Jatrorrhizine chloride (Standard)
Jatrorrhizine chloride (Standard) is the analytical standard of Jatrorrhizine chloride. This product is intended for research and analytical applications. Jatrorrhizine chloride is an alkaloid isolated from Coptis chinensis with neuroprotective, antimicrobial, antiplasmodial and antioxidant activities. Jatrorrhizine chloride is a potent and orally active inhibitor of AChE (IC50=872 nM) over >115-fold selectivity for BuChE. Jatrorrhizine chloride reduces uptake of serotonin (5-HT) and norepinephrine (NE) via inhibition of uptake-2 transporters.
For research use only. We do not sell to patients.
- Purity: 98%
- CAS No.: 6681-15-8
- Formula: C₂₀H₂₀ClNO₄
- Molecular Weight:373.83
-
Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Product Information
-
Chemical Information
- Purity & Documentation
-
Help & FAQs
Product Information
The compound is the grade of analytical standard, which is the reference standard supplied assay. It is commonly used in qualitative, quantitative and methodological research experiments in HPLC, GC and MS.
Chemical Information
-
CAS No. 6681-15-8
-
Molecular Weight 373.83
-
Formula C₂₀H₂₀ClNO₄
-
SMILES
COC1=C(OC)C2=C[N+]3=C(C4=CC(OC)=C(O)C=C4CC3)C=C2C=C1.[Cl-]
-
Structure Classification
-
Initial Source
-
Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
[1]. Sun S, et al. Jatrorrhizine reduces 5-HT and NE uptake via inhibition of uptake-2 transporters and produces antidepressant-like action in mice. Xenobiotica. 2019 Oct;49(10):1237-1243. [Content Brief]
[3]. C W Wright, et al. In vitro antiplasmodial, antiamoebic, and cytotoxic activities of some monomeric isoquinoline alkaloids. J Nat Prod. 2000 Dec;63(12):1638-40. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Jatrorrhizine chloride (Standard) Related Classifications
HY-N0740R Related Classifications
Powered by Bioz
- Jatrorrhizine chloride (Standard)
- 6681-15-8
- Reference Standards
- Cholinesterase (ChE)
- 5-HT Receptor
- Bacterial
- neuroprotective
- antimicrobial
- antioxidant
- antidepressant
- Alzheimer’s disease
- AD
- antidepressant-like
- depressive disorder
- quaternary isoquinoline
- alkaloid
- antiplasmodial
- antiamoebic
- Cytotoxic
- E. histolytica
- falciparum
- Inhibitor
- inhibitor
- inhibit