Cholinesterase (ChE) Inhibitor

Cholinesterase (ChE) Inhibitors (877):

Cat. No.	Nombre del producto	Efecto	Pureza

HY-B1863R

Iprobenfos (Standard)	Inhibitor
Iprobenfos (Standard) is the analytical standard of Iprobenfos (HY-B1863). This product is intended for research and analytical applications. Iprobenfos is an organophosphorus fungicide and is widely used to control the rice blast fungus. Iprobenfos can phosphorylate the -OH group on the serine residue in the active (esteratic) site of ChEs and so inhibit both AChE and BChE activity.

HY-W185336

Dibutyl phenyl phosphate	Inhibitor
Dibutyl phenyl phosphate is a flame retardant. Dibutyl phenyl phosphate is a BChE inhibitor (IC₅₀: 83.6 μM; K_i: 94.5 μM).

HY-76299S2

Galanthamine-d₃ hydrochloride	Inhibitor
Galanthamine-d₃ (Galantamine-d₃) hydrochloride is deuterium-labeled Galanthamine (HY-76299).

HY-B1542

Benactyzine	Inhibitor
Benactyzine is a competitive BChE inhibitor with a K_i of 0.01 mM. Benactyzine is an anticholinergic drug. Benactyzine has the potential for organophosphate poisoning research.

HY-N0740R

Jatrorrhizine chloride (Standard)	Inhibitor
Jatrorrhizine (chloride) (Standard) is the analytical standard of Jatrorrhizine (chloride). This product is intended for research and analytical applications. Jatrorrhizine chloride is an alkaloid isolated from Coptis chinensis with neuroprotective, antimicrobial, antiplasmodial and antioxidant activities. Jatrorrhizine chloride is a potent and orally active inhibitor of AChE (IC50=872 nM) over >115-fold selectivity for BuChE. Jatrorrhizine chloride reduces uptake of serotonin (5-HT) and norepinephrine (NE) via inhibition of uptake-2 transporters.

HY-N14533

Quinolactacin A2	Inhibitor
Quinolactacin A2 inhibits acetylcholinesterase and TNF production.

HY-N13902

Arisugacin B	Inhibitor
Arisugacin B is a potent, orally active and selective acetylcholinesterase (AChE) inhibitor.

HY-17368S1

(Rac)-Rivastigmine-d₆	Inhibitor
(Rac)-Rivastigmine-d₆ is a labelled racemic Rivastigmine. Rivastigmine (ENA 713 free base) is an orally active and potent cholinesterase (ChE) inhibitor and inhibits butyrylcholinesterase (BChE) and acetylcholinesteras (AChE) with IC₅₀s of 0.037 μM , 4.15 μM, respectively. Rivastigmine can pass the blood brain barrier (BBB). Rivastigmine is a parasympathomimetic or cholinergic agent used for the research of mild to moderate dementia of the Alzheimer's type and dementia due to Parkinson's disease.

HY-163662

AE027	Inhibitor
AE027 is a potent inhibitor against both WT and resistant mutation F348Y AChE with the IC₅₀ values of 10 and 43 μM, respectively.

HY-W027553R

Ipidacrine (Standard)	Inhibitor
Ipidacrine (Standard) is the analytical reference standard of Ipidacrine. This product is used for research and analytical applications. Ipidacrine is orally active and blood-brain-barrier-penetrant AChE and BuChE inhibitors with IC₅₀ values of 1 μM and 1.9 μM, respectively, which is also a partial agonist of M2-cholinergic receptors and a reversible cholinesterase inhibitor. Ipidacrine has a stimulating effect on neuromuscular transmission and excitation along the nerve fibres with a moderately anti-pain effect. Ipidacrine is an aminopyridines and is structurally similar to Tacrine (HY-111338). Ipidacrine is effective in various amnesia models, improves erectile function and inhibits K⁺ and Na⁺-channels in the neuronal membrane in diabetic rats. Ipidacrine is promising for research of Alzheimer’s disease, ischaemic stroke, idiopathic neuropathy of the facial nerve, diabetes mellitus-induced erectile dysfunction and other deficits in central or peripheral cholinergic deseases.

HY-105327R

P11149 (Standard)	Inhibitor
P11149 (Standard) is the analytical standard of P11149 (HY-105327). This product is intended for research and analytical applications. P11149 is a competitive, BBB-penetarated weakly, orally active and selective inhibitor of AChE. P11149 exhibits an IC₅₀ of 1.3 μM for rat BChE/AChE. P11149, a Galanthamine derivative, demonstrates central cholinergic activity, behavioral efficacy and safety. P11149 is used in the study for Alzheimer's disease.

HY-N15450

Undulatine	Inhibitor
Undulatine is a potent AChE inhibitor with an IC₅₀ of 7.4 μM. Undulatine is able to cross the BBB by passive permeation and can be used in the study of Alzheimer’s disease.

HY-N3185

N-Methylcalycinine	Inhibitor
N-Methylcalycinine is a nature product with AChE inhibitory activity. N-Methylcalycinine can be isolated from the roots of Stephania epigaea. N-Methylcalycinine can be used for the research of asthma, cancer, dysentery, fever, hyperglycemia, intestinal complaints, inflammation, sleep disturbances, tuberculosis and so on.

HY-107825R

Flavonol (Standard)	Inhibitor
Flavonol (Standard) is the analytical standard of Flavonol. This product is intended for research and analytical applications. Flavonol is a cholinesterase (ChE) inhibitor, with an IC50 value of 120 μM and a Ki value of 74 μM. Flavonol has antioxidant, free radical-scavenging, antibacterial properties, and immune modulation functions. Flavonol inhibits the PriA helicase of Staphylococcus aureus. Flavonol can suppress the production of NO in LPS-activated RAW 264.7 cells by inhibiting the expression of the iNOS enzyme. Flavonol shows protective and analgesic effects in mice through various neuronal pathways. Flavonol can be used in research related to tumors and atherosclerosis diseases.

HY-100919R

Ambenonium chloride (Standard)	Inhibitor
Ambenonium (chloride) (Standard) is the analytical standard of Ambenonium (chloride). This product is intended for research and analytical applications. Ambenonium (WIN 8077) chloride is an orally active and reversible inhibitor of Acetyicholinesterase (AChE) with high affinity. Ambenonium chloride inhibits human AChE with an IC50 value of 0.7 nM (hAChE).

HY-N15323

Samioside	Inhibitor
Samioside is an effective acetylcholinesterase inhibitor that can be isolated from Phlomis nissolii and P. capitata. Samioside possesses free-radical scavenging and antimicrobial activities. Samioside can be used in research on its anti-Alzheimer’s potency.

HY-W020785R

Fosthiazate (Standard)	Inhibitor
Fosthiazate (Standard) is the analytical standard of Fosthiazate. This product is intended for research and analytical applications. Fosthiazate is a broad-spectrum nematicide against various plant parasitic nematodes, including Meloidogyne spp., Globodera spp., and Pratylenchus spp., through inhibiting the synthesis of acetylcholinesterase.

HY-124920

Methiocarb	Inhibitor
Methiocarb (Mercaptodimethur) is an orally active carbamate insecticide. Methiocarb exerts dose-dependent toxic effects on onions. In addition to inhibiting acetylcholinesterase to induce cholinergic excitation, Methiocarb can induce lipid peroxidation in liver, kidney, brain and testicular tissues and alter reduced glutathione levels by generating ROS. Methiocarb can be used for agricultural pest control and research on oxidative stress-related cellular damage in mammals.

HY-N4142R

Cyanidin-3-O-galactoside chloride (Standard)	Inhibitor
Cyanidin-3-O-galactoside (chloride) (Standard) is the analytical standard of Cyanidin-3-O-galactoside (chloride). This product is intended for research and analytical applications. Cyanidin-3-O-galactoside chloride (Ideain chloride) is a component from extract peel of hawthorn fruit (EPHF) with the value of 179.4 mg/g. EPHF exhibits strong AChE inhibitory activity.

HY-N4261R

Dehydronuciferine (Standard)	Inhibitor
Dehydronuciferine is isolated from the leaves of Nelumbo nucifera Gaertn, a acetylcholinesterase (AChE) inhibitor with an IC50 of 25 μg/mL.

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