) is a bacterial sphingomyelinase enzyme (SMase) inhibitor (IC50 value for B. cereus SMase is 6.43 µM). SMase-IN-1 also inhibits eqBuChE (59.50% inhibition rate at 50 µM concentration). SMase-IN-1 forms a complex with Cu2+ in biometal interactions. SMase-IN-1 reduces B. cereus-induced hemolysis on sheep erythrocytes.
    SMase-IN-1
  • HY-135761S
    Penconazole-d7
    		99.17%
    Penconazole-d7 is the deuterium labeled Penconazole. Penconazole is a typical triazole fungicide, and mainly applied on apples, grapes, and vegetables to control powdery mildew. Penconazole inhibits sterol biosynthesis in fungi. Penconazole decrease AChE activity in the cerebrum and cerebellum of rats.
    Penconazole-d<sub>7</sub>
  • HY-136610R
    Chlorpyrifos-oxon (Standard)
    		Inhibitor
    Chlorpyrifos-oxon (Standard) is the analytical standard of Chlorpyrifos-oxon. This product is intended for research and analytical applications. Chlorpyrifos-oxon, an active metabolite of Chlorpyrifos, is a potent phosphorylating agent that potently inhibits AChE. Chlorpyrifos-oxon can induce cross-linking between subunits of tubulin and disrupt microtubule function.
    Chlorpyrifos-oxon (Standard)
  • HY-N2511R
    Trimyristin (Standard)
    		Inhibitor
    Trimyristin (Standard) is the analytical standard of Trimyristin. This product is intended for research and analytical applications. Trimyristin, an active molluscicidal component of?Myristica fragrans?Houtt, significantly inhibits acetylcholinesterase (AChE), acid and alkaline phosphatase (ACP/ALP) activities in the nervous tissue of?Lymnaea acuminata. IC50s of Trimyristin against AChE, ACP, and ALP are 0.11, 0.16 and 0.18 mM, respectively.
    Trimyristin (Standard)
  • HY-W332450
    Demeton-S
    		Inhibitor
    Demeton-S is an organophosphate insecticide. Demeton-S inhibits butyrylcholinesterase and acetylcholinesterase activity.
    Demeton-S
  • HY-180506
    Tyrosinase-IN-47
    		Inhibitor
    Tyrosinase-IN-47 (compound 6a) is a potent competitive tyrosinase inhibitor with an IC50 of 1.43 µM and a Ki of 0.1142 μM. Tyrosinase-IN-47 also shows inhibition activity in α-Glucosidase (IC50 = 36.26 μM) and acetylcholinesterase (IC50 = 8.26 μM). Tyrosinase-IN-47 exhibits in vitro antioxidant activity, with good scavenging ability for DPPH (IC50 = 4.75 μM) and ABTS (IC50 = 0.04 μM). Tyrosinase-IN-47 displays anti-browning effect on freshly cut potatoes. Tyrosinase-IN-47 can be used for pharmaceutical research.
    Tyrosinase-IN-47
  • HY-W654336
    (S)-Rivastigmine-d4
    		Inhibitor
    (S)-Rivastigmine-d4 is deuterium labeled Rivastigmine. Rivastigmine (ENA 713 free base) is an orally active and potent cholinesterase (ChE) inhibitor and inhibits butyrylcholinesterase (BChE) and acetylcholinesteras (AChE) with IC50s of 0.037 μM , 4.15 μM, respectively. Rivastigmine can pass the blood brain barrier (BBB). Rivastigmine is a parasympathomimetic or cholinergic agent used for the research of mild to moderate dementia of the Alzheimer's type and dementia due to Parkinson's disease.
    (S)-Rivastigmine-d<sub>4</sub>
  • HY-103610R
    4,4'-Dimethoxybenzil (Standard)
    		Inhibitor
    4,4'-Dimethoxybenzil (Standard) is the analytical standard of 4,4'-Dimethoxybenzil (HY-103610). This product is intended for research and analytical applications. 4,4'-Dimethoxybenzil is a human intestinal carboxyl esterase (hiCE) inhibitor with Ki of 70 nM.
    4,4'-Dimethoxybenzil (Standard)
  • HY-W278867R
    trans-3,5-Dimethoxystilbene (Standard)
    		Inhibitor
    trans-3,5-Dimethoxystilbene (Standard) is the analytical standard of trans-3,5-Dimethoxystilbene (HY-W278867). This product is intended for research and analytical applications. trans-3,5-Dimethoxystilbene (trans-Pinosylvin dimethyl ether) is a natural stilbenoid metabolite. trans-3,5-Dimethoxystilbene acts as an acetylcholinesterase inhibitor with a IC50 of 9 μM against Electrophorus electricus acetylcholinesterase. trans-3,5-Dimethoxystilbene binds to acetylcholinesterase and blocks acetylcholine hydrolysis, thereby increasing acetylcholine levels in the cholinergic synaptic cleft. trans-,5-Dimethoxystilbene can be used in the research of neurodegenerative diseases such as Alzheimer's disease.
    trans-3,5-Dimethoxystilbene (Standard)
  • HY-106016
    HP 184
    		Activator
    HP 184 is an acetylcholine release (ChE) stimulator whose ADME properties can be altered by replacing hydrogen with deuterium.
    HP 184
  • HY-N13925
    Arisugacin E
    		Control
    Arisugacin E, a microbial metabolite, is a structural analog of Arisugacin A (HY-N13901). Arisugacin E shows no activity against AChE.
    Arisugacin E
  • HY-124140R
    Heliosupine (Standard)
    		Inhibitor
    Heliosupine (Standard) is the analytical standard of Heliosupine. This product is intended for research and analytical applications. Heliosupine is a pyrrolizidine alkaloid. Heliosupine is an acetylcholinesterase (AChE) inhibitor, with an IC50 0.57 mM. Heliosupine exhibits deterrent effects against generalist herbivores.
    Heliosupine (Standard)
  • HY-180778
    Insecticidal agent 28
    		Inhibitor
    Insecticidal agent 28 (Compound 10) is an insecticide targeting the Culex pipiens. Insecticidal agent 28 exhibits LC₅₀ values for killing larvae and adults of 40.15 ppm and 55.02 ppm respectively. Insecticidal agent 28 inhibits the acetylcholinesterase (AchE) of the Anopheles gambiae. Insecticidal agent 28 shows lower cytotoxicity.
    Insecticidal agent 28
  • HY-127001
    Lycodine
    		Inhibitor
    Lycodine is a lycopodium alkaloid, which can be isolated from Huperzia saururus. Lycodine exhibits anticholinesterase activity.
    Lycodine
  • HY-131922R
    Iso-OMPA (Standard)
    		Inhibitor
    Iso-OMPA (Standard) is the analytical standard of Iso-OMPA. This product is intended for research and analytical applications. Iso-OMPA (Tetraisopropyl pyrophosphoramide) is a selective inhibitor of the irreversible butyrylcholinesterase (BuChE). Iso-OMPA enhances soman toxicity in rats associated with the inhibition of plasma carboxylesterase (CarbE).
    Iso-OMPA (Standard)
  • HY-B0884AR
    Minaprine dihydrochloride (Standard)
    		Inhibitor
    Minaprine dihydrochloride (Standard) is the analytical standard of Minaprine dihydrochloride (HY-B0884A). This product is intended for research and analytical applications. Minaprine dihydrochloride is a brain-penetrant monoamine oxidase inhibitor. Minaprine dihydrochloride also weakly inhibits acetylcholinesterase (AChE) activity. Minaprine dihydrochloride reduces intraneuronal dopamine metabolism, lowers striatal homovanillic acid and dihydroxyphenylacetic acid levels, and raises striatal 3-methoxytyramine and 5-hydroxytryptamine levels. Minaprine dihydrochloride exhibits convulsant, antidepressant properties.
    Minaprine dihydrochloride (Standard)
  • HY-W588214
    Phorate sulfone
    		Inhibitor
    Phorate sulfone, Phorate metabolite, is an insecticide. Phorate sulfone shows inhibitory activity aainst acetylcholinesterase with an IC50 of 40 μM, leading to acetylcholine accumulation at cellular and subcellular levels. Phorate sulfone can be used for the research of severe phorate poisoning.
    Phorate sulfone
Cat. No. Product Name / Synonyms Application Reactivity
Cholinesterase (ChE) Isoform Comparison

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