2. Others Neuronal Signaling Membrane Transporter/Ion Channel
  3. Reference Standards Cholinesterase (ChE) Potassium Channel Sodium Channel
  4. Ipidacrine (Standard)

Ipidacrine (Standard)  (Synonyms: NIK-247 free base (Standard); Amiridine free base (Standard))

Cat. No.: HY-W027553R Purity: 98%
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Ipidacrine (Standard) is the analytical reference standard of Ipidacrine. This product is used for research and analytical applications. Ipidacrine is orally active and blood-brain-barrier-penetrant AChE and BuChE inhibitors with IC50 values of 1 μM and 1.9 μM, respectively, which is also a partial agonist of M2-cholinergic receptors and a reversible cholinesterase inhibitor. Ipidacrine has a stimulating effect on neuromuscular transmission and excitation along the nerve fibres with a moderately anti-pain effect. Ipidacrine is an aminopyridines and is structurally similar to Tacrine (HY-111338). Ipidacrine is effective in various amnesia models, improves erectile function and inhibits K+ and Na+-channels in the neuronal membrane in diabetic rats. Ipidacrine is promising for research of Alzheimer’s disease, ischaemic stroke, idiopathic neuropathy of the facial nerve, diabetes mellitus-induced erectile dysfunction and other deficits in central or peripheral cholinergic deseases.

For research use only. We do not sell to patients.

Ipidacrine (Standard)

Ipidacrine (Standard) Chemical Structure

CAS No. : 62732-44-9

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50 mg Get quote 5 - 6 weeks 4 - 5 weeks 6 - 7 weeks 5 - 6 weeks
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250 mg Get quote 5 - 6 weeks 4 - 5 weeks 6 - 7 weeks 5 - 6 weeks
500 mg Get quote 5 - 6 weeks 4 - 5 weeks 6 - 7 weeks 5 - 6 weeks
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5 g   Get quote  
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Information

Ipidacrine (Standard) is the analytical reference standard of Ipidacrine. This product is used for research and analytical applications. Ipidacrine is orally active and blood-brain-barrier-penetrant AChE and BuChE inhibitors with IC50 values of 1 μM and 1.9 μM, respectively, which is also a partial agonist of M2-cholinergic receptors and a reversible cholinesterase inhibitor. Ipidacrine has a stimulating effect on neuromuscular transmission and excitation along the nerve fibres with a moderately anti-pain effect. Ipidacrine is an aminopyridines and is structurally similar to Tacrine (HY-111338). Ipidacrine is effective in various amnesia models, improves erectile function and inhibits K+ and Na+-channels in the neuronal membrane in diabetic rats. Ipidacrine is promising for research of Alzheimer’s disease, ischaemic stroke, idiopathic neuropathy of the facial nerve, diabetes mellitus-induced erectile dysfunction and other deficits in central or peripheral cholinergic deseases.

Application

The compound is the grade of analytical standard, which is the reference standard supplied assay. It is commonly used in qualitative, quantitative and methodological research experiments in HPLC, GC and MS.
Molecular Weight

188.27

Formula

C12H16N2
CAS No.
SMILES

NC1=C(CCC2)C2=NC3=C1CCCC3
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
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Ipidacrine (Standard) Related Classifications

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Ipidacrine (Standard)62732-44-9NIK-247 free base (Standard) Amiridine free base (Standard)Reference StandardsCholinesterase (ChE)Potassium ChannelSodium ChannelKcsANa channelsNa+ channelsorally activebrain-penetrantAChEBuChEM2-cholinergic receptorsanti-pain effectK+ and Na+-channelsAlzheimer’s diseaseischaemic strokediabetes mellitus-induced erectile dysfunctionother deficits in central or peripheral cholinergic deseasesInhibitorinhibitorinhibit

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